KEGG   ENZYME: 3.1.7.8Help
Entry
EC 3.1.7.8                  Enzyme                                 

Name
tuberculosinol synthase;
Rv3378c
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming)
Reaction(IUBMB)
tuberculosinyl diphosphate + H2O = tuberculosinol + diphosphate [RN:R09828]
Reaction(KEGG)
Substrate
tuberculosinyl diphosphate [CPD:C19836];
H2O [CPD:C00001]
Product
tuberculosinol [CPD:C19963];
diphosphate [CPD:C00013]
Comment
Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9, isotuberculosinol synthase.
History
EC 3.1.7.8 created 2011
Orthology
K15911  tuberculosinol/isotuberculosinol synthase
Genes
AGE: AA314_01782
MTU: Rv3378c
MTV: RVBD_3378c
MTC: MT3488
MRA: MRA_3418
MTF: TBFG_13414
MTB: TBMG_03429
MTK: TBSG_03452
MTZ: TBXG_003406
MTG: MRGA327_20850
MTUR: CFBS_3580
MTD: UDA_3378c
MTUC: J113_23650
MTUE: J114_18115
MTUH: I917_23750
MTUL: TBHG_03316
MTUT: HKBT1_3567
MTUU: HKBT2_3574
MBB: BCG_3449c
MBT: JTY_3449
MAF: MAF_33930
MMIC: RN08_3726
 » show all
Taxonomy
Reference
1  [PMID:21228491]
  Authors
Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T
  Title
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
  Journal
Biosci Biotechnol Biochem 75:75-81 (2011)
DOI:10.1271/bbb.100570
  Sequence
[mtu:Rv3378c]
Reference
2  [PMID:21290071]
  Authors
Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T.
  Title
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and  the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
  Journal
Org Biomol Chem (2011)
DOI:10.1039/c0ob00884b
  Sequence
[mtu:Rv3378c]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.8
IUBMB Enzyme Nomenclature: 3.1.7.8
ExPASy - ENZYME nomenclature database: 3.1.7.8
BRENDA, the Enzyme Database: 3.1.7.8

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