KEGG   ENZYME: 3.1.4.54Help
Entry
EC 3.1.4.54                 Enzyme                                 

Name
N-acetylphosphatidylethanolamine-hydrolysing phospholipase D;
NAPE-PLD;
anandamide-generating phospholipase D;
N-acyl phosphatidylethanolamine phospholipase D;
NAPE-hydrolyzing phospholipase D
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
N-acetylphosphatidylethanolamine phosphatidohydrolase
Reaction(IUBMB)
N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
Substrate
N-acylphosphatidylethanolamine;
H2O [CPD:C00001]
Product
N-acylethanolamine;
1,2-diacylglycerol 3-phosphate
Comment
This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine [1]. No transphosphatidation [1]. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+ [2].
History
EC 3.1.4.54 created 2011
Orthology
K13985  N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D
Genes
HSA: 222236(NAPEPLD)
PTR: 472476(NAPEPLD)
PPS: 100985918(NAPEPLD)
GGO: 101137253(NAPEPLD)
PON: 100172099(NAPEPLD)
NLE: 100597657(NAPEPLD)
MCC: 695318(NAPEPLD)
MCF: 101866055(NAPEPLD)
CSAB: 103226680(NAPEPLD)
RRO: 104673548(NAPEPLD)
RBB: 108515835(NAPEPLD) 108516781
CJC: 100398969(NAPEPLD)
SBQ: 101035720(NAPEPLD)
MMU: 242864(Napepld)
RNO: 296757(Napepld)
CGE: 100759349(Napepld)
NGI: 103732204(Napepld)
HGL: 101720071 101722949(Napepld)
CCAN: 109683824(Napepld)
OCU: 100352578(NAPEPLD)
TUP: 102497728(NAPEPLD)
CFA: 100685330(NAPEPLD)
AML: 100480963(NAPEPLD)
UMR: 103658645(NAPEPLD)
ORO: 101382909(NAPEPLD)
FCA: 101090597(NAPEPLD)
PTG: 102971600(NAPEPLD)
AJU: 106972731(NAPEPLD)
BTA: 541291(NAPEPLD)
BOM: 102267222(NAPEPLD)
BIU: 109557357(NAPEPLD)
PHD: 102320957(NAPEPLD)
CHX: 102189544(NAPEPLD)
OAS: 101119039(NAPEPLD)
SSC: 100737731(NAPEPLD)
CFR: 102512680(NAPEPLD)
CDK: 105093013(NAPEPLD)
BACU: 103008372(NAPEPLD)
LVE: 103084546(NAPEPLD)
OOR: 101288700(NAPEPLD)
ECB: 100050247(NAPEPLD)
EPZ: 103541734(NAPEPLD)
EAI: 106837113(NAPEPLD)
MYB: 102251197(NAPEPLD)
MYD: 102751565(NAPEPLD)
HAI: 109389513(NAPEPLD)
RSS: 109454150(NAPEPLD)
PALE: 102890709(NAPEPLD)
LAV: 100654395(NAPEPLD)
TMU: 101361415
MDO: 100017822(NAPEPLD)
SHR: 100922754(NAPEPLD)
OAA: 100076416(NAPEPLD)
GGA: 417719(NAPEPLD)
MGP: 100544476(NAPEPLD)
CJO: 107323995(NAPEPLD)
APLA: 101804191(NAPEPLD)
ACYG: 106035555(NAPEPLD)
TGU: 100232210(NAPEPLD)
GFR: 102032062(NAPEPLD)
FAB: 101814848(NAPEPLD)
PHI: 102109609(NAPEPLD)
PMAJ: 107204704(NAPEPLD)
CCW: 104686879(NAPEPLD)
FPG: 101919393(NAPEPLD)
FCH: 102047018(NAPEPLD)
CLV: 102087617(NAPEPLD)
EGZ: 104128561(NAPEPLD)
AAM: 106485772(NAPEPLD)
ASN: 102388069(NAPEPLD)
AMJ: 102564505(NAPEPLD)
PSS: 102451163(NAPEPLD)
CMY: 102934785(NAPEPLD)
CPIC: 101938499(NAPEPLD)
ACS: 100559466(napepld)
PVT: 110077181(NAPEPLD)
PBI: 103056311(NAPEPLD)
GJA: 107113713(NAPEPLD)
XLA: 100036998(napepld.L) 100137693(napepld.S)
XTR: 100494898(napepld)
NPR: 108790209(NAPEPLD)
DRE: 568061(napepld)
SANH: 107694176
SGH: 107576752 107590591(napepld)
AMEX: 103040918(napepld)
TRU: 101065463(napepld)
LCO: 104940541(napepld)
NCC: 104962590(napepld)
MZE: 101469541(napepld)
OLA: 101162968(napepld)
XMA: 102223768(napepld)
NFU: 107385164(napepld)
CSEM: 103382793(napepld)
LCF: 108894945(napepld)
HCQ: 109520041(napepld)
BPEC: 110156007(napepld)
ELS: 105023099(napepld)
LCM: 102353963(NAPEPLD)
CMK: 103176983(napepld)
SPU: 577498
APLC: 110974316
TUT: 107363395
CEL: CELE_Y37E11AR.3(nape-2) CELE_Y37E11AR.4(nape-1)
CBR: CBG08290
OBI: 106876738
HMG: 100205873
VCN: VOLCADRAFT_106116(mot42)
MNG: MNEG_0591
APRO: F751_5638
SCE: YPL103C(FMP30)
ERC: Ecym_7074
KMX: KLMA_10803(FMP30)
NCS: NCAS_0C01900(NCAS0C01900)
NDI: NDAI_0E02620(NDAI0E02620)
TPF: TPHA_0A01240(TPHA0A01240)
TBL: TBLA_0B04420(TBLA0B04420)
TDL: TDEL_0A05260(TDEL0A05260)
KAF: KAFR_0E00700(KAFR0E00700)
CAL: CAALFM_C100470CA(CaO19.6061)
CAUR: QG37_02159
SLB: AWJ20_2454(FMP30)
PTE: PTT_03276
CNE: CNC04610
CNB: CNBC2560
DFA: DFA_03394
SMIN: v1.2.018948.t2(symbB.v1.2.018948.t2)
GNI: GNIT_0043
TEE: Tel_09040
ADI: B5T_02787
BBAC: EP01_10405
CABY: Cabys_805
 » show all
Taxonomy
Reference
1  [PMID:14634025]
  Authors
Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N
  Title
Molecular characterization of a phospholipase D generating anandamide and its congeners.
  Journal
J Biol Chem 279:5298-305 (2004)
DOI:10.1074/jbc.M306642200
  Sequence
[hsa:222236] [mmu:242864] [rno:296757]
Reference
2  [PMID:16527816]
  Authors
Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N
  Title
Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family.
  Journal
J Biol Chem 281:12325-35 (2006)
DOI:10.1074/jbc.M512359200
  Sequence
[rno:296757] [mmu:242864] [hsa:222236]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.54
IUBMB Enzyme Nomenclature: 3.1.4.54
ExPASy - ENZYME nomenclature database: 3.1.4.54
BRENDA, the Enzyme Database: 3.1.4.54

DBGET integrated database retrieval system