KEGG   ENZYME: 3.2.1.106Help
Entry
EC 3.2.1.106                Enzyme                                 

Name
mannosyl-oligosaccharide glucosidase;
Glc3Man9NAc2 oligosaccharide glucosidase;
trimming glucosidase I;
CWH41 (gene name);
MOGS (gene name);
mannosyl-oligosaccharide glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting)
Reaction(IUBMB)
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose [RN:R05979]
Reaction(KEGG)
R05979(G)
Show
Substrate
Glc3Man9GlcNAc2-[protein];
H2O [CPD:C00001]
Product
Glc2Man9GlcNAc2-[protein];
beta-D-glucopyranose [CPD:C00221]
Comment
This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.
History
EC 3.2.1.106 created 1984, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01228  mannosyl-oligosaccharide glucosidase
Genes
HSA: 7841(MOGS)
PTR: 740472(MOGS)
PPS: 100989540(MOGS)
GGO: 101148967(MOGS)
PON: 100456318(MOGS)
NLE: 100587064(MOGS)
MCC: 708913(MOGS)
MCF: 102131903(MOGS)
CSAB: 103220027(MOGS)
RRO: 104674816(MOGS)
RBB: 108531677(MOGS)
CJC: 100399857(MOGS)
SBQ: 101050054(MOGS)
MMU: 57377(Mogs)
RNO: 103692171 78947(Gcs1)
CGE: 100689098(Mogs)
NGI: 103726994(Mogs)
HGL: 101699668(Mogs)
CCAN: 109692434(Mogs)
OCU: 100349132(MOGS)
TUP: 102469724(MOGS)
CFA: 483104(MOGS)
AML: 100473274(MOGS)
UMR: 103671412(MOGS)
ORO: 101380088(MOGS)
FCA: 101086221(MOGS)
PTG: 102965884(MOGS)
AJU: 106988593(MOGS)
BTA: 516155(MOGS)
BOM: 102271661(MOGS)
BIU: 109565909
PHD: 102337257(MOGS)
CHX: 102171985(MOGS)
OAS: 101118003(MOGS)
SSC: 100513204(MOGS)
CFR: 102503430(MOGS)
CDK: 105105961(MOGS)
BACU: 102999832(MOGS)
LVE: 103084054(MOGS)
OOR: 101274685(MOGS)
ECB: 100069105(MOGS)
EPZ: 103557690(MOGS)
EAI: 106823842(MOGS)
MYB: 102262392(MOGS)
MYD: 102775421(MOGS)
HAI: 109371217(MOGS)
RSS: 109441724 109457419(MOGS)
PALE: 102887551(MOGS)
LAV: 100657938(MOGS)
TMU: 101345839
MDO: 100017334(MOGS)
SHR: 100925812(MOGS)
GGA: 107049491(MOGS)
MGP: 104916406(MOGS)
CJO: 107306839(MOGS)
FAB: 101811361(MOGS)
PHI: 102101442(MOGS)
PMAJ: 107203112(MOGS)
FPG: 101910764(MOGS)
FCH: 102051577(MOGS)
AAM: 106487298(MOGS)
ASN: 112548011(MOGS)
AMJ: 102576397(MOGS)
CMY: 102941231(MOGS)
CPIC: 101939841(MOGS)
ACS: 100558509(mogs)
PVT: 110079822(MOGS)
PBI: 103067986(MOGS)
GJA: 107114281(MOGS)
XLA: 100158418(mogs.L)
XTR: 619362(mogs)
NPR: 108796278 108803080(MOGS)
DRE: 567913(mogs)
IPU: 108260492 108260493(Mogs)
AMEX: 103032841(mogs)
TRU: 101061971(mogs)
LCO: 104926976(mogs)
NCC: 104951177(mogs)
MZE: 101475138(mogs)
OLA: 101164458(mogs)
XMA: 102226259(mogs)
PRET: 103466387(mogs)
NFU: 107375288(mogs)
KMR: 108231066(mogs)
CSEM: 103383539(mogs)
LCF: 108896565(mogs)
SDU: 111236637(mogs)
HCQ: 109511469(mogs)
BPEC: 110165316(mogs)
MALB: 109961400(mogs)
OTW: 112231722(mogs)
ELS: 105029335(mogs)
SFM: 108924334(mogs)
LCM: 102359377(MOGS)
CMK: 103172295(mogs)
CIN: 100183132
SPU: 591837(mogs)
APLC: 110981262
SKO: 100372636
DME: Dmel_CG1597(GCS1)
DPE: 6602679
DSI: Dsimw501_GD15993(Dsim_GD15993)
DWI: 6648708
MDE: 101894492
AAG: 5576381
AME: 411730
BIM: 100745926
BTER: 100642977
SOC: 105201295
AEC: 105151670
ACEP: 105621167
PBAR: 105428250
HST: 105189509
DQU: 106745826
CFO: 105249065
PGC: 109853555
PCF: 106788557
NVI: 100119845
MDL: 103570799
TCA: 661492
