KEGG   ENZYME: 3.2.1.10Help
Entry
EC 3.2.1.10                 Enzyme                                 

Name
oligo-1,6-glucosidase;
limit dextrinase (erroneous);
isomaltase;
sucrase-isomaltase;
exo-oligo-1,6-glucosidase;
dextrin 6alpha-glucanohydrolase;
alpha-limit dextrinase;
dextrin 6-glucanohydrolase;
oligosaccharide alpha-1,6-glucohydrolase;
alpha-methylglucosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
oligosaccharide 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by EC 3.2.1.1 (alpha-amylase), and in isomaltose
Reaction(KEGG)
Comment
This enzyme, like EC 3.2.1.33 (amylo-alpha-1,6-glucosidase), can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose alpha-glucosidase). Differs from EC 3.2.1.33 (amylo-alpha-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.
History
EC 3.2.1.10 created 1961, modified 2000, modified 2013
Pathway
ec00052  Galactose metabolism
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K01182  oligo-1,6-glucosidase
K01203  sucrase-isomaltase
Genes
HSA: 6476(SI)
PTR: 470988(SI)
PPS: 100973298(SI)
GGO: 101135022(SI)
PON: 100454405(SI)
NLE: 100585192(SI)
MCC: 700840(SI)
MCF: 102128108(SI)
CSAB: 103221316(SI)
RRO: 104658581(SI)
RBB: 108540915(SI)
CJC: 100410281(SI)
SBQ: 101041197(SI)
MMU: 69983(Sis)
RNO: 497756(Si)
CGE: 100773620(Si)
NGI: 103731721(Si)
HGL: 101711933(Si)
CCAN: 109679495 109679496(Si)
OCU: 100009093(SI)
TUP: 102498900(SI)
CFA: 488141(SI)
AML: 100464408(SI)
UMR: 103664425(SI)
ORO: 101381119(SI)
FCA: 100144605(SI)
PTG: 102964729(SI)
AJU: 106987454(SI)
BTA: 504366(SI)
BOM: 102268612(SI)
BIU: 109564411(SI)
PHD: 102329276(SI)
CHX: 102187897(SI)
OAS: 101102774(SI)
SSC: 100623884(SI)
CFR: 102523832(SI)
CDK: 105085981(SI)
BACU: 103011824(SI)
LVE: 103080987(SI)
OOR: 101284967(SI)
ECB: 100063242(SI)
EPZ: 103566440(SI)
EAI: 106842405(SI)
MYB: 102254382(SI)
MYD: 102754902(SI)
HAI: 109373269
RSS: 109438332(SI)
PALE: 102885979(SI)
LAV: 100666668(SI)
TMU: 101355803
MDO: 100013945(SI)
SHR: 100932100(SI)
OAA: 100681776(MGAM)
TSP: Tsp_01057
MYI: 110459523
LAK: 106164793
SCE: YBR299W(MAL32) YGR287C(IMA1) YGR292W(MAL12) YIL172C(IMA3) YJL216C(IMA5) YJL221C(IMA4) YOL157C(IMA2)
TDL: TDEL_0A00110(TDEL0A00110) TDEL_0B07670(TDEL0B07670) TDEL_0D06530(TDEL0D06530)
PIC: PICST_29292(MAL9) PICST_60352(MAL7) PICST_78743(MAL8)
CAL: CAALFM_C504940WA(CaO19.3982) CAALFM_CR10790WA(MAL2)
CAUR: QG37_04198
NCR: NCU06523(gh13-4)
NTE: NEUTE1DRAFT129372(NEUTE1DRAFT_129372) NEUTE1DRAFT38613(NEUTE1DRAFT_38613)
MGR: MGG_07547
CMT: CCM_08695
ANI: AN3516.2
PNO: SNOG_03925(SNOG_03924) SNOG_07977 SNOG_08825
EHI: EHI_130690(337.t00007)
ESA: ESA_02710
CSK: ES15_2781
