KEGG   ENZYME: 3.1.4.43Help
Entry
EC 3.1.4.43                 Enzyme                                 

Name
glycerophosphoinositol inositolphosphodiesterase;
1,2-cyclic-inositol-phosphate phosphodiesterase;
D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase;
D-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase;
inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase
Reaction(IUBMB)
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate [RN:R03331]
Reaction(KEGG)
R03331;
(other) R03333
Show
Substrate
1-(sn-glycero-3-phospho)-1D-myo-inositol [CPD:C01225];
H2O [CPD:C00001]
Product
glycerol [CPD:C00116];
1D-myo-inositol 1-phosphate [CPD:C01177]
Comment
This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P
History
EC 3.1.4.43 created 1984, (EC 3.1.4.36 created 1976, incorporated 2002), modified 2002
Orthology
K01124  glycerophosphoinositol inositolphosphodiesterase
Genes
HSA: 54857(GDPD2)
PTR: 465687(GDPD2)
PPS: 100969535(GDPD2)
GGO: 101125597(GDPD2)
PON: 100446576(GDPD2)
NLE: 100582979(GDPD2)
MCC: 695687(GDPD2)
MCF: 102136065(GDPD2)
CSAB: 103232133(GDPD2)
RRO: 104678788(GDPD2)
RBB: 108539315(GDPD2)
CJC: 100412949(GDPD2)
SBQ: 101038113(GDPD2)
MMU: 71584(Gdpd2)
RNO: 302421(Gdpd2)
CGE: 100771225(Gdpd2)
NGI: 103743163(Gdpd2)
HGL: 101706272(Gdpd2)
CCAN: 109680749(Gdpd2)
OCU: 100346403(GDPD2)
TUP: 102484003(GDPD2)
CFA: 480951(GDPD2)
AML: 100477309(GDPD2)
UMR: 103682623(GDPD2)
ORO: 101376595(GDPD2)
FCA: 101088650(GDPD2)
PTG: 102967871(GDPD2)
AJU: 106982398(GDPD2)
BTA: 514673(GDPD2)
BOM: 102272674(GDPD2)
BIU: 109555339(GDPD2)
PHD: 102322450(GDPD2)
CHX: 102173824(GDPD2)
OAS: 101101866(GDPD2)
SSC: 100516309(GDPD2)
CFR: 102513549(GDPD2)
CDK: 105087975(GDPD2)
BACU: 103013177(GDPD2)
LVE: 103091359(GDPD2)
OOR: 101289657(GDPD2)
ECB: 100055691(GDPD2)
EPZ: 103544986(GDPD2) 103546121
EAI: 106827113(GDPD2)
MYB: 102238745(GDPD2)
MYD: 102760571(GDPD2)
HAI: 109385582(GDPD2)
RSS: 109455947(GDPD2)
PALE: 102886565(GDPD2)
LAV: 100665406(GDPD2)
TMU: 101356229
MDO: 100014029(GDPD2)
SHR: 100932224(GDPD2)
GGA: 422217(GDPD2)
MGP: 100544970(GDPD2)
CJO: 107312626(GDPD2)
APLA: 101792816(GDPD2)
ACYG: 106037473(GDPD2)
TGU: 100231010(GDPD2)
GFR: 102031707(GDPD2)
FAB: 101814282(GDPD2)
PHI: 102100679(GDPD2)
PMAJ: 107204083(GDPD2)
CCW: 104691662(GDPD2)
FPG: 101922487(GDPD2)
FCH: 102051523(GDPD2)
CLV: 102095560(GDPD2)
EGZ: 104124264(GDPD2)
AAM: 106496634(GDPD2)
ASN: 102381477(GDPD2)
AMJ: 102574797(GDPD2)
CMY: 102941248(GDPD2)
CPIC: 101950361(GDPD2)
ACS: 100566715(gdpd2)
PVT: 110080167(GDPD2)
PBI: 103063018(GDPD2)
GJA: 107108520(GDPD2)
XLA: 108698333
XTR: 100038173(gdpd2)
NPR: 108800179(GDPD2)
DRE: 563198(gdpd2)
SRX: 107744531(gdpd2) 107752000
SGH: 107550770(gdpd2) 107560350
IPU: 108268889(gdpd2)
AMEX: 103040773(gdpd2)
TRU: 101070529(gdpd2)
LCO: 104923477(gdpd2)
NCC: 104958393(gdpd2)
MZE: 101481713
OLA: 101168550(gdpd2)
XMA: 102230452
PRET: 103471626(gdpd2)
NFU: 107378587(gdpd2)
CSEM: 103390757(gdpd2)
LCF: 108872608(gdpd2)
HCQ: 109516566(gdpd2)
BPEC: 110158919(gdpd2)
ELS: 105029530(gdpd2)
SFM: 108922931(gdpd2)
LCM: 102357097(GDPD2)
 » show all
Taxonomy
Reference
1  [PMID:192216]
  Authors
Dawson RM, Hemington N.
  Title
A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol.
  Journal
Biochem J 162:241-5 (1977)
Reference
2  [PMID:4342209]
  Authors
Dawson RM, Clarke N.
  Title
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.
  Journal
Biochem J 127:113-8 (1972)
Reference
3  [PMID:4353088]
  Authors
Dawson RM, Clarke NG.
  Title
A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney.
  Journal
Biochem J 134:59-67 (1973)
Reference
4  [PMID:1845995]
  Authors
Ross TS, Majerus PW.
  Title
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate.
  Journal
J Biol Chem 266:851-6 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.43
IUBMB Enzyme Nomenclature: 3.1.4.43
ExPASy - ENZYME nomenclature database: 3.1.4.43
BRENDA, the Enzyme Database: 3.1.4.43
CAS: 9076-91-9 72414-13-2

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