KEGG   ENZYME: 3.1.6.12Help
Entry
EC 3.1.6.12                 Enzyme                                 

Name
N-acetylgalactosamine-4-sulfatase;
chondroitinsulfatase;
chondroitinase;
arylsulfatase B;
acetylgalactosamine 4-sulfatase;
N-acetylgalactosamine 4-sulfate sulfohydrolase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823]
Reaction(KEGG)
R07823(G)
Show
Comment
Acts also on N-acetylglucosamine 4-sulfate.
History
EC 3.1.6.12 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01135  arylsulfatase B
Genes
HSA: 411(ARSB)
PTR: 737316(ARSB)
PPS: 100987929(ARSB)
GGO: 101138081(ARSB)
PON: 100457196(ARSB)
NLE: 100587589(ARSB)
MCC: 709136(ARSB)
MCF: 102116401(ARSB)
CSAB: 103223561(ARSB)
RRO: 104662974(ARSB)
RBB: 108528898(ARSB)
CJC: 100394090(ARSB)
SBQ: 101045515(ARSB)
MMU: 11881(Arsb)
RNO: 25227(Arsb)
CGE: 100759794(Arsb)
NGI: 103750289(Arsb)
HGL: 101719731(Arsb)
CCAN: 109675232 109675293(Arsb)
OCU: 103346484(ARSB) 103346606
TUP: 102469500(ARSB)
CFA: 610364(ARSB)
AML: 100467836(ARSB)
UMR: 103681492(ARSB)
ORO: 101374250(ARSB)
FCA: 100216331(ARSB)
PTG: 102963642(ARSB)
AJU: 106974796(ARSB)
BTA: 538401(ARSB)
BOM: 102279001(ARSB)
BIU: 109564662(ARSB)
PHD: 102335024(ARSB)
CHX: 102189402(ARSB)
OAS: 101108314(ARSB)
SSC: 102158016(ARSB)
CFR: 102507706(ARSB)
CDK: 105084869(ARSB)
BACU: 103001911(ARSB)
LVE: 103080763(ARSB)
OOR: 101281243(ARSB)
ECB: 100073268(ARSB)
EPZ: 103548666(ARSB)
EAI: 106841176(ARSB)
MYB: 102252145(ARSB)
MYD: 102758054(ARSB)
HAI: 109381893(ARSB)
RSS: 109445645(ARSB)
PALE: 102887255(ARSB)
LAV: 100665589(ARSB)
TMU: 101359357
MDO: 100032622(ARSB)
SHR: 100931900(ARSB)
OAA: 100088121(ARSB)
GGA: 771459(ARSB)
MGP: 104914958(ARSB)
CJO: 107305934(ARSB)
APLA: 101802978(ARSB)
ACYG: 106042122(ARSB)
TGU: 100228383(ARSB)
GFR: 102044758(ARSB)
FAB: 101813661(ARSB)
PHI: 102102961(ARSB)
PMAJ: 107216097(ARSB)
CCW: 104695689(ARSB)
FPG: 101910790(ARSB)
FCH: 102049359(ARSB)
CLV: 102091560(ARSB)
EGZ: 104124897(ARSB)
AAM: 106487821
ASN: 102377963(ARSB)
AMJ: 106737251(ARSB)
PSS: 102445150(ARSB)
CMY: 102947173(ARSB)
CPIC: 101938081(ARSB)
ACS: 100564703(arsb)
PVT: 110073968 110084605(ARSB)
PBI: 103060554(ARSB)
GJA: 107117399(ARSB)
XLA: 108717994(arsb.L)
XTR: 100493013(arsb)
NPR: 108799973(ARSB)
DRE: 100538007(arsb)
SRX: 107724712(arsb)
SANH: 107694537(arsb)
SGH: 107574102(arsb)
CCAR: 109046309
IPU: 108279373(arsb)
AMEX: 103041418(arsb)
TRU: 101061832(arsb)
LCO: 104926623(arsb)
NCC: 104966860(arsb)
MZE: 101485324(arsb)
OLA: 101169377(arsb)
XMA: 102227522(arsb)
PRET: 103473308(arsb)
NFU: 107374848(arsb)
LCF: 108895444(arsb)
HCQ: 109517689(arsb)
BPEC: 110157319(arsb)
SASA: 100380367(arsb)
ELS: 105015172(arsb)
SFM: 108925070(arsb)
LCM: 102353782(ARSB)
CMK: 103177857(arsb)
CIN: 100187202
DME: Dmel_CG7402(CG7402) Dmel_CG8646(CG8646)
LHU: 105669509
NVL: 108561322
BMOR: 101737480
API: 100575414
SMIN: v1.2.004770.t3(symbB.v1.2.004770.t3) v1.2.006990.t1(symbB.v1.2.006990.t1) v1.2.006992.t1(symbB.v1.2.006992.t1) v1.2.025906.t1(symbB.v1.2.025906.t1) v1.2.025906.t2(symbB.v1.2.025906.t2) v1.2.033030.t1(symbB.v1.2.033030.t1) v1.2.034521.t1(symbB.v1.2.034521.t1)
FCY: FRACYDRAFT_182357(ARSB1)
NGD: NGA_0431201(ARSB) NGA_0431202(ARSB)
BOS: BSY19_414(arsb)
RBA: RB1475(arsB) RB198 RB348 RB5417
VBL: L21SP4_00136(atsA_1)
 » show all
Taxonomy
Reference
1  [PMID:976430]
  Authors
Farooqui AA.
  Title
The desulphation of hexosamine sulphates by arylsulphatase B.
  Journal
Experientia 32:1242-4 (1976)
Reference
2  [PMID:738706]
  Authors
Gorham SD, Cantz M.
  Title
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide.
  Journal
Hoppe Seylers Z Physiol Chem 359:1811-4 (1978)
Reference
3  [PMID:7370276]
  Authors
Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S.
  Title
The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase.
  Journal
Biochim Biophys Acta 612:373-83 (1980)
DOI:10.1016/0005-2744(80)90120-5
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.12
IUBMB Enzyme Nomenclature: 3.1.6.12
ExPASy - ENZYME nomenclature database: 3.1.6.12
BRENDA, the Enzyme Database: 3.1.6.12
CAS: 55354-43-3

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