KEGG   ENZYME: 3.2.1.35Help
Entry
EC 3.2.1.35                 Enzyme                                 

Name
hyaluronoglucosaminidase;
hyaluronidase;
hyaluronoglucosidase;
chondroitinase;
chondroitinase I
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
hyaluronate 4-glycanohydrolase
Reaction(IUBMB)
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
Reaction(KEGG)
(other) R07824(G) R07825(G) R10905(G)
Show
Comment
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
History
EC 3.2.1.35 created 1965, modified 1976, modified 2001 (EC 3.2.1.34 created 1965, incorporated 1972)
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01197  hyaluronoglucosaminidase
K19031  cell migration-inducing and hyaluronan-binding protein
K22144  cell surface hyaluronidase
Genes
HSA: 23553(HYAL4) 23670(CEMIP2) 3373(HYAL1) 57214(CEMIP) 6677(SPAM1) 8372(HYAL3) 8692(HYAL2)
PTR: 453585(CEMIP) 460389(HYAL3) 460390(HYAL1) 460391(HYAL2) 464523(CEMIP2) 472497(HYAL4) 472498(SPAM1) 738764
PPS: 100973013(CEMIP) 100975669(HYAL2) 100976003(HYAL1) 100976800(HYAL3) 100979818 100980408(SPAM1) 100989231 100992689(TMEM2)
GGO: 101123757 101123816(HYAL2) 101130227(CEMIP) 101130666(TMEM2) 101150470 101150849(SPAM1) 101151269(HYAL1) 101152349(HYAL3)
PON: 100441244(CEMIP) 100441700(CEMIP2) 100453650(HYAL2) 100455010(HYAL1) 100455370(HYAL3) 100458070 100461750 100462117(SPAM1)
NLE: 100581375(TMEM2) 100582240(HYAL4) 100582343 100582574(SPAM1) 100590133(HYAL3) 100591153(HYAL1) 100592159(HYAL2) 100601667(CEMIP)
MCC: 106996913(HYAL3) 696128(HYAL4) 696249(SPAM1) 696805 702484(HYAL2) 702850(HYAL1) 703378(TMEM2) 717880(CEMIP)
MCF: 101926741(SPAM1) 102119956 102120586(HYAL4) 102129860(CEMIP) 102135597(TMEM2) 102141387(HYAL1) 102146623(HYAL2) 107126372(HYAL3)
CSAB: 103219570(TMEM2) 103226818 103226819 103226820(SPAM1) 103227668(HYAL1) 103227669 103227673(HYAL2) 103245218(CEMIP)
RRO: 104666011 104666012(SPAM1) 104666017 104666991(HYAL2) 104667013(HYAL1) 104667040(HYAL3) 104672135(TMEM2) 104678101(CEMIP)
RBB: 108522869(TMEM2) 108523239(SPAM1) 108523241 108523242(HYAL4) 108526954(HYAL2) 108526956(HYAL1) 108526957(HYAL3) 108538642(CEMIP)
CJC: 100405923(HYAL1) 100406523(HYAL3) 100406710(CEMIP) 100407141(HYAL2) 100410718(SPAM1) 100410994(TMEM2) 100411084(HYAL4)
SBQ: 101031601(TMEM2) 101033104(CEMIP) 101036461 101037627(HYAL2) 101039509(HYAL1) 101040064(HYAL3) 101053467(SPAM1) 101053778(HYAL4)
MMU: 109685(Hyal3) 15586(Hyal1) 15587(Hyal2) 20690(Spam1) 74409(Hyal6) 74468(Hyal5) 77042(Hyal4) 80982(Cemip) 83921(Cemip2)
RNO: 117037(Spam1) 300993(Hyal3) 308797(Cemip) 309400(Tmem2) 367166(Hyal1) 404783(Hyal4) 500051(Hyal6) 500052(Hyal5) 64468(Hyal2)