CTU: CTU_12510(malL)
KPE: KPK_A0108(palI)
SRL: SOD_c21340(malL)
RAA: Q7S_13350
ECA: ECA1850(palI)
PATR: EV46_08855
PATO: GZ59_27540(palI)
ETA: ETA_16540(palI)
EPY: EpC_17230(palI)
EPR: EPYR_01851(malL)
EAM: EAMY_1858(malL)
EAY: EAM_1823(palI)
ERJ: EJP617_29700(palI)
VVU: VV2_0256
VVY: VVA0760
VSP: VS_II0163
VAN: VAA_02896
VTA: B1500(dexB)
PPR: PBPRB0410(DEXA)
MYA: MORIYA_1775(malL)
TAU: Tola_1233
LIM: L103DPR2_00080(malL_2)
LCH: Lcho_3323
AZA: AZKH_2679
RET: RHE_CH03282(malL)
REL: REMIM1_CH03343(malL)
REP: IE4803_PD00181(malL)
RHN: AMJ98_CH03479(malL)
RHT: NT26_3769(malL)
RHX: AMK02_CH03368(malL)
REZ: AMJ99_CH03528(malL)
CAK: Caul_0303
KRO: BVG79_00469(malL)
CID: P73_4360
GOH: B932_0827
BSU: BSU02840(ycdG) BSU34560(malL)
BSH: BSU6051_02840(ycdG) BSU6051_34560(malL)
BSUT: BSUB_00333(ycdG) BSUB_03685(malL)
BSUL: BSUA_00333(ycdG) BSUA_03685(malL)
BSS: BSUW23_01455(ycdG)
BSQ: B657_02840(ycdG) B657_34560(mdxL)
BSX: C663_0275(ycdG) C663_3342(malL)
BLI: BL00491(malL)
BLD: BLi00664(malL)
BLH: BaLi_c07530(malL)
BAY: RBAM_003100(ycdG)
BAQ: BACAU_0251(malL1)
BYA: BANAU_0252(ycdG) BANAU_3362(malL)
BAMP: B938_01300
BAML: BAM5036_0269(ycdG)
BAMA: RBAU_0282(ycdG)
BAMN: BASU_0267(ycdG)
BAMB: BAPNAU_0251(malL1) BAPNAU_3368(malL5)
BAMT: AJ82_01705
BAMY: V529_02730(ycdG)
BMP: NG74_00290(ycdG) NG74_03347(malL_2)
BAO: BAMF_0255(ycdG)
BAZ: BAMTA208_01295(ycdG)
BQL: LL3_00266(ycdG)
BXH: BAXH7_00269(ycdG)
BQY: MUS_0267(ycdG) MUS_3794(malL1)
BAMI: KSO_018110
BAMC: U471_02690
BAMF: U722_01600
BHA: BH2903
BAN: BA_4231(malL)
BAR: GBAA_4231(malL)
BAT: BAS3924
BAH: BAMEG_4272(malL)
BAI: BAA_4254(malL)
BANT: A16_42330
BANR: A16R_42880
BANS: BAPAT_4058
BANV: DJ46_2924(malL)
BCE: BC4015
BCA: BCE_4066(malL)
BCZ: BCE33L3772(malL)
BCR: BCAH187_A4140(malL)
BCB: BCB4264_A4121(malL)
BCU: BCAH820_4034(malL)
BCG: BCG9842_B1118(malL)
BCQ: BCQ_3804(malL)
BCX: BCA_4125(malL)
BNC: BCN_3920
BCF: bcf_19965
BCER: BCK_15140
BTK: BT9727_3756(malL)
BTL: BALH_3635(malL)
BTB: BMB171_C3680(malL)
BTT: HD73_4300
BTHI: BTK_21175
BTC: CT43_CH4022(malL)
BTM: MC28_3305(malL)
BTG: BTB_c41490(malL)
BTI: BTG_29345
BTW: BF38_5186(malL)
BWW: bwei_0937(malL)
BMYO: BG05_2009(malL)
BMYC: DJ92_1108(malL)
BMQ: BMQ_1439(malL)
BMD: BMD_1797
BCOA: BF29_2004(malL) BF29_2011(malL)
BACP: SB24_08255
BACL: BS34A_03390(ycdG) BS34A_37650(malL)
BGY: BGLY_0693(malL)
BKW: BkAM31D_03265(malL_2)
BBEV: BBEV_1151(malL)
AFL: Aflv_2271(malL)
ANM: GFC28_1977(malL) GFC28_2758(malL)
AAMY: GFC30_1665(malL) GFC30_299(malL)
ANL: GFC29_2676(malL) GFC29_3457(malL)
HHD: HBHAL_2478(malL1) HBHAL_4171(malL2)
VPN: A21D_01957(malL_1)
SHA: SH0072(malL)
LMO: lmo0184
