| Entry |
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| Name |
endo-alpha-sialidase;
endo-N-acylneuraminidase;
endoneuraminidase;
endo-N-acetylneuraminidase;
poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase;
poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase;
endosialidase;
endo-N
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
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| Sysname |
polysialoside (2->8)-alpha-sialosylhydrolase
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| Reaction(IUBMB) |
Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids
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| Comment |
Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetylated substrates. An exo-alpha-sialidase activity is listed as EC 3.2.1.18 exo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase.
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| History |
EC 3.2.1.129 created 1990, modified 1999
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| Reference |
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| Authors |
Finne J, Makela PH. |
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| Title |
Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid. |
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| Journal |
J Biol Chem 260:1265-70 (1985) |
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| Reference |
|
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| Authors |
Hallenbeck PC, Vimr ER, Yu F, Bassler B, Troy FA. |
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| Title |
Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units. |
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| Journal |
J Biol Chem 262:3553-61 (1987) |
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| Reference |
|
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| Authors |
Kitajima K, Inoue S, Inoue Y, Troy FA. |
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| Title |
Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies. |
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| Journal |
J Biol Chem 263:18269-76 (1988) |
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| Reference |
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| Authors |
Kwiatkowski B, Boschek B, Thiele H, Stirm S. |
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| Title |
Endo-N-acetylneuraminidase associated with bacteriophage particles. |
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| Journal |
J Virol 43:697-704 (1982) |
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| Reference |
|
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| Authors |
Pelkonen S, Pelkonen J, Finne J. |
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| Title |
Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins. |
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| Journal |
J Virol 63:4409-16 (1989) |
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| Reference |
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| Authors |
Tomlinson S, Taylor PW. |
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| Title |
Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide. |
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| Journal |
J Virol 55:374-8 (1985) |
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| Reference |
|
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| Authors |
Cabezas JA. |
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| Title |
Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase. |
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| Journal |
Biochem J 278 ( Pt 1):311-2 (1991) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.2.1.129 |
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