HGL: 101700218(Spam1) 101701149(Hyal1) 101701738(Hyal3) 101709759(Hyal2) 101712540(Tmem2) 101714296(Cemip) 101723286(Hyal4) 101723647
OCU: 100009375(HYAL2) 100009391(SPAM1) 100337723 100337977 100339482(HYAL3) 100339732(HYAL1) 100343109(TMEM2) 100353125(CEMIP)
TUP: 102480682 102481108(SPAM1) 102481532(HYAL4) 102482361 102483390(HYAL2) 102484339(HYAL1) 102484391(CEMIP) 102485187(HYAL3) 102499468(TMEM2)
CFA: 475211(SPAM1) 475212 484171(TMEM2) 484760(HYAL2) 488766(CEMIP) 608602(HYAL1) 608620(HYAL3) 609321
AML: 100465816(TMEM2) 100467994(CEMIP) 100470607(HYAL1) 100470685(SPAM1) 100472672 100481098(HYAL3) 109489578(HYAL4)
UMR: 103660291(CEMIP) 103663256(TMEM2) 103674798(HYAL2) 103674799(HYAL3) 103675086(HYAL1) 103676616 103676617(SPAM1) 103676687
ORO: 101364702 101365006(SPAM1) 101366496 101369009(HYAL3) 101369610(HYAL1) 101370114(HYAL2) 101376897(TMEM2) 101382154(CEMIP)
FCA: 101088960(TMEM2) 101092920(HYAL3) 101093011 101094000(HYAL2) 101094181(CEMIP) 101095484(HYAL4) 101095731(SPAM1)
PTG: 102952897(CEMIP) 102964157 102964452(HYAL4) 102964738(SPAM1) 102965224(HYAL1) 102966380(HYAL3) 102971665(TMEM2)
AJU: 106965962(CEMIP) 106970630(SPAM1) 106970631(HYAL4) 106970632 106979259(HYAL3) 106979262(HYAL1) 106985808(TMEM2)
BTA: 281838(HYAL2) 353352(SPAM1) 509761 515397(HYAL1) 515491(CEMIP2) 518161(HYAL4) 519047(CEMIP) 527125 616562(HYAL3)
BOM: 102267588 102275599(HYAL3) 102275634 102275878(HYAL1) 102276163(HYAL2) 102278293(CEMIP) 102278479(TMEM2) 102284407(HYAL4) 102284688(SPAM1)
BIU: 109557586(HYAL4) 109557587(SPAM1) 109557935 109558119 109562950(TMEM2) 109575672(CEMIP) 109576069(HYAL2) 109576071(HYAL1) 109576073(HYAL3)
PHD: 102315956(HYAL4) 102316306(SPAM1) 102317411(CEMIP) 102322162 102322508 102323828(HYAL3) 102324175(HYAL1) 102324536(HYAL2) 102326860(TMEM2)
CHX: 100860748(PH-20) 102168417 102168691(SPAM1) 102168908(TMEM2) 102172212(HYAL2) 102172770(HYAL3) 102173238(HYAL1) 102175527(CEMIP) 102189274(HYAL4)
OAS: 101101889 101102143 101102701(TMEM2) 101106519(HYAL4) 101107188 101116178(CEMIP) 101121207(HYAL1) 101121461(HYAL3) 443154(HYAL2)
SSC: 100516588(TMEM2) 100524837(HYAL4) 100738461(CEMIP) 397074(SPAM1) 404696(HYAL3) 404697(HYAL2) 404698(HYAL1)
CFR: 102504111(SPAM1) 102504354 102508028(TMEM2) 102521183(CEMIP) 102521347(HYAL1) 102521929(HYAL3) 102522934(HYAL4)
CDK: 105085347 105085422 105085423(SPAM1) 105087442(HYAL1) 105087477(HYAL3) 105094739(CEMIP) 105106250(TMEM2)
BACU: 103002718(CEMIP) 103005390(HYAL3) 103006722(HYAL1) 103007213(HYAL2) 103007386(TMEM2) 103009506(HYAL4) 103009600(SPAM1)
LVE: 103071921(HYAL3) 103072374(HYAL1) 103073012(HYAL2) 103079092(CEMIP) 103082114(SPAM1) 103082392(HYAL4) 103083035(TMEM2)