LMOC: LMOSLCC5850_0178(malL-1)
LMOE: BN418_0193
LMOB: BN419_0197
LMOD: LMON_0182
LMOW: AX10_09375
LMOQ: LM6179_0474(treA) LM6179_0560(malL)
LMR: LMR479A_0193(treA) LMR479A_0273(malL)
LMF: LMOf2365_0195(malL-1) LMOf2365_0270(malL-2)
LMOG: BN389_01970(malL) BN389_02730(malL_2)
LMOL: LMOL312_0182(malL-1) LMOL312_0255(malL-2)
LMQ: LMM7_0205(treC) LMM7_0287
LML: lmo4a_0200(malL-1) lmo4a_0280(malL-2)
LMW: LMOSLCC2755_0183(malL-1) LMOSLCC2755_0255(malL-2)
LMX: LMOSLCC2372_0185(malL-1)
LMZ: LMOSLCC2482_0184(malL-1) LMOSLCC2482_0257(malL-2)
LMON: LMOSLCC2376_0155(malL-1)
LMOS: LMOSLCC7179_0178(malL-1)
LMOY: LMOSLCC2479_0184(malL-1)
LMOT: LMOSLCC2540_0187(malL-1) LMOSLCC2540_0263(malL-2)
LMOA: LMOATCC19117_0193(malL-1) LMOATCC19117_0265(malL-2)
LIN: lin0223
LWE: lwe0225(malL)
LSG: lse_0161(malL)
EAN: Eab7_1592(malL) Eab7_2380
PPY: PPE_00435
PPM: PPSC2_02385(malL)
PPO: PPM_0433(malL)
PPOL: X809_01975
PPQ: PPSQR21_004400(amyA)
PPOY: RE92_09545
PMS: KNP414_02140(malL) KNP414_05337(malL3) KNP414_07386(malL4)
PRI: PRIO_1328(malL1) PRIO_2155(malL3) PRIO_5530(malL5)
LPK: LACPI_1484(malL)
STB: SGPB_0717(malL)
SCF: Spaf_0439
LPL: lp_3627
LPJ: JDM1_0178(agl2) JDM1_0181(agl3) JDM1_2897(agl6)
LPS: LPST_C0155(agl2) LPST_C0157(agl3) LPST_C1936(treC)
LJO: LJ_0743
LJF: FI9785_582(malL)
LSL: LSL_1712
LSI: HN6_01431
LCA: LSEI_0406
LCB: LCABL_04780(malL) LCABL_28460(agl2)
LCW: BN194_04830(malL) BN194_27950(agl)
LGA: LGAS_0518
LRE: Lreu_0083
LRT: LRI_0091
LFE: LAF_0739
LFR: LC40_0498
LFF: LBFF_0754
LRH: LGG_02696(treC)
LRG: LRHM_2589
LRL: LC705_00489(treC) LC705_02679(treC)
LRA: LRHK_2786(malL) LRHK_436(malL) LRHK_504(malL)
LBH: Lbuc_0108
LBN: LBUCD034_0148(treE)
LSN: LSA_01770(malL)
PPE: PEPE_0521
PCE: PECL_405(malL)
OOE: OEOE_0040
LCI: LCK_00664
LGS: LEGAS_1054(alg2) LEGAS_1146(alg4) LEGAS_1148(agl1) LEGAS_1806(alg3)
CBZ: Cbs_1444
CBEI: LF65_03194
CSR: Cspa_c17490(malL1)
CPAT: CLPA_c03550(malL1) CLPA_c18070(malL5) CLPA_c31850(malL2) CLPA_c31920(malL4)
CPAE: CPAST_c03550(malL1) CPAST_c18070(malL2) CPAST_c31850(malL4) CPAST_c31920(malL5)
FPR: FP2_08740
BFI: CIY_31210
CCT: CC1_17010
CPY: Cphy_2342
BPRL: CL2_19440
HSD: SD1D_0676(malL)
ERT: EUR_19480
ERA: ERE_22040
CTHM: CFE_0365
TIT: Thit_0423
CSC: Csac_2428
ATE: Athe_0165
TOC: Toce_1741
TTM: Tthe_1923
MPU: MYPU_1030(MYPU_1030) MYPU_6330(MYPU_6330)
MGF: MGF_3555
MCAC: MCCP01_0222(mdxL)
MCAP: MCCPF38_00222(dexB)
MCAR: MCCPILRI181_00218(dexB)
MCAI: MCCG_0218
MLC: MSB_A0232
MSY: MS53_0108
AOC: Aocu_07280(malL)
MBJ: KQ51_00382(malL_1) KQ51_01464(malL_2)
SFI: SFUL_185
SGU: SGLAU_31820(malL)
AUW: AURUGA1_01491(malL_3)
ART: Arth_0913
CFL: Cfla_1154
CFI: Celf_2714
SERJ: SGUI_2532
