KEGG   ENZYME: 3.2.1.24Help
Entry
EC 3.2.1.24                 Enzyme                                 

Name
alpha-mannosidase;
alpha-D-mannosidase;
p-nitrophenyl-alpha-mannosidase;
alpha-D-mannopyranosidase;
1,2-alpha-mannosidase;
1,2-alpha-D-mannosidase;
exo-alpha-mannosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-D-mannoside mannohydrolase
Reaction(IUBMB)
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides
Reaction(KEGG)
(other) R08717(G) R08718(G)
Show
Comment
Also hydrolyses alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose.
History
EC 3.2.1.24 created 1961
Pathway
ec00511  Other glycan degradation
Orthology
K01191  alpha-mannosidase
K12311  lysosomal alpha-mannosidase
K12312  epididymis-specific alpha-mannosidase
Genes
HSA: 23324(MAN2B2) 4123(MAN2C1) 4125(MAN2B1)
PTR: 453758(MAN2C1) 455745(MAN2B1) 461102(MAN2B2)
PPS: 100971472(MAN2C1) 100977668(MAN2B1) 100982980(MAN2B2)
GGO: 101136007(MAN2B1) 101141976(MAN2B2) 101144805(MAN2C1)
PON: 100171932(MAN2B2) 100174476(MAN2B1) 100174488(MAN2C1)
NLE: 100586600(MAN2C1) 100588237(MAN2B2) 100598622(MAN2B1)
MCC: 705599(MAN2C1) 710870(MAN2B2) 716173(MAN2B1)
MCF: 101865521(MAN2B2) 102137710(MAN2B1) 102145092(MAN2C1)
CSAB: 103233978(MAN2B1) 103245297(MAN2C1) 103246407(MAN2B2)
RRO: 104661102(MAN2B1) 104667558(MAN2B2) 104676996(MAN2C1)
RBB: 108516085(MAN2B2) 108516997(MAN2C1) 108539608(MAN2B1)
SBQ: 101028592(MAN2C1) 101031183(MAN2B2) 101050078(MAN2B1)
MMU: 17159(Man2b1) 17160(Man2b2) 73744(Man2c1)
RNO: 246136(Man2c1) 360955(Man2b2) 361378(Man2b1)
CGE: 100761822(Man2c1) 100766505(Man2b1) 100770115(Man2b2)
NGI: 103743529(Man2c1) 103750641(Man2b2) 103751895(Man2b1)
HGL: 101705792(Man2b1) 101712594(Man2b2) 101717669(Man2c1)
CCAN: 109681246(Man2b1) 109685194 109687441(Man2b2) 109694117(Man2c1)
TUP: 102483853(MAN2B1) 102500315(MAN2B2) 102501329(MAN2C1)
CFA: 100855835(MAN2B2) 484932(MAN2B1) 488779 611620(MAN2C1)
AML: 100470947(MAN2B1) 100478857(MAN2C1) 105235106(MAN2B2)
UMR: 103658339(MAN2B2) 103679115(MAN2C1) 103682159(MAN2B1)
ORO: 101363484(MAN2B2) 101367441(MAN2B1) 101377330(MAN2C1) 105757097
FCA: 101091532(MAN2B2) 101099049(MAN2C1) 493697(MAN2B1)
PTG: 102949209(MAN2C1) 102970858(MAN2B2) 102971102(MAN2B1)
AJU: 106979389(MAN2C1) 106982716(MAN2B2) 106985939(MAN2B1)
BTA: 107132586 282272(MAN2B1) 523503 532207 541086(MAN2C1) 781835
PHD: 102333692 102336834 102337252(MAN2B1) 102337764(MAN2C1)
SSC: 100156538(MAN2C1) 100518647(MAN2B1) 396847(MAN2B2)
CFR: 102505706(MAN2B2) 102507605(MAN2C1) 102508436(MAN2B1)
CDK: 105087241(MAN2C1) 105104070(MAN2B1) 105106514(MAN2B2)
