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Entry
EC 3.2.1.180                Enzyme                                 

Name
unsaturated chondroitin disaccharide hydrolase;
UGL (ambiguous);
unsaturated glucuronyl hydrolase (ambiguous)
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase
Reaction(IUBMB)
beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
Reaction(KEGG)
(other) R10867
Show
Substrate
beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S;
H2O [CPD:C00001]
Product
5-dehydro-4-deoxy-D-glucuronate [CPD:C04053];
N-acetyl-beta-D-galactosamine-6-O-sulfate
Comment
The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. It prefers the sulfated disaccharides to the unsulfated disaccharides.
History
EC 3.2.1.180 created 2011
Orthology
K18581  unsaturated chondroitin disaccharide hydrolase
Genes
ENT: Ent638_3433
ENC: ECL_04348
ENO: ECENHK_07975
ECLO: ENC_32620
EEC: EcWSU1_03810(ugl)
ENL: A3UG_07925
ECLG: EC036_37430
ECLE: ECNIH2_19740
ECLN: ECNIH4_14665
ECLI: ECNIH5_18500
ECLX: LI66_19250
ECLY: LI62_21180
ECLZ: LI64_18235
CSK: ES15_2575
CTU: CTU_14680(ugl) CTU_30950(ugl)
KOX: KOX_16335
EAE: EAE_03300
EAR: CCG33320
CRO: ROD_35721
RAA: Q7S_09825
PCT: PC1_3952
SGL: SG2119
SOD: Sant_2852
XOR: XOC_2062
VVU: VV2_1092
VVY: VVA1615
GAI: IMCC3135_18785(ugl)
HCH: HCH_02844
AVR: B565_2114
BUT: X994_6498
AFQ: AFA_08200
ODI: ODI_R3778
AVI: Avi_7344
REL: REMIM1_PF00599(ugl)
REP: IE4803_PC00330(ugl)
REI: IE4771_PD00328(ugl)
RLE: pRL120662(ugl)
RLG: Rleg_5051
RHN: AMJ98_PE00413(ugl)
RPHA: AMC79_PD00548(ugl)
RHX: AMK02_PD00271(ugl)
RHK: Kim5_PC00309(ugl)
SHZ: shn_17345
PHL: KKY_2676
BHA: BH2054
BCZ: pE33L466_0349(ugl)
BSE: Bsel_0451
PPY: PPE_02101
PPM: PPSC2_11005(ugl)
PPO: PPM_2109(ugl)
PPOL: X809_11345
PPOY: RE92_01350
PLV: ERIC2_c23760(ugl)
SPY: SPy_0632(ugl)
SPYA: A20_0564c(ugl)
SPG: SpyM3_0446(ugl)
SPF: SpyM51341(ugl)
STG: MGAS15252_0548(ugl)
STX: MGAS1882_0545(ugl)
SOZ: Spy49_0528c(ugl)
STZ: SPYALAB49_000554(ugl)
SPYH: L897_02810
SPN: SP_0322
SPD: SPD_0294
SPR: spr0292(ugl)
SPW: SPCG_0328
SJJ: SPJ_0317
SNV: SPNINV200_02890(ugl)
SPX: SPG_0292
SNT: SPT_0371
SND: MYY_0404
SPNN: T308_01615
SNE: SPN23F02960(ugl)
SPV: SPH_0433
SPP: SPP_0357
SNI: INV104_02680(ugl)
SPNG: HMPREF1038_00371(ugl)
SNP: SPAP_0354
SNX: SPNOXC03320(ugl)
SNU: SPNA45_01715(ugl)
SPNE: SPN034156_13890(ugl)
SPNU: SPN034183_03390(ugl)
SPNM: SPN994038_03270(ugl)
SPNO: SPN994039_03280(ugl)
SAG: SAG1901
SAN: gbs1889
SAGM: BSA_19200
