KEGG   ENZYME: 3.1.4.45Help
Entry
EC 3.1.4.45                 Enzyme                                 

Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase;
alpha-N-acetylglucosaminyl phosphodiesterase;
lysosomal alpha-N-acetylglucosaminidase;
phosphodiester glycosidase;
alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase;
2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase
Reaction(IUBMB)
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose [RN:R04373]
Reaction(KEGG)
Substrate
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04755];
H2O [CPD:C00001]
Product
N-acetyl-D-glucosamine [CPD:C00140];
glycoprotein phospho-D-mannose [CPD:C04010]
Comment
Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase.
History
EC 3.1.4.45 created 1984
Orthology
K01125  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Genes
HSA: 51172(NAGPA)
PTR: 453894(NAGPA)
PPS: 100989924(NAGPA)
GGO: 101130231(NAGPA)
PON: 100458605(NAGPA)
NLE: 100605673(NAGPA)
MCC: 707352(NAGPA)
MCF: 102127868(NAGPA)
CSAB: 103227805(NAGPA)
RRO: 104654668(NAGPA)
RBB: 108538332(NAGPA)
CJC: 100399724(NAGPA)
SBQ: 101046520(NAGPA)
MMU: 27426(Nagpa)
RNO: 360476(Nagpa)
CGE: 100774024(Nagpa)
NGI: 103744761(Nagpa)
HGL: 101704527(Nagpa)
CCAN: 109684800(Nagpa)
OCU: 100352892(NAGPA)
TUP: 102497727(NAGPA)
CFA: 490019(NAGPA)
AML: 100470535(NAGPA)
UMR: 103668820(NAGPA)
ORO: 101373357(NAGPA)
FCA: 101091582(NAGPA)
PTG: 102971048(NAGPA)
AJU: 106978751(NAGPA)
BTA: 515935(NAGPA)
BOM: 102275466(NAGPA)
BIU: 109578760(NAGPA)
PHD: 102334479(NAGPA)
CHX: 102169152(NAGPA)
OAS: 101104545(NAGPA)
SSC: 100512596(NAGPA)
CFR: 102503696(NAGPA)
CDK: 105098405
BACU: 103007873(NAGPA)
LVE: 103086351(NAGPA)
OOR: 101275254(NAGPA)
ECB: 100069983(NAGPA)
EPZ: 103563128(NAGPA)
EAI: 106825972(NAGPA)
MYB: 102248654(NAGPA)
MYD: 102752240(NAGPA)
HAI: 109392143(NAGPA)
RSS: 109460757(NAGPA)
PALE: 102891536(NAGPA)
LAV: 100659563(NAGPA)
TMU: 101350545
MDO: 100026673(NAGPA)
SHR: 100916276(NAGPA)
OAA: 100089312
GGA: 416395(NAGPA)
MGP: 100548255(NAGPA)
CJO: 107320943(NAGPA)
APLA: 101800969(NAGPA)
ACYG: 106046317(NAGPA)
TGU: 100217812(NAGPA)
GFR: 102038412(NAGPA)
FAB: 101813573(NAGPA)
PHI: 102111151(NAGPA)
PMAJ: 107210961(NAGPA)
CCAE: 111936235(NAGPA)
CCW: 104684926(NAGPA)
FPG: 101919735(NAGPA)
FCH: 102052824(NAGPA)
CLV: 102097700(NAGPA)
EGZ: 104127416(NAGPA)
AAM: 106499990(NAGPA)
ASN: 102386970(NAGPA)
AMJ: 102559983(NAGPA)
PSS: 102457278(NAGPA)
CMY: 102944702(NAGPA)
CPIC: 101944116(NAGPA)
ACS: 100565001(nagpa)
PVT: 110087126(NAGPA)
PBI: 103066432(NAGPA)
GJA: 107114194(NAGPA)
XLA: 108708030
XTR: 100380073(nagpa)
NPR: 108801783(NAGPA)
DRE: 569719(nagpa)
IPU: 108270758(nagpa)
AMEX: 103029606(nagpa)
TRU: 101070394(nagpa)
LCO: 104939057(nagpa)
NCC: 104961681
MZE: 101480679(nagpa)
OLA: 101159945(nagpa)
XMA: 102219487(nagpa)
PRET: 103477595(nagpa)
NFU: 107379282(nagpa)
KMR: 108240306(nagpa)
CSEM: 103388064(nagpa)
SDU: 111234134(nagpa)
HCQ: 109521111(nagpa)
BPEC: 110168494(nagpa)
MALB: 109970085(nagpa)
SASA: 106605373
ELS: 105019241(nagpa)
SFM: 108940728(nagpa)
LCM: 102354196(NAGPA)
CMK: 103175131(nagpa)
CIN: 100184943
SPU: 586707
APLC: 110980138
CRG: 105325388
OBI: 106871408
EPA: 110253013
ADF: 107358275
HMG: 100202760
 » show all
Taxonomy
Reference
1
  Authors
Van den Tweel, W.J.J., Smits, J.P., Ogg, R.L.H.P. and de Bont, J.A.M.
  Title
The involvement of an enantioselective transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida.
  Journal
Appl Microbiol Biotechnol 29:224-230 (1988)
Reference
2  [PMID:4399430]
  Authors
van der Drift C, van Helvoort PE, Vogels GD.
  Title
S-ureidoglycolate dehydrogenase: purification and properties.
  Journal
Arch Biochem Biophys 145:465-9 (1971)
DOI:10.1016/S0003-9861(71)80006-1
Reference
3  [PMID:237557]
  Authors
Van der Drift L, Vogels GD, Van der Drift C.
  Title
Allantoin racemase: a new enzyme from Pseudomonas species.
  Journal
Biochim Biophys Acta 391:240-8 (1975)
DOI:10.1016/0005-2744(75)90170-9
Reference
4  [PMID:6263889]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase.
  Journal
J Biol Chem 256:5717-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.45
IUBMB Enzyme Nomenclature: 3.1.4.45
ExPASy - ENZYME nomenclature database: 3.1.4.45
BRENDA, the Enzyme Database: 3.1.4.45
CAS: 75788-84-0

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