KEGG   ENZYME: 3.2.1.33Help
Entry
EC 3.2.1.33                 Enzyme                                 

Name
amylo-alpha-1,6-glucosidase;
amylo-1,6-glucosidase;
dextrin 6-alpha-D-glucosidase;
amylopectin 1,6-glucosidase;
dextrin-1,6-glucosidase;
glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin
Reaction(KEGG)
(other) R02109 R06158(G)
Show
Comment
This enzyme hydrolyses an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.
History
EC 3.2.1.33 created 1965, modified 2000
Orthology
K01196  glycogen debranching enzyme
Genes
HSA: 178(AGL)
PTR: 469392(AGL)
PPS: 100970156(AGL)
GGO: 101124513(AGL)
PON: 100462408(AGL)
NLE: 100607309(AGL)
MCC: 710910(AGL)
MCF: 102141897(AGL)
CSAB: 103224377(AGL)
RRO: 104659344 104659377 104673244(AGL)
RBB: 108524169(AGL)
CJC: 100393172(AGL)
SBQ: 101049181(AGL)
MMU: 77559(Agl)
RNO: 362029(Agl)
CGE: 100772306(Agl)
NGI: 103734650(Agl)
HGL: 101717426(Agl)
OCU: 100009066(AGL)
TUP: 102486200(AGL)
CFA: 479931(AGL)
AML: 100478160(AGL)
UMR: 103669338(AGL)
ORO: 101374591(AGL)
FCA: 101086077(AGL)
PTG: 102963048(AGL)
AJU: 106976407(AGL)
BTA: 517397(AGL)
BOM: 102270729(AGL)
BIU: 109556025(AGL)
PHD: 102343238(AGL)
CHX: 102178874(AGL)
OAS: 101111501(AGL)
CFR: 102515206(AGL)
CDK: 105085047(AGL)
BACU: 103004932(AGL)
LVE: 103085945(AGL)
OOR: 101281941(AGL)
ECB: 100050695(AGL)
EPZ: 103540873(AGL)
EAI: 106837787(AGL)
MYB: 102252935(AGL)
MYD: 102755651(AGL)
HAI: 109374607(AGL)
RSS: 109455463(AGL)
PALE: 102880281(AGL)
LAV: 100659336(AGL)
TMU: 101343034
MDO: 100032952(AGL)
SHR: 100934625(AGL) 105750616
OAA: 100081547(AGL)
GGA: 424474(AGL)
MGP: 100551267(AGL)
CJO: 107317427(AGL)
APLA: 101794374(AGL)
ACYG: 106039458(AGL)
TGU: 100217722(AGL)
GFR: 102034726(AGL)
FAB: 101815607(AGL)
PHI: 102100235(AGL)
PMAJ: 107208094(AGL)
CCAE: 111932714(AGL)
CCW: 104695373(AGL)
FPG: 101911809(AGL)
FCH: 102054834(AGL)
CLV: 102084204(AGL)
EGZ: 104134027(AGL)
AAM: 106499569(AGL)
ASN: 102369862(AGL)
AMJ: 102570293(AGL)
PSS: 102446584(AGL)
CMY: 102947904(AGL)
CPIC: 101952161(AGL)
ACS: 100565632(agl)
PVT: 110086303(AGL)
PBI: 103050283(AGL)
GJA: 107119045(AGL)
XLA: 108715682 779381(agl.L)
XTR: 780065(agl)
NPR: 108799770(AGL)
DRE: 567798(agla)
SANH: 107693749(agl) 107697901
TRU: 101071621(agl)
LCO: 104934804(agl)
MZE: 101474686(agl)
OLA: 101163765(agl)
XMA: 102230673(agl)
PRET: 103479203(agl)
NFU: 107384360(agl)
KMR: 108248238(agl)
CSEM: 103396633(agl)
SDU: 111233892(agl) 111237619
HCQ: 109521259(agl)
BPEC: 110155709(agl)
MALB: 109953042(agl)
ELS: 105007682(agl)
LCM: 102354072(AGL)
CMK: 103174627(agl)
CIN: 100181714
SPU: 592988
APLC: 110977745
DME: Dmel_CG9485(CG9485)
DSI: Dsimw501_GD11587(Dsim_GD11587)
DWI: 6640393
MDE: 101894191
AAG: 5572509
AME: 411488
BIM: 100741946
BTER: 100651379
SOC: 105196942
AEC: 105146017
ACEP: 105623566
PBAR: 105431025
HST: 105185268
DQU: 106741907
CFO: 105249351
LHU: 105678778
PGC: 109855360
PCF: 106786622
NVI: 100117168
MDL: 103573379
TCA: 662526
DPA: 109539064
NVL: 108558748
BMOR: 101746747
PMAC: 106709834
PRAP: 110998633
DNX: 107168952
CLEC: 106663696
ZNE: 110832695
FCD: 110853518
CEL: CELE_R06A4.8(agl-1)
CBR: CBG11104
TSP: Tsp_07883
MYI: 110465491
OBI: 106878848
LAK: 106156752
SHX: MS3_00794
EPA: 110253248
HMG: 100212805
AQU: 100641813
SCE: YPR184W(GDB1)
ERC: Ecym_2815
KMX: KLMA_40472(GDB1)
NCS: NCAS_0A15250(NCAS0A15250)
NDI: NDAI_0J00180(NDAI0J00180)
TPF: TPHA_0I03290(TPHA0I03290)
TBL: TBLA_0J00110(TBLA0J00110)
TDL: TDEL_0H00300(TDEL0H00300)
KAF: KAFR_0B00300(KAFR0B00300)
PIC: PICST_74319(GDB1)
CAL: CAALFM_C405140CA(GDB1)
CAUR: QG37_02109
SLB: AWJ20_1844(GDB1)
NCR: NCU00743
NTE: NEUTE1DRAFT149613(NEUTE1DRAFT_149613)
MGR: MGG_00063
SSCK: SPSK_00070
MAW: MAC_03960
MAJ: MAA_06996
CMT: CCM_03522
BFU: BCIN_01g10310(Bcgdb1)
MBE: MBM_04879
ANG: ANI_1_788014(An01g06120)
PBL: PAAG_12154(PAAG_06098)
ABE: ARB_07179
TVE: TRV_07707
PTE: PTT_07191
CNE: CNJ03090
CNB: CNBJ0440
ABP: AGABI1DRAFT118950(AGABI1DRAFT_118950)
ABV: AGABI2DRAFT206172(AGABI2DRAFT_206172)
DDI: DDB_G0287569(agl)
DFA: DFA_01273(agl)
EHI: EHI_098360(77.t00009)
SMIN: v1.2.030503.t1(symbB.v1.2.030503.t1)
 » show all
Taxonomy
Reference
1
  Authors
Brown, D.H. and Brown, B.I.
  Title
Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and oligo-1,4->1,4-glucanotransferase (II).
  Journal
Methods Enzymol 8:515-524 (1966)
Reference
2  [PMID:5424210]
  Authors
Lee EY, Carter JH, Nielsen LD, Fischer EH.
  Title
Purification and properties of yeast amylo-1,6-glucosidase--oligo-1,4 leads to 1,4-glucantransferase.
  Journal
Biochemistry 9:2347-55 (1970)
Reference
3  [PMID:5805288]
  Authors
Nelson TE, Kolb E, Larner J.
  Title
Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
  Journal
Biochemistry 8:1419-28 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.33
IUBMB Enzyme Nomenclature: 3.2.1.33
ExPASy - ENZYME nomenclature database: 3.2.1.33
BRENDA, the Enzyme Database: 3.2.1.33
CAS: 9012-47-9

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