KEGG   ENZYME: 3.2.1.113Help
Entry
EC 3.2.1.113                Enzyme                                 

Name
mannosyl-oligosaccharide 1,2-alpha-mannosidase;
mannosidase 1A;
mannosidase 1B;
1,2-alpha-mannosidase;
exo-alpha-1,2-mannanase;
mannose-9 processing alpha-mannosidase;
glycoprotein processing mannosidase I;
mannosidase I;
Man9-mannosidase;
ManI;
1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase
Reaction(IUBMB)
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2
Reaction(KEGG)
(other) R05982(G) R06722(G)
Show
Comment
Involved in the synthesis of glycoproteins.
History
EC 3.2.1.113 created 1986
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01230  mannosyl-oligosaccharide alpha-1,2-mannosidase
Genes
HSA: 10905(MAN1A2) 11253(MAN1B1) 4121(MAN1A1) 57134(MAN1C1)
PTR: 457159(MAN1A2) 463148(MAN1A1) 473099(MAN1B1) 736491(MAN1C1)
PPS: 100977047(MAN1A2) 100983605(MAN1A1) 100984948(MAN1C1) 100987343(MAN1B1)
GGO: 101133209(MAN1A2) 101134859(MAN1B1) 101142550(MAN1C1) 101144345(MAN1A1)
PON: 100432279(MAN1B1) 100434522(MAN1A1) 100439526(MAN1C1) 100459953(MAN1A2)
NLE: 100579310(MAN1A1) 100592662(MAN1A2) 100594141(MAN1C1) 100594686(MAN1B1)
MCC: 706918(MAN1B1) 711548(MAN1A2) 714609(MAN1A1) 719686(MAN1C1)
MCF: 101867098(MAN1B1) 102116178(MAN1A2) 102133475(MAN1C1) 102134558(MAN1A1)
CSAB: 103224125(MAN1A2) 103225352(MAN1C1) 103239582(MAN1B1) 103240478(MAN1A1)
RRO: 104656091(MAN1C1) 104669636(MAN1B1) 104670284(MAN1A1) 104670672(MAN1A2)
RBB: 108518016(MAN1C1) 108528145(MAN1A2) 108529738(MAN1A1) 108542887(MAN1B1)
CJC: 100387951(MAN1A1) 100392624(MAN1B1) 100396923(MAN1A2) 100411429(MAN1C1)
SBQ: 101029383(MAN1C1) 101032054(MAN1B1) 101039212(MAN1A1) 101047170(MAN1A2)
MMU: 17155(Man1a) 17156(Man1a2) 227619(Man1b1) 230815(Man1c1)
RNO: 294410(Man1a1) 295319(Man1a2) 362625(Man1c1) 499751(Man1b1)
CGE: 100756512 100761494(Man1c1) 100767553(Man1a1) 100770527(Man1a2) 103158974
NGI: 103725065(Man1c1) 103732606 103734033(Man1a2) 103736289(Man1a1) 103741172(Man1b1)
HGL: 101699709(Man1c1) 101700934(Man1a2) 101714110(Man1a1) 101724891(Man1b1)
CCAN: 109683046(Man1c1) 109683051 109685361 109685366 109693393(Man1a1) 109697987(Man1b1)
OCU: 100009182(MAN1A1) 100338665(MAN1A2) 100354369(MAN1C1)
TUP: 102470543(MAN1B1) 102475708(MAN1A1) 102490275(MAN1A2) 102498287(MAN1C1)
CFA: 476275(MAN1A1) 478178(MAN1C1) 480667 483141(MAN1A2)
AML: 100467154(MAN1A1) 100478118(MAN1B1) 100478751(MAN1A2) 100480907(MAN1C1)
UMR: 103663450(MAN1A1) 103666782(MAN1C1) 103675308(MAN1B1) 103680866(MAN1A2)
FCA: 101086830(MAN1A2) 101099737(MAN1C1) 101100723(MAN1A1) 105261146 111557571
PTG: 102948947(MAN1B1) 102953645(MAN1A2) 102953958(MAN1A1) 102956478(MAN1C1)