OOR: 101272873(TMEM2) 101276998(HYAL3) 101277665(HYAL1) 101277905(HYAL2) 101280772(CEMIP) 101281301(SPAM1) 101281553(HYAL4)
ECB: 100051243(SPAM1) 100053052(CEMIP) 100055623(TMEM2) 100056514 100061845(HYAL2) 100061939(HYAL3) 106783049
EPZ: 103544212(SPAM1) 103546741(TMEM2) 103552969(CEMIP) 103557348(HYAL3) 103557349 103560648(HYAL4)
MYB: 102239190(HYAL1) 102249798(HYAL4) 102250717(HYAL3) 102251014(HYAL2) 102253690(TMEM2) 102257934(SPAM1) 102262042
MYD: 102754556(HYAL3) 102754833(HYAL2) 102770889 102770967(TMEM2) 102772512(HYAL1) 102773736(HYAL4) 102774302(SPAM1)
HAI: 109372568(SPAM1) 109372572(HYAL4) 109375181(HYAL3) 109375791(HYAL2) 109375816(HYAL1) 109381501(CEMIP) 109387007(TMEM2)
RSS: 109443435(HYAL2) 109443436(HYAL1) 109443438(HYAL3) 109446935(TMEM2) 109453649(CEMIP) 109457266(SPAM1) 109457276(HYAL4)
PALE: 102878728(HYAL3) 102878975(HYAL1) 102879396(HYAL2) 102891124(SPAM1) 102891363(HYAL4) 102893602(CEMIP2) 102895289(CEMIP)
LAV: 100661612(HYAL4) 100664537(TMEM2) 100664953(CEMIP) 100667479(SPAM1) 100669188(HYAL2) 100669471(HYAL1)
MDO: 100013352(CEMIP) 100015067(TMEM2) 100016989 100017029(HYAL4) 100017190(SPAM1) 100028570(HYAL3) 100028614(HYAL1) 100028633(HYAL2) 100031013
OAA: 100073876(TMEM2) 100076503 100076538(HYAL4) 100076578(SPAM1) 100078017(HYAL1) 100078126(HYAL2)
GGA: 100859903(HYAL3) 105667218(HYAL6) 415476(CEMIP) 415478 415908(HYAL2) 417749(SPAM1) 426739(HYAL1) 427250(TMEM2)
MGP: 100541798(SPAM1) 100541954 100542084(HYAL1) 100542238(HYAL2) 100544349(CEMIP) 100544508 104909302(HYAL3) 104915066
CJO: 107306191(TMEM2) 107308697(SPAM1) 107308927 107318794(CEMIP) 107318795 107319561(HYAL2) 107319564(HYAL1) 107319647(HYAL3)
APLA: 101790915(TMEM2) 101795794(HYAL1) 101799098 101799286(HYAL4) 101800183(HYAL2) 101802129(CEMIP) 101804475 106014259(SPAM1)
TGU: 100219184(HYAL1) 100224131 100224380(TMEM2) 100227026(HYAL4) 100228780(HYAL2) 100229824(SPAM1) 100230220(CEMIP)
GFR: 102032659(CEMIP) 102035392(HYAL3) 102037819(SPAM1) 102042845 102043012(HYAL4) 102044638(TMEM2) 102044902(HYAL2) 102045068(HYAL1)
FAB: 101807037(HYAL3) 101807147(KIAA1199) 101808121(HYAL4) 101808315 101810515(TMEM2) 101810841 101816626(SPAM1) 101820358(HYAL2) 101820552(HYAL1)
PHI: 102101272(HYAL1) 102102212(TMEM2) 102105429(HYAL3) 102110886(CEMIP) 102111253(SPAM1) 102112351(HYAL2) 102114277 102114472(HYAL4)
CCW: 104683216(HYAL1) 104683435(HYAL2) 104683951 104685247(TMEM2) 104686823(SPAM1) 104686903(HYAL4)
FPG: 101911022(HYAL3) 101911065(CEMIP) 101911469(TMEM2) 101918475 101919114(SPAM1) 101919242(HYAL1) 101919279(HYAL4) 101919413(HYAL2) 101919451
FCH: 102047510(TMEM2) 102047789 102048877(HYAL1) 102049052(HYAL2) 102050381(HYAL3) 102052271 102052442(HYAL4) 102052609(SPAM1) 102055479(CEMIP)