BACU: 102999718(MAN2C1) 102999783(MAN2B1)
LVE: 103075945(MAN2C1) 103088076(MAN2B1)
OOR: 101269399(MAN2C1) 101285368(MAN2B1)
ECB: 100056382(MAN2B2) 100061610(MAN2C1) 100064359(MAN2B1)
EAI: 106826920(MAN2B1) 106831284(MAN2C1) 106844525(MAN2B2)
MYB: 102243253(MAN2B2) 102255151(MAN2B1) 102255765(MAN2C1)
MYD: 102755574(MAN2B1) 102768293(MAN2C1) 102775261(MAN2B2)
HAI: 109372346(MAN2C1) 109394253(MAN2B1)
RSS: 109440091 109441370 109454954(MAN2B1) 109457829(MAN2C1)
PALE: 102887031(MAN2C1) 102898106(MAN2B1)
LAV: 100658867(MAN2B1) 100664557 100669018(MAN2C1)
MDO: 100010377(MAN2B1) 100019089(MAN2B2) 100030390(MAN2C1)
SHR: 100924862(MAN2B2) 100930413(MAN2B1) 100934233(MAN2C1)
OAA: 100081270(MAN2C1) 100092187(MAN2B2) 103170598(MAN2B1)
GGA: 415306(MAN2C1) 422859(MAN2B2)
MGP: 100547587(MAN2C1) 100549822(MAN2B2)
CJO: 107307162(MAN2B1) 107314023(MAN2B2) 107318587(MAN2C1)
APLA: 101798144(MAN2C1) 101799334(MAN2B2)
ACYG: 106035054(MAN2B2) 106044230(MAN2C1)
TGU: 100228971(MAN2C1) 100229436(MAN2B2)
GFR: 102034050(MAN2C1) 102041009(MAN2B2)
FAB: 101818525(MAN2C1) 101819881(MAN2B2)
PHI: 102101310(MAN2B1) 102105905(MAN2B2) 102110828(MAN2C1)
PMAJ: 107203356(MAN2B2) 107209149(MAN2C1)
CCAE: 111928209(MAN2B2) 111934266(MAN2C1) 111945477
CCW: 104690748(MAN2B2) 104697477(MAN2C1)
FPG: 101910315(MAN2B2) 101918350(MAN2C1) 106112399(MAN2B1)
FCH: 102047733(MAN2C1) 102050942(MAN2B2)
CLV: 102089231(MAN2B2) 102095069(MAN2C1)
EGZ: 104123263(MAN2B2) 104130727(MAN2C1)
AAM: 106496474(MAN2C1) 106498060(MAN2B1) 106498768(MAN2B2)
ASN: 102376538(MAN2B1) 102377901(MAN2C1) 102380537(MAN2B2)
AMJ: 102559547(MAN2C1) 102560214(MAN2B2) 102562074(MAN2B1)
PSS: 102446502(MAN2B1) 102457634(MAN2C1)
CMY: 102934096(MAN2B2) 102934391(MAN2B1) 102946265(MAN2C1)
CPIC: 101942520(MAN2B1) 101948190(MAN2C1) 101951080(MAN2B2)
ACS: 100557773(man2b1) 103282811(man2c1)
PVT: 110082637(MAN2B1) 110086863(MAN2C1)
PBI: 103055862(MAN2C1) 103064652(MAN2B1)
GJA: 107109145(MAN2C1) 107114373(MAN2B1)
XLA: 108698022(man2b2.L) 108711713(man2b1.L) 431951(man2c1.L)
XTR: 100036651(man2c1) 100127706(man2b2) 779924(man2b1)
NPR: 108791058(MAN2B2) 108792711(MAN2C1) 108794969(MAN2B1)
DRE: 100003570(man2b2) 541519(man2b1) 569595(man2c1)
SRX: 107737232(man2b1) 107738048(man2b2) 107751149 107752311 107757760(man2c1)
IPU: 108259485(man2b1) 108267862(man2b2) 108275132(man2c1)
AMEX: 103023374(man2c1) 103033201(man2b1) 103034784(man2b2) 111188897
TRU: 101069902(man2c1) 101073393(man2b1) 101073675(man2b2)
LCO: 104924326(man2c1) 104925274(man2b1) 104927599(man2b2)