AJU: 106968317(MAN1A1) 106977625(MAN1C1) 106978925(MAN1A2) 106989099(MAN1B1)
BTA: 107131137(MAN1B1) 530027(MAN1A1) 532645(MAN1A2) 615012(MAN1C1)
BOM: 102266017(MAN1A2) 102269574(MAN1A1) 102277240 102277814 102286189(MAN1C1)
PHD: 102321857(MAN1A1) 102323160(MAN1B1) 102323859 102338104(MAN1A2) 102344405(MAN1C1)
CHX: 102172355(MAN1A1) 102178963(MAN1A2) 102182048(MAN1B1) 102182552(MAN1C1) 106501835
OAS: 101102298 101103326(MAN1A1) 101108177(MAN1A2) 101118089(MAN1C1) 105605821(MAN1B1)
SSC: 100154147(MAN1A2) 100524150(MAN1C1) 100627465(MAN1B1) 396919(MAN1A1)
CFR: 102503605(MAN1A1) 102510529(MAN1A2) 102513732 102517452 102523440(MAN1C1)
CDK: 105088351(MAN1A1) 105089605(MAN1A2) 105100665(MAN1C1) 105106185(MAN1B1) 105106205 105106772
BACU: 103003282 103005884(MAN1A1) 103007272(MAN1C1) 103008754(MAN1B1) 103018894(MAN1A2)
LVE: 103070296(MAN1C1) 103086557(MAN1B1) 103087206(MAN1A2) 103087551(MAN1A1)
OOR: 101275150(MAN1B1) 101277960(MAN1A1) 101282517(MAN1A2) 101283566(MAN1C1)
ECB: 100057488(MAN1C1) 100066466(MAN1A2) 100072869(MAN1A1) 100147103(MAN1B1) 100147680
EPZ: 103555530(MAN1A1) 103556781(MAN1C1) 103559230 103560293(MAN1A2) 103568009(MAN1B1)
EAI: 106830488(MAN1A1) 106835703(MAN1A2) 106839943(MAN1C1) 106845522(MAN1B1)
MYB: 102238828(MAN1A2) 102240083(MAN1B1) 102246069(MAN1A1) 102247391(MAN1C1)
MYD: 102763868(MAN1C1) 102764904(MAN1A1) 102766164(MAN1A2) 102775495(MAN1B1)
RSS: 109435594(MAN1C1) 109440720 109446829(MAN1A2) 109452195(MAN1A1) 109460895(MAN1B1)
PALE: 102887313(MAN1A1) 102889844(MAN1A2) 102890593(MAN1B1) 102897246(MAN1C1)
LAV: 100657059(MAN1A2) 100658532(MAN1A1) 100664627(MAN1B1) 100670902 100671581(MAN1C1)
MDO: 100010854(MAN1A2) 100022731(MAN1B1) 100023598(MAN1A1) 100617488(MAN1C1)
OAA: 100079674(MAN1A1) 100080650(MAN1B1) 100081124(MAN1A2)
GGA: 417296(MAN1B1) 418265(MAN1A2) 419588(MAN1C1) 421726(MAN1A1)
MGP: 100543997(MAN1B1) 100546016(MAN1A2) 100549489(MAN1C1) 100549765(MAN1A1)
CJO: 107311841(MAN1A1) 107319054(MAN1A2) 107321628(MAN1B1) 107323893(MAN1C1)
APLA: 101789687(MAN1C1) 101795067(MAN1A1) 101803362(MAN1B1) 101803658(MAN1A2)
ACYG: 106032458(MAN1A1) 106037118(MAN1B1) 106038021(MAN1C1) 106049769(MAN1A2)
TGU: 100220181(MAN1A2) 100221810(MAN1C1) 100223461(MAN1B1) 100232070(MAN1A1)
GFR: 102031555(MAN1B1) 102038714(MAN1A1) 102039589(MAN1A2) 102039998(MAN1C1)
FAB: 101814086(MAN1A1) 101816081(MAN1B1) 101817258(MAN1A2) 101820958(MAN1C1)
PHI: 102101333(MAN1A2) 102103624(MAN1B1) 102108536(MAN1C1) 102109517(MAN1A1)
PMAJ: 107201780(MAN1A1) 107208361(MAN1A2) 107212037(MAN1B1) 107214221(MAN1C1)
CCAE: 111927193(MAN1A1) 111936881(MAN1B1) 111938572(MAN1A2) 111939097(MAN1C1)
CCW: 104687107(MAN1A2) 104688195(MAN1B1) 104691020(MAN1A1) 104694641(MAN1C1)
