KEGG   ENZYME: 3.1.8.2Help
Entry
EC 3.1.8.2                  Enzyme                                 

Name
diisopropyl-fluorophosphatase;
DFPase;
tabunase;
somanase;
organophosphorus acid anhydrolase;
organophosphate acid anhydrase;
OPA anhydrase;
diisopropylphosphofluoridase;
dialkylfluorophosphatase;
diisopropyl phosphorofluoridate hydrolase;
isopropylphosphorofluoridase;
diisopropylfluorophosphonate dehalogenase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
BRITE hierarchy
Sysname
diisopropyl-fluorophosphate fluorohydrolase
Reaction(IUBMB)
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride [RN:R01533]
Reaction(KEGG)
Substrate
diisopropyl fluorophosphate [CPD:C00202];
H2O [CPD:C00001]
Product
diisopropyl phosphate [CPD:C03113];
fluoride [CPD:C00742]
Comment
Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.
History
EC 3.1.8.2 created 1961 as EC 3.8.2.1, transferred 1992 to EC 3.1.8.2
Reference
1
  Authors
Augustinsson, K.-B. and Heimburger, G.
  Title
Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun).
  Journal
Acta Chem Scand 8:753-761 (1954)
Reference
2
  Authors
Augustinsson, K.-B. and Heimburger, G.
  Title
Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase.
  Journal
Acta Chem Scand 8:762-767 (1954)
Reference
3
  Authors
Augustinsson, K.-B. and Heimburger, G.
  Title
Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies.
  Journal
Acta Chem Scand 8:1533-1541 (1954)
Reference
4  [PMID:13479457]
  Authors
COHEN JA, WARRINGA MG.
  Title
Purification and properties of dialkylfluorophosphatase.
  Journal
Biochim Biophys Acta 26:29-39 (1957)
DOI:10.1016/0006-3002(57)90050-1
Reference
5
  Authors
Mounter, L.A.
  Title
Enzymic hydrolysis of organophosphorus compounds.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 541-550.
Reference
6
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.8.2
IUBMB Enzyme Nomenclature: 3.1.8.2
ExPASy - ENZYME nomenclature database: 3.1.8.2
BRENDA, the Enzyme Database: 3.1.8.2
CAS: 9032-18-2

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