NCC: 104942255(man2b1) 104953455(man2c1) 104965483(man2b2)
MZE: 101473033(man2c1) 101479470(man2b2) 101487837(man2b1) 112434922
OLA: 101167078(man2b2) 101168422(man2b1) 101173055(man2c1)
XMA: 102222044(man2b2) 102230364(man2c1) 102232163(man2b1)
PRET: 103466566(man2c1) 103480520(man2b2) 103480745(man2b1)
NFU: 107377316(man2b2) 107388739(man2c1) 107391285(man2b1)
KMR: 108229862(man2c1) 108240322(man2b1) 108247764(man2b2)
LCF: 108880838(man2b1) 108886210(man2c1) 108902497(man2b2)
SDU: 111228669(man2c1) 111235677(man2b2) 111235904(man2b1)
HCQ: 109508516(man2b2) 109509184 109511053(man2b1) 109519453(man2c1)
BPEC: 110163286(man2c1) 110172021(man2b2) 110172144(man2b1)
MALB: 109966470(man2b2) 109970346(man2b1) 109971224(man2c1)
SASA: 100286650(man2b2) 101448032(man2b1) 106584834(man2c1) 106590633 106594313
ELS: 105008269(man2c1) 105012090(man2b1) 105020750(man2b2)
SFM: 108924179(man2b2) 108926522(man2c1) 108927502(man2b1)
LCM: 102355373(MAN2B1) 102360284(MAN2B2) 102361345(MAN2C1)
CMK: 103181335(man2b2) 103191148
CIN: 100176799 100181902(man2c1)
DME: Dmel_CG4606(alpha-Man-IIb) Dmel_CG5322(LManI) Dmel_CG6206(LManII) Dmel_CG9463(LManIII) Dmel_CG9465(LManIV) Dmel_CG9466(LManV) Dmel_CG9468(LManVI)
DSI: Dsimw501_GD19050(Dsim_GD19050) Dsimw501_GD22254(Dsim_GD22254) Dsimw501_GD22379(Dsim_GD22379) Dsimw501_GD22380(Dsim_GD22380) Dsimw501_GD22381(Dsim_GD22381) Dsimw501_GD22383(Dsim_GD22383) Dsimw501_GD23708(Dsim_GD23708)
CEL: CELE_F55D10.1(aman-1)
CBR: CBG14532(Cbr-aman-1)
TSP: Tsp_05942
LJA: Lj0g3v0272729.1(Lj0g3v0272729.1) Lj1g3v1442810.1(Lj1g3v1442810.1) Lj1g3v1442810.2(Lj1g3v1442810.2) Lj1g3v1442810.3(Lj1g3v1442810.3) Lj1g3v1442810.4(Lj1g3v1442810.4) Lj1g3v3904360.1(Lj1g3v3904360.1) Lj1g3v3904360.2(Lj1g3v3904360.2) Lj1g3v3904370.1(Lj1g3v3904370.1)
DOSA: Os10t0140200-01(Os10g0140200) Os11t0525600-01(Os11g0525600)
ATS: 109767527(LOC109767527) 109775477(LOC109775477)
APRO: F751_2582
SCE: YGL156W(AMS1)
ERC: Ecym_3349
NCS: NCAS_0D00720(NCAS0D00720)
NDI: NDAI_0H03450(NDAI0H03450)
TPF: TPHA_0G00880(TPHA0G00880)
TBL: TBLA_0B06110(TBLA0B06110)
TDL: TDEL_0G02410(TDEL0G02410)
KAF: KAFR_0B04640(KAFR0B04640)
PIC: PICST_35546(MLN1) PICST_83621(AMS1)
CAL: CAALFM_C402360WA(AMS1)
CAUR: QG37_06328
SLB: AWJ20_3254(AMS1) AWJ20_4106(AMS1)
NCR: NCU07404(gh38-1)
NTE: NEUTE1DRAFT149864(NEUTE1DRAFT_149864)
SSCK: SPSK_03916
MAW: MAC_01035
MAJ: MAA_05698
CMT: CCM_06392
BFU: BCIN_01g03390(Bcams1)
MBE: MBM_06207
ANI: AN2936.2
ANG: ANI_1_1628024(An02g11720)
ABE: ARB_00520
TVE: TRV_05265
PTE: PTT_07490
ZTR: MYCGRDRAFT_109520(MgAMS1)
SPO: SPAC513.05(ams1)
CNE: CNA06750
