KEGG   ENZYME: 3.1.4.41Help
Entry
EC 3.1.4.41                 Enzyme                                 

Name
sphingomyelin phosphodiesterase D;
sphingomyelinase D
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
sphingomyelin ceramide-phosphohydrolase
Reaction(IUBMB)
sphingomyelin + H2O = ceramide phosphate + choline [RN:R02542]
Reaction(KEGG)
Substrate
sphingomyelin [CPD:C00550];
H2O [CPD:C00001]
Product
ceramide phosphate [CPD:C02960];
choline [CPD:C00114]
Comment
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
History
EC 3.1.4.41 created 1978
Pathway
ec00600  Sphingolipid metabolism
Orthology
K01123  sphingomyelin phosphodiesterase D
Genes
AOR: AO090102000335
AFV: AFLA_004420
CIM: CIMG_06182
CPW: CPC735_027310
ABE: ARB_01728
TVE: TRV_03422
Taxonomy
Reference
1  [PMID:622164]
  Authors
Carne HR, Onon EO.
  Title
Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels.
  Journal
Nature 271:246-8 (1978)
Reference
2  [PMID:5543581]
  Authors
Soucek A, Michalec C, Souckova A.
  Title
Identification and characterization of a new enzyme of the group "phospholipase D" isolated from Corynebacterium ovis.
  Journal
Biochim Biophys Acta 227:116-28 (1971)
DOI:10.1016/0005-2744(71)90173-2
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.41
IUBMB Enzyme Nomenclature: 3.1.4.41
ExPASy - ENZYME nomenclature database: 3.1.4.41
BRENDA, the Enzyme Database: 3.1.4.41
CAS: 54992-31-3

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