FPG: 101910863(MAN1A1) 101914433(MAN1B1) 101918152(MAN1C1) 101918831 101922245
FCH: 102045806(MAN1B1) 102048637(MAN1C1) 102052529(MAN1A2) 102054649(MAN1A1)
CLV: 102083787(MAN1B1) 102087646(MAN1A2) 102093752(MAN1A1) 102094812(MAN1C1)
EGZ: 104124017(MAN1B1) 104126519(MAN1A2) 104131968(MAN1A1) 104134894(MAN1C1)
AAM: 106485019(MAN1C1) 106494264(MAN1B1) 106497207(MAN1A2) 106498000(MAN1A1)
ASN: 102369572(MAN1A1) 102378356(MAN1C1) 102387590(MAN1B1) 102388362(MAN1A2)
AMJ: 102558211(MAN1C1) 102563847(MAN1A1) 102567138(MAN1B1) 106736681(MAN1A2)
PSS: 102449928(MAN1A1) 102451974(MAN1C1) 102453471(MAN1A2) 102455673(MAN1B1)
CMY: 102930970(MAN1C1) 102934433 102942408(MAN1B1) 102944110(MAN1A1) 102946268
CPIC: 101932451(MAN1C1) 101947106(MAN1B1) 101948035(MAN1A2) 101950812(MAN1A1)
ACS: 100552898(man1a1) 100553205(man1c1) 100561704(man1a2) 100562395(man1b1)
PVT: 110076944(MAN1A2) 110078803(MAN1B1) 110083601(MAN1A1) 110084141(MAN1C1)
PBI: 103051064(MAN1C1) 103052908(MAN1B1) 103057418(MAN1A1) 103063461(MAN1A2)
GJA: 107108705(MAN1A1) 107110812(MAN1C1) 107114859(MAN1A2) 107123282(MAN1B1)
XLA: 108708264 108716798 108717911 431910(man1c1.S) 446337(man1a2.L) 447291(man1b1.L) 734993
XTR: 100145194(man1b1) 100216029(man1a2) 100485889(man1c1) 100491314(man1a1)
NPR: 108788290(MAN1C1) 108792840(MAN1A1) 108797130(MAN1B1) 108797861(MAN1A2)
DRE: 101882461 335538(man1a2) 556237(man1b1b) 562592(man1b1a) 566078(man1a1)
IPU: 108255760(man1b1) 108256527(man1c1) 108257868(man1a1) 108266693(man1a2) 108279088
AMEX: 103022471(man1b1) 103024141 103028203 103030688(man1a2) 103042818(man1a1)
LCO: 104921495(man1a2) 104923806(man1b1) 104924713(man1c1) 104930877 104933631(man1a1) 109137102
MZE: 101464129 101465263(man1a1) 101475381(man1b1) 101483462(man1a2)
OLA: 101155716(man1c1) 101156826(man1b1) 101158740 101162719(man1a2) 101168136
KMR: 108240356 108241416 108244885(man1a1) 108245625(man1b1) 108247704(man1a2)
SDU: 111218623(man1a2) 111221245 111226918(man1b1) 111235719 111237597(man1a1)
HCQ: 109510052(man1a2) 109515390 109515442 109523542(man1a1) 109527092(man1b1)
BPEC: 110154656(man1b1) 110156066(man1a2) 110164288 110166909(man1a1) 110174250
LCM: 102347754(MAN1B1) 102354592(MAN1C1) 102364126(MAN1A1) 102365619 102366726(MAN1A2)
CMK: 103179580 103180170(man1a2) 103180403(man1b1) 103182593(man1a1)
DME: Dmel_CG11874(alpha-Man-Ib) Dmel_CG31202(alpha-Man-Ic) Dmel_CG42275(alpha-Man-Ia)
DSI: Dsimw501_GD17544(Dsim_GD17544) Dsimw501_GD17996(Dsim_GD17996) Dsimw501_GD24646(Dsim_GD24646)
AME: 413579
NVI: 100119267 100119928(Alpha-man-i)
CEL: CELE_C52E4.5(mans-2) CELE_D2030.1(mans-1) CELE_T03G11.4(mans-3) CELE_ZC410.3(mans-4)
BMY: Bm1_35990
ATH: AT1G30000(MNS3) AT1G51590(MNS1) AT3G21160(MNS2)