CNB: CNBA6560
ABP: AGABI1DRAFT103312(AGABI1DRAFT_103312)
ABV: AGABI2DRAFT121861(AGABI2DRAFT_121861)
DDI: DDB_G0287577(manG) DDB_G0292206(manA)
DFA: DFA_00378(manA) DFA_01603(manG) DFA_02102 DFA_10499(manF)
SMIN: v1.2.017759.t1(symbB.v1.2.017759.t1) v1.2.017760.t1(symbB.v1.2.017760.t1)
SBO: SBO_1171
EEC: EcWSU1_00455(mngB)
ECLY: LI62_02930
CSK: ES15_3284
CKO: CKO_03577
VVY: VVA1394
SAGA: M5M_16545
GAI: IMCC3135_03140(mngB)
ARA: Arad_8466
RLE: pRL120348(ams1)
RLG: Rleg_4705
MMED: Mame_05267(mngB)
JAN: Jann_2057
DSH: Dshi_3007(ybgG)
GKA: GK1902
LMOG: BN389_20330(mngB_3) BN389_20350(manG) BN389_27090
PMW: B2K_10705
LLA: L130682(ypdB)
LLK: LLKF_1611(ypdB)
LLT: CVCAS_1403(ypdB)
LLS: lilo_1415(ypdB)
LLX: NCDO2118_1512(ypdB)
LLW: kw2_1445
LLJ: LG36_0879(ypdB)
LGR: LCGT_0573
LGV: LCGL_0592
SPY: SPy_1604
SPYA: A20_1351
SPS: SPs0564
SPF: SpyM50538
SPYH: L897_06550
SPN: SP_2143
SPD: SPD_1971
SPR: spr1951
SPW: SPCG_2113
SJJ: SPJ_2169
SPX: SPG_2083
SNT: SPT_2156
SND: MYY_2063
SPNN: T308_10270
SPV: SPH_2336
SPP: SPP_2194
SNP: SPAP_2193
SSI: SSU1712
SUP: YYK_08225
SSUT: TL13_1720
SSUI: T15_1989
SGO: SGO_1768
SEZ: Sez_1510
SEQ: SZO_04460
SEQU: Q426_01270
SEU: SEQ_1696
SDS: SDEG_1591
SDA: GGS_1458
SDC: SDSE_1742
SMB: smi_1998
SOR: SOR_1902
STB: SGPB_1528(ypdB)
SCF: Spaf_0257
SIE: SCIM_0568
SIB: SIR_1069
SIU: SII_1090
SIK: K710_0326
STRN: SNAG_1798(mngB)
LPL: lp_3631
LPJ: JDM1_2901
LRH: LGG_02675
EFA: EF1707
EFL: EF62_2083
EFS: EFS1_1462
EFQ: DR75_706
ENE: ENT_11140
EFM: M7W_2514
EMU: EMQU_2664
EDU: LIU_03425
MPX: MPD5_1406
CARC: NY10_795
JDA: BW727_101634(mngB)
CBK: CLL_A2125
CBV: U729_711
ASF: SFBM_0790
CSD: Clst_0990
BPB: bpr_III017(man38A)
BHU: bhn_I0086
CPY: Cphy_1720
THX: Thet_1817
TIT: Thit_1713
APR: Apre_0149
ERH: ERH_0236
LPIL: LIP_1181
MMY: MSC_0845
MMYM: MMS_A0928
MMYI: mycmycITA_00886(mngB)
MML: MLC_7700
MLC: MSB_A0898
MBJ: KQ51_01535(mngB)
MMC: Mmcs_0963
MKM: Mkms_0981
MAB: MAB_4227c
MABB: MASS_4262
MCHE: BB28_21780
MSTE: MSTE_04404
TPR: Tpau_2136
SCO: SCO0948(SCM11.03c)
SMA: SAVERM_1753(ama1) SAVERM_7277(ama2)
SGB: WQO_28465
SALS: SLNWT_1504
SFI: SFUL_6101
SALU: DC74_7128
SALL: SAZ_36955
STRM: M444_06645
SPRI: SPRI_6678
SRW: TUE45_00152(mngB)
SLE: sle_07240(sle_07240)
STRD: NI25_03330
SLAU: SLA_6679
SALJ: SMD11_0768
SLX: SLAV_06720(mngB1)
CMI: CMM_0347(manX) CMM_1259
CMC: CMN_00321(manX) CMN_01229
ART: Arth_0803
ARM: ART_2885
AAU: AAur_1025
ACH: Achl_0920
BCV: Bcav_2999
PAW: PAZ_c00640 PAZ_c15360(manA3)
ACIJ: JS278_00383(mngB)
MPH: MLP_11580
NAL: B005_3452
SEN: SACE_3737(ama2)
KAL: KALB_6746
ACTN: L083_0807
