KEGG   ENZYME: 3.13.1.3Help
Entry
EC 3.13.1.3                 Enzyme                                 

Name
2'-hydroxybiphenyl-2-sulfinate desulfinase;
gene dszB-encoded hydrolase;
2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase;
DszB;
HBPSi desulfinase;
2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase;
HPBS desulfinase;
2-(2-hydroxyphenyl)benzenesulfinate hydrolase;
2-(2'-hydroxyphenyl)benzenesulfinate desulfinase;
2-(2-hydroxyphenyl)benzenesulfinate desulfinase
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
2'-hydroxybiphenyl-2-sulfinate sulfohydrolase
Reaction(IUBMB)
2'-hydroxybiphenyl-2-sulfinate + H2O = 2-hydroxybiphenyl + sulfite [RN:R07311]
Reaction(KEGG)
Substrate
2'-hydroxybiphenyl-2-sulfinate [CPD:C06742];
H2O [CPD:C00001]
Product
2-hydroxybiphenyl [CPD:C02499];
sulfite [CPD:C00094]
Comment
The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the plasmid-encoded dibenzothiophene-desulfurization (dsz) operon. The enzyme has a narrow substrate specificity with biphenyl-2-sulfinate being the only other substrate known to date [2].
History
EC 3.13.1.3 created 2000 as EC 3.1.2.24, transferred 2005 to EC 3.13.1.3
Orthology
K05977  2'-hydroxybiphenyl-2-sulfinate desulfinase
Genes
MAV: MAV_3808
MAVD: NF84_17355
MAVR: LA63_17530
MAVA: LA64_17520
MYO: OEM_10430 OEM_p100030
MGO: AFA91_16300
MABL: MMASJCM_2558
GTA: BCM27_00645
Taxonomy
Reference
1  [PMID:9308179]
  Authors
Oldfield C, Pogrebinsky O, Simmonds J, Olson ES, Kulpa CF.
  Title
Elucidation of the metabolic pathway for dibenzothiophene desulphurization by Rhodococcus sp. strain IGTS8 (ATCC 53968).
  Journal
Microbiology 143 ( Pt 9):2961-73 (1997)
DOI:10.1099/00221287-143-9-2961
Reference
2  [PMID:12147352]
  Authors
Nakayama N, Matsubara T, Ohshiro T, Moroto Y, Kawata Y, Koizumi K, Hirakawa Y, Suzuki M, Maruhashi K, Izumi Y, Kurane R.
  Title
A novel enzyme, 2'-hydroxybiphenyl-2-sulfinate desulfinase (DszB), from a dibenzothiophene-desulfurizing bacterium Rhodococcus erythropolis KA2-5-1: gene overexpression and enzyme characterization.
  Journal
Biochim Biophys Acta 1598:122-30 (2002)
DOI:10.1016/S0167-4838(02)00365-5
Reference
3  [PMID:12801508]
  Authors
Watkins LM, Rodriguez R, Schneider D, Broderick R, Cruz M, Chambers R, Ruckman E, Cody M, Mrachko GT.
  Title
Purification and characterization of the aromatic desulfinase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase.
  Journal
Arch Biochem Biophys 415:14-23 (2003)
DOI:10.1016/S0003-9861(03)00230-3
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.3
IUBMB Enzyme Nomenclature: 3.13.1.3
ExPASy - ENZYME nomenclature database: 3.13.1.3
UM-BBD (Biocatalysis/Biodegradation Database): 3.13.1.3
BRENDA, the Enzyme Database: 3.13.1.3
CAS: 198154-06-2

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