PPC: HMPREF9154_0315(malL)
ACIJ: JS278_00358(malL_2)
MPH: MLP_19390(malL) MLP_49990(malL)
MGG: MPLG2_3483(malL)
NDA: Ndas_2932
NAL: B005_5471(malL)
NML: Namu_4926
GOB: Gobs_4886
BSD: BLASA_4747(malL)
MMAR: MODMU_5501(malL)
AMI: Amir_3009
SESP: BN6_23950(malL3)
ASE: ACPL_6822(malL)
ACTN: L083_6403(treS)
AFS: AFR_33005
ACTS: ACWT_6692
TPYO: X956_02380
BLO: BL1526(agl)
BLJ: BLD_1497
BLN: Blon_2453
BLON: BLIJ_2526
BLL: BLJ_1989
BLM: BLLJ_1871
BAD: BAD_1571(agl)
BADL: BADO_1677
BLA: BLA_1517(agl)
BBB: BIF_01597
BBC: BLC1_1535
BLV: BalV_1535
BLW: W7Y_1587
BLS: W91_1622
BANI: Bl12_1482
BANL: BLAC_07905
BANM: EN10_08045
BDE: BDP_2221
BDN: BBDE_2088
BBRU: Bbr_0559(agl2) Bbr_1855(agl1)
BBRS: BS27_0548(agl2) BS27_1848(agl1)
BAST: BAST_0122
BTP: D805_1797
BCOR: BCOR_0130
BKS: BBKW_1777
BPSP: AH67_08505
BANG: BBAG_0023
BSCA: BBSC_2517
GVG: HMPREF0421_20204(malL)
DGO: DGo_CA0574(malL)
RBA: RB2986
TDE: TDE0107
LIL: LA_1466(amyA)
ABAS: ACPOL_5097
PDI: BDI_0930
CPI: Cpin_2575
MGOT: MgSA37_01990(malL)
SLI: Slin_3625
HSW: Hsw_1715
FBR: FBFL15_2612(malL)
DOK: MED134_06429(malL)
DDO: I597_2272(malL)
ZGA: ZOBELLIA_530(malL)
POM: MED152_05090(malL)
WIN: WPG_1904
HHI: HAH_0971(aglA1)
HME: HFX_1044(amy3)
 » show all
Taxonomy
Reference
1  [PMID:291933]
  Authors
Hauri HP, Quaroni A, Isselbacher KJ.
  Title
Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase.
  Journal
Proc Natl Acad Sci U S A 76:5183-6 (1979)
DOI:10.1073/pnas.76.10.5183
Reference
2  [PMID:7002920]
  Authors
Sjostrom H, Noren O, Christiansen L, Wacker H, Semenza G.
  Title
A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein.
  Journal
J Biol Chem 255:11332-8 (1980)
Reference
3  [PMID:6479163]
  Authors
Rodriguez IR, Taravel FR, Whelan WJ.
  Title
Characterization and function of pig intestinal sucrase-isomaltase and its separate subunits.
  Journal
Eur J Biochem 143:575-82 (1984)
DOI:10.1111/j.1432-1033.1984.tb08408.x
Reference
4  [PMID:6060462]
  Authors
Khan NA, Eaton NR
  Title
Purification and characterization of maltase and alpha-methyl glucosidase from yeast.
  Journal
Biochim Biophys Acta 146:173-80 (1967)
DOI:10.1016/0005-2744(67)90084-8
Reference
5  [PMID:15291818]
  Authors
Yamamoto K, Nakayama A, Yamamoto Y, Tabata S
  Title
Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae.
  Journal
Eur J Biochem 271:3414-20 (2004)
DOI:10.1111/j.1432-1033.2004.04276.x
  Sequence
[sce:YGR287C]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.10
IUBMB Enzyme Nomenclature: 3.2.1.10
ExPASy - ENZYME nomenclature database: 3.2.1.10
BRENDA, the Enzyme Database: 3.2.1.10
CAS: 9032-15-9

DBGET integrated database retrieval system