LJA: Lj3g3v2055490.1(Lj3g3v2055490.1) Lj4g3v1983210.1(Lj4g3v1983210.1) Lj4g3v1983210.2(Lj4g3v1983210.2) Lj4g3v2139300.1(Lj4g3v2139300.1) Lj6g3v1318420.1(Lj6g3v1318420.1) Lj6g3v1934090.1(Lj6g3v1934090.1)
DOSA: Os04t0606400-01(Os04g0606400) Os05t0209100-01(Os05g0209100)
ATS: 109759492(LOC109759492) 109774541(LOC109774541)
CRE: CHLREDRAFT_178232(AMD1)
VCN: VOLCADRAFT_119746(amd1)
SCE: YJR131W(MNS1) YLR057W(MNL2)
KMX: KLMA_20306(MNL2) KLMA_40509(MNS1)
NCS: NCAS_0J00430(NCAS0J00430) NCAS_0J02160(NCAS0J02160)
NDI: NDAI_0C06450(NDAI0C06450) NDAI_0J02870(NDAI0J02870)
TPF: TPHA_0D00420(TPHA0D00420) TPHA_0L00320(TPHA0L00320)
TBL: TBLA_0B06140(TBLA0B06140) TBLA_0D02500(TBLA0D02500)
TDL: TDEL_0C00640(TDEL0C00640) TDEL_0D00600(TDEL0D00600)
KAF: KAFR_0D01000(KAFR0D01000) KAFR_0E04290(KAFR0E04290)
PIC: PICST_84949(MNS1)
SPAA: SPAPADRAFT_57837(MNS1.1)
CAL: CAALFM_C103730CA(MNS1)
CTEN: CANTEDRAFT_110685(MNS1)
CAUR: QG37_02070
SLB: AWJ20_1894(MNL2) AWJ20_4611(MNS1)
NCR: NCU01059(gh47-3) NCU02235(gh47-6) NCU02778(gh47-1) NCU03134(gh47-2) NCU05836(gh47-4) NCU07067(gh47-5) NCU09028(gh47-8)
NTE: NEUTE1DRAFT111609(NEUTE1DRAFT_111609) NEUTE1DRAFT131655(NEUTE1DRAFT_131655) NEUTE1DRAFT51051(NEUTE1DRAFT_51051) NEUTE1DRAFT58018(NEUTE1DRAFT_58018) NEUTE1DRAFT67654(NEUTE1DRAFT_67654) NEUTE1DRAFT68020(NEUTE1DRAFT_68020) NEUTE1DRAFT74512(NEUTE1DRAFT_74512)
ANG: ANI_1_1456164(An18g06220) ANI_1_1702014(An01g12550) ANI_1_180054(An06g01510) ANI_1_2010184(An04g06990)
SPO: SPAC2E1P5.01c(mns1)
CNE: CNE04550
CNB: CNBE4550
ABP: AGABI1DRAFT115219(AGABI1DRAFT_115219) AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315) AGABI1DRAFT86588(AGABI1DRAFT_86588)
ABV: AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT194179(AGABI2DRAFT_194179) AGABI2DRAFT194180(AGABI2DRAFT_194180) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)
DFA: DFA_08771
SMIN: v1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.016129.t1(symbB.v1.2.016129.t1) v1.2.016133.t1(symbB.v1.2.016133.t1) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1) v1.2.038822.t1(symbB.v1.2.038822.t1)
CAK: Caul_4035
CSE: Cseg_0791
SCT: SCAT_4875
SALJ: SMD11_0332
 » show all
Taxonomy
Reference
1  [PMID:500665]
  Authors
Tabas I, Kornfeld S.
  Title
Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides.
  Journal
J Biol Chem 254:11655-63 (1979)
Reference
2  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J Biol Chem 257:3660-8 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.113
IUBMB Enzyme Nomenclature: 3.2.1.113
ExPASy - ENZYME nomenclature database: 3.2.1.113
BRENDA, the Enzyme Database: 3.2.1.113
CAS: 9068-25-1

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