SAGI: MSA_19870
SAGR: SAIL_19180
SAGE: EN72_09990
SAGG: EN73_09075
SAGN: W903_1839
SSB: SSUBM407_0731(ugl)
SSI: SSU1058(ugl)
SSS: SSUSC84_1092(ugl)
SSF: SSUA7_1071(ugl)
SUP: YYK_05030
SSUY: YB51_6075
SUI: SSUJS14_1187(ugl)
SUO: SSU12_1123(ugl)
SSUI: T15_0742
SEZ: Sez_1305
SEQ: SZO_06620
SEQU: Q426_02595
SEU: SEQ_1486
SDS: SDEG_0647
SDA: GGS_0622
SDC: SDSE_0688(ugl)
STK: STP_1172
SIE: SCIM_1354
SIB: SIR_1540
SIU: SII_1526
SANC: SANR_1711
SCG: SCI_1635
SCON: SCRE_1591
SCOS: SCR2_1591
SIK: K710_0211
LSA: LCA_1785
LCA: LSEI_2668
LCB: LCABL_28580(ugl)
LCS: LCBD_2884
LCE: LC2W_2858
LCW: BN194_28050(ugl)
LRL: LC705_02688(ugl)
LRA: LRHK_2797
EFL: EF62_2531
EFQ: DR75_1082
ENE: ENT_22810
EFM: M7W_1124
ECAS: ECBG_01354
MPS: MPTP_0404
MPX: MPD5_1496
CPF: CPF_0400
CPR: CPR_0396
CBEI: LF65_04243
CSS: Cst_c24950(ugl)
CSD: Clst_2389
FPR: FP2_29950
FPA: FPR_25330
BPB: bpr_I2145(ugl88A)
BHU: bhn_I0697
RIX: RO1_22000
RIM: ROI_09920
ERH: ERH_1222
MCD: MCRO_0400(ugl)
MFR: MFE_04690
MFM: MfeM64YM_0605(ugl)
MFP: MBIO_0030
SMA: SAVERM_44
SHY: SHJG_1934
SVE: SVEN_0173
SLD: T261_1741
STRM: M444_04960
SRW: TUE45_pSRc_0381(ugl)
SMAL: SMALA_1040
SLX: SLAV_34445(ugl)
MTS: MTES_2094
AMD: AMED_1525
AMN: RAM_07740
AMM: AMES_1515
AMZ: B737_1516
AOI: AORI_1619
KAL: KALB_342
TTF: THTE_2188
SACI: Sinac_0734
SMF: Smon_0127
BTH: BT_0146
BTHO: Btheta7330_03218(ugl_2)
BVU: BVU_0115
BXY: BXY_41550
BOA: Bovatus_00043(ugl_1)
BCEL: BcellWH2_04821(ugl_5) BcellWH2_04829(ugl_6)
FLN: FLA_3024
FJO: Fjoh_2406
FJG: BB050_00232(ugl_1)
MARM: YQ22_02185
CBAL: M667_19790
CBAT: M666_19770
ZGA: ZOBELLIA_3445(uglA1)
MARF: CJ739_3726
MRO: MROS_2319
HMU: Hmuk_3416
SALI: L593_06510
 » show all
Taxonomy
Reference
1  [PMID:19416976]
  Authors
Maruyama Y, Nakamichi Y, Itoh T, Mikami B, Hashimoto W, Murata K
  Title
Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan.
  Journal
J Biol Chem 284:18059-69 (2009)
DOI:10.1074/jbc.M109.005660
  Sequence
[san:gbs1889] [spy:SPy_0632] [spr:spr0292]
Reference
2  [PMID:21147778]
  Authors
Nakamichi Y, Maruyama Y, Mikami B, Hashimoto W, Murata K
  Title
Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups.
  Journal
J Biol Chem 286:6262-71 (2011)
DOI:10.1074/jbc.M110.182618
  Sequence
[san:gbs1889]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.180
IUBMB Enzyme Nomenclature: 3.2.1.180
ExPASy - ENZYME nomenclature database: 3.2.1.180
BRENDA, the Enzyme Database: 3.2.1.180

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