KEGG   ENZYME: 3.1.6.13Help
Entry
EC 3.1.6.13                 Enzyme                                 

Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
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History
EC 3.1.6.13 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01136  iduronate 2-sulfatase
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS) 100982799
GGO: 101148217(IDS) 101149182
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102123797 102137236(IDS)
CSAB: 103232717(IDS) 103232718
RRO: 104657812(IDS) 104657813
RBB: 108539780(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
MMU: 15931(Ids)
RNO: 363513(Ids)
CGE: 100763345(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CCAN: 109695031(Ids)
OCU: 100356659(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
ORO: 101382674(IDS)
FCA: 101081450(IDS) 111559194
PTG: 102968319(IDS)
AJU: 106988547(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
PHD: 102342734(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CDK: 105104103(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
HAI: 109388991(IDS)
RSS: 109435087(IDS)
PALE: 102893087(IDS)
LAV: 100668951(IDS)
TMU: 101348522
MDO: 100025173(IDS)
SHR: 100932918(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
TGU: 100231299(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
AAM: 106487578(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
PBI: 103053966(IDS)
GJA: 107107996(IDS)
XLA: 108698425
XTR: 100135738(ids)
NPR: 108783898(IDS)
DRE: 559959(ids)
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
IPU: 108268807(ids)
AMEX: 103032782(ids)
TRU: 101066362(ids)
LCO: 104932265(ids)
NCC: 104948380(ids)
MZE: 101484170(ids)
OLA: 101158287(ids)
XMA: 102223507(ids)
PRET: 103471071(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
CSEM: 103391272(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025
ELS: 105027395(ids)
SFM: 108922862(ids)
LCM: 102348043(IDS)
CMK: 103178266(ids)
CIN: 100185385
DME: Dmel_CG12014(Ids)
DSI: Dsimw501_GD13763(Dsim_GD13763)
MDE: 101896463
AAG: 5572289
AME: 724550
BIM: 100747349
BTER: 100647993
SOC: 105193763
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
HST: 105185301
DQU: 106749424
CFO: 105253432
LHU: 105673528
PGC: 109860994
PCF: 106787197
NVI: 100119376
MDL: 103570322
TCA: 655669
DPA: 109540804
NVL: 108560267
BMOR: 101744799
PMAC: 106715653
PRAP: 111001403
HAW: 110370991
CLEC: 106670417
ZNE: 110832438
MYI: 110456562
OBI: 106871045
EPA: 110243498
ADF: 107340223
NGD: NGA_0701900(IDS)
 » show all
Taxonomy
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim Biophys Acta 708:134-40 (1982)
DOI:10.1016/0167-4838(82)90213-8
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc Natl Acad Sci U S A 70:2134-8 (1973)
DOI:10.1073/pnas.70.7.2134
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim Biophys Acta 661:106-11 (1981)
DOI:10.1016/0005-2744(81)90088-7
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J Biochem (Tokyo) 91:433-41 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.13
IUBMB Enzyme Nomenclature: 3.1.6.13
ExPASy - ENZYME nomenclature database: 3.1.6.13
BRENDA, the Enzyme Database: 3.1.6.13
CAS: 50936-59-9

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