DPA: 109543454
NVL: 108567459
BMOR: 101742535
HAW: 110380113
API: 100159015
DNX: 107161371
CLEC: 106670041
ZNE: 110837085
TUT: 107359578
CEL: CELE_F13H10.4(mogs-1)
CBR: CBG05981
BMY: Bm1_40265
CRG: 105331294
MYI: 110460508
OBI: 106869785
LAK: 106158814
EGL: EGR_08968
EPA: 110250425
ADF: 107327751
HMG: 100204917
ATH: AT1G24320 AT1G67490(GCS1)
THJ: 104807884
CIT: 102626422
TCC: 18609047
GRA: 105785861
EGR: 104433660
LJA: Lj4g3v2539160.1(Lj4g3v2539160.1) Lj4g3v2949800.1(Lj4g3v2949800.1)
ADU: 107482112
AIP: 107632002
FVE: 101304833
CSV: 101210818
CMO: 103488898
MCHA: 111019700
CMAX: 111492274
CMOS: 111458598
CPEP: 111801444
RCU: 8286815
JCU: 105636116
POP: 7477030
JRE: 109003148
VVI: 100264375
SLY: 101267114
SPEN: 107020771
SOT: 102580572
NSY: 104228399
INI: 109172062
SIND: 105168395
HAN: 110926203
LSV: 111881539
CCAV: 112527654
BVG: 104897586
SOE: 110794228
NNU: 104591694
OSA: 4327748
DOSA: Os01t0921200-01(Os01g0921200)
OBR: 102711038
BDI: 100822845
ATS: 109778661(LOC109778661)
SBI: 8059369
ZMA: 103652327
SITA: 101767079
PDA: 103706515
EGU: 105051156
MUS: 103987628
DCT: 110097965
PEQ: 110032801
AOF: 109823842
ATR: 18438178
PPP: 112289032
MNG: MNEG_6941
APRO: F751_4830
SCE: YGL027C(CWH41)
ERC: Ecym_1427
KMX: KLMA_20048(CWH41)
NCS: NCAS_0A01760(NCAS0A01760)
NDI: NDAI_0D03690(NDAI0D03690)
TPF: TPHA_0K01720(TPHA0K01720)
TBL: TBLA_0A08950(TBLA0A08950)
TDL: TDEL_0F02570(TDEL0F02570)
KAF: KAFR_0F03510(KAFR0F03510)
PIC: PICST_39865(CWH41)
SPAA: SPAPADRAFT_146978(CWH41)
CAL: CAALFM_C406100WA(CWH41)
CDU: CD36_45640(CWH41)
CAUR: QG37_01892
SLB: AWJ20_2073(CWH41)
NCR: NCU03657(gh63-1)
NTE: NEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SSCK: SPSK_05967
MAW: MAC_03939
MAJ: MAA_01473
CMT: CCM_07809
MBE: MBM_05686
ANI: AN6606.2
ANG: ANI_1_240134(An15g01420)
CIM: CIMG_13554(CIMG10187)
ABE: ARB_07582
TVE: TRV_07006
ABP: AGABI1DRAFT53637(AGABI1DRAFT_53637)
ABV: AGABI2DRAFT217075(AGABI2DRAFT_217075)
MGL: MGL_1071
DFA: DFA_05938
SMIN: v1.2.029725.t1(symbB.v1.2.029725.t1)
NGD: NGA_2124800(GCS1)
 » show all
Taxonomy
Reference
1  [PMID:7358674]
  Authors
Elting JJ, Chen WW, Lennarz WJ.
  Title
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
  Journal
J Biol Chem 255:2325-31 (1980)
Reference
2  [PMID:479161]
  Authors
Grinna LS, Robbins PW.
  Title
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
  Journal
J Biol Chem 254:8814-8 (1979)
Reference
3  [PMID:7014569]
  Authors
Kilker RD Jr, Saunier B, Tkacz JS, Herscovics A.
  Title
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
  Journal
J Biol Chem 256:5299-603 (1981)
Reference
4  [PMID:7358666]
  Authors
Grinna LS, Robbins PW.
  Title
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
  Journal
J Biol Chem 255:2255-8 (1980)
Reference
5  [PMID:7356331]
  Authors
Michael JM, Kornfeld S.
  Title
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
  Journal
Arch Biochem Biophys 199:249-58 (1980)
DOI:10.1016/0003-9861(80)90278-7
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.106
IUBMB Enzyme Nomenclature: 3.2.1.106
ExPASy - ENZYME nomenclature database: 3.2.1.106
BRENDA, the Enzyme Database: 3.2.1.106
CAS: 78413-07-7

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