KEGG   ENZYME: 3.1.7.11Help
Entry
EC 3.1.7.11                 Enzyme                                 

Name
geranyl diphosphate diphosphatase;
geraniol synthase;
geranyl pyrophosphate pyrophosphatase;
GES;
CtGES
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geraniol + diphosphate [RN:R08396]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geraniol [CPD:C01500];
diphosphate [CPD:C00013]
Comment
Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase.
History
EC 3.1.7.11 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K20979  geranyl diphosphate diphosphatase
Reference
1  [PMID:14657409]
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant Physiol 134:370-9 (2004)
DOI:10.1104/pp.103.032946
  Sequence
Reference
2  [PMID:15680985]
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry 66:285-93 (2005)
DOI:10.1016/j.phytochem.2004.12.004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.11
IUBMB Enzyme Nomenclature: 3.1.7.11
ExPASy - ENZYME nomenclature database: 3.1.7.11
BRENDA, the Enzyme Database: 3.1.7.11

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