KEGG   ENZYME: 3.13.1.5Help
Entry
EC 3.13.1.5                 Enzyme                                 

Name
carbon disulfide hydrolase;
CS2 hydrolase (misleading);
carbon disulfide lyase;
CS2-converting enzyme;
carbon disulphide-lyase (decarboxylating)
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
carbon-disulfide hydrogen-sulfide-lyase (decarboxylating)
Reaction(IUBMB)
carbon disulfide + 2 H2O = CO2 + 2 hydrogen sulfide (overall reaction) [RN:R10538];
(1a) carbon disulfide + H2O = carbonyl sulfide + hydrogen sulfide [RN:R10534];
(1b) carbonyl sulfide + H2O = CO2 + hydrogen sulfide [RN:R10535]
Reaction(KEGG)
Substrate
carbon disulfide [CPD:C19033];
H2O [CPD:C00001];
carbonyl sulfide [CPD:C07331]
Product
CO2 [CPD:C00011];
hydrogen sulfide [CPD:C00283];
carbonyl sulfide [CPD:C07331]
Comment
The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate.
History
EC 3.13.1.5 created 2013 as EC 4.4.1.27, transferred 2017 to EC 3.13.1.5
Orthology
K20499  carbon disulfide hydrolase
Genes
SSO: SSO1214
SIS: LS215_0963
SIH: SiH_0575
Taxonomy
Reference
1  [PMID:22012399]
  Authors
Smeulders MJ, Barends TR, Pol A, Scherer A, Zandvoort MH, Udvarhelyi A, Khadem AF, Menzel A, Hermans J, Shoeman RL, Wessels HJ, van den Heuvel LP, Russ L, Schlichting I, Jetten MS, Op den Camp HJ
  Title
Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon.
  Journal
Nature 478:412-6 (2011)
DOI:10.1038/nature10464
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.5
IUBMB Enzyme Nomenclature: 3.13.1.5
ExPASy - ENZYME nomenclature database: 3.13.1.5
BRENDA, the Enzyme Database: 3.13.1.5

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