AFS: AFR_13120
SNA: Snas_2861
AHE: Arch_0034
BLJ: BLD_0188(manA1) BLD_0189(manA2) BLD_0191(manA3)
BLB: BBMN68_215(manA1) BBMN68_216(manA2)
BAD: BAD_1238
BADL: BADO_1673
BKS: BBKW_1529
BCAT: BBCT_1335
GVG: HMPREF0421_20907(manA2)
RXY: Rxyl_2051
SYN: slr0323(ams1)
SYZ: MYO_120800(ams1)
SYY: SYNGTS_2060(ams1)
SYT: SYNGTI_2059(ams1)
SYS: SYNPCCN_2058(ams1)
SYQ: SYNPCCP_2058(ams1)
SYJ: D082_29660(ams1)
SYW: SYNW0267
SYC: syc2388_d(ams1)
SYG: sync_0308
SYP: SYNPCC7002_A1252(ams1)
SYNR: KR49_10280
SYND: KR52_01175
TEL: tll0290
THN: NK55_00610(ams1)
LET: O77CONTIG1_02719(mngB)
HHG: XM38_016090(mngB_1)
PMT: PMT_1839
AMR: AM1_6392
MAR: MAE_36540
CYT: cce_1203
TER: Tery_3192
GVI: glr0080
GLJ: GKIL_3259
ANA: all0848
AVA: Ava_4452
NAZ: Aazo_1924
CALH: IJ00_21895
CTHE: Chro_5122
CEO: ETSB_0021
RCA: Rcas_2851
CAU: Caur_1109
ATM: ANT_17550
DGO: DGo_PA0307(ams)
TRA: Trad_0469
TTR: Tter_1501
PSL: Psta_3607
PLM: Plim_0075
TTF: THTE_3520
IPA: Isop_2888
SACI: Sinac_6326
PBU: L21SP3_01716(mngB)
PBP: STSP1_00149(mngB_2) STSP1_01070(mngB_3) STSP1_01818(mngB_4)
PBAS: SMSP2_00007(mngB_1) SMSP2_00591(mngB_4) SMSP2_02982(mngB_10)
GAU: GAU_2046
GBA: J421_3641
BFR: BF0339
BFG: BF638R_0344(man)
BXY: BXY_31640
BCEL: BcellWH2_02713(mngB)
BACC: BRDCF_p1422(ybgG)
PMUC: ING2E5A_0090 ING2E5A_1090(MAN2C1)
PDI: BDI_0244
PSAC: PSM36_1088
PRU: PRU_2181
AFD: Alfi_0429
FAE: FAES_2367
TME: Tmel_1011
TAF: THA_1290
FNO: Fnod_0811
MARN: LN42_06130
DTN: DTL3_0219
KOL: Kole_0478
DTU: Dtur_1758
MFV: Mfer_0546
TVO: TVG0218327(TVG0218327)
PTO: PTO0091
FAI: FAD_1030
CDIV: CPM_0538
PHO: PH0835(PH0835)
PYS: Py04_1184
THS: TES1_1106
STO: STK_10080
SSO: SSO3006
SSOA: SULA_0785
SSOL: SULB_0787
SSOF: SULC_0785
SII: LD85_2653
SIH: SiH_2291
SIR: SiRe_2237
SIC: SiL_2200
AHO: Ahos_0335
TUZ: TUZN_0130
VDI: Vdis_2427
VMO: VMUT_0764
TPE: Tpen_1628
ASC: ASAC_1367
ACIA: SE86_04340
 » show all
Taxonomy
Reference
1  [PMID:5905120]
  Authors
Li YT.
  Title
Presence of alpha-D-mannosidic linkage in glycoproteins. Liberation of d-mannose from various glycoproteins by alpha-mannosidase isolated from jack bean meal.
  Journal
J Biol Chem 241:1010-2 (1966)
Reference
2  [PMID:6428944]
  Authors
Winchester B.
  Title
Role of alpha-D-mannosidases in the biosynthesis and catabolism of glycoproteins.
  Journal
Biochem Soc Trans 12:522-4 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.24
IUBMB Enzyme Nomenclature: 3.2.1.24
ExPASy - ENZYME nomenclature database: 3.2.1.24
BRENDA, the Enzyme Database: 3.2.1.24
CAS: 9025-42-7

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