EGZ: 104123845(TMEM2) 104125665 104125689(SPAM1) 104126661 104126687(HYAL1) 104126688(HYAL2) 104130811 104130945(CEMIP)
ASN: 102370740(CEMIP) 102373756 102375861(CEMIP2) 102378863(HYAL1) 102379112(HYAL2) 102383208(HYAL3) 102384522 102384773 112550426(SPAM1)
AMJ: 102557643(HYAL3) 102560730 102567712(CEMIP) 102574610 102574830(HYAL1) 102574839(HYAL4) 102575064(HYAL2) 102576224(TMEM2) 109284220(SPAM1)
CMY: 102931696(SPAM1) 102932459 102933270 102933500(HYAL4) 102935818(HYAL3) 102936282(HYAL2) 102942858(CEMIP) 102944161(HYAL1) 102944539(TMEM2) 102946634
CPIC: 101935741(TMEM2) 101937040 101938579 101939191(CEMIP) 101939316(HYAL2) 101941627(HYAL3) 101942498 101942774(HYAL4) 101944873(HYAL1) 101946842(SPAM1) 103306294
GJA: 107105438(CEMIP) 107106781(TMEM2) 107108394 107108395 107116007(HYAL1) 107116008(HYAL2) 107118546 107118632(HYAL3)
XLA: 100337508(hyal2.L) 108706972(tmem2.S) 108711150(hyal4.L) 108711451 108711452(cemip.L) 108712855(cemip.S) 108714490(tmem2.L) 108714598(hyal1.L) 380470(hyal2.S) 398285(spam1.L)
XTR: 100037890(hyal4) 100144942(hyal2) 100379691(tmem2) 100486024(spam1) 100491930 100492102(cemip) 100498156(hyal1)
DRE: 100003660(cemip) 100004557(hyal3) 108181664 559228(hyal2b) 566851(cemip2) 567869(hyal2a) 664772(hyal1) 791189(hyal6)
CIN: 100186831
SKO: 100377225
AAG: 5578235
AME: 406146
BIM: 100743050
BTER: 100651053
SOC: 105196779
AEC: 105148714
ACEP: 105623333
PBAR: 105426307
HST: 105188713
CFO: 105251112
LHU: 105669752
PGC: 109856266
NVI: 100115714
TCA: 661685
DPA: 109537076
NVL: 108567699
BMOR: 101735594
PRAP: 111001369
API: 100166159
DNX: 107173173
CEL: CELE_T22C8.2(chhy-1)
CBR: CBG00535
HMG: 100204026
XCC: XCC2028
XCB: XC_2155
XCP: XCR_2312
XCV: XCV4043
XAX: XACM_3822
XAC: XAC3928
XOO: XOO0215(Chb)
XOM: XOO0189(XOO0189)
XOP: PXO_03654
XOR: XOC_4258
XPH: XppCFBP6546_14760(XppCFBP6546P_14760)
STAX: MC45_11905
AAY: WYH_03091
PPY: PPE_00341
PPM: PPSC2_01915(hyl)
PPO: PPM_0365(hyl)
PPOL: X809_01520
PPOY: RE92_10015
PLV: ERIC2_c20510(nagJ)
SPY: SPy_0701(hylP1) SPy_1600
SPYM: M1GAS476_1381(hyl)
SPYA: A20_1348c(hyl) A20_1471c
SPM: spyM18_0770(hylP) spyM18_1606(hyl)
SPG: SpyM3_1214(hylP.4) SpyM3_1294(hyl)
SOZ: Spy49_1236c(hyl)
SEZ: Sez_1507(hylZ)
SEQ: SZO_04490
SEZO: SeseC_02032(hya)
SEQU: Q426_01285
SDS: SDEG_1588(hyl)
SDA: GGS_1455(hyl)
SDC: SDSE_1739(hyl)
EFU: HMPREF0351_12988(hyl)
CML: BN424_3030(hyl)
CARC: NY10_1498
CPR: CPR_1248
CBV: U729_414
TSH: Tsac_2289
APR: Apre_0148
MCD: MCRO_0688(nagH)
MCY: MCYN_0715(MCYN0715)
SGR: SGR_4877
SGB: WQO_11075
SVE: SVEN_2438
SALS: SLNWT_7238
SFI: SFUL_2231
STRM: M444_12985
SLE: sle_45640(sle_45640)
SRN: A4G23_01727(nagJ)
STRD: NI25_36120
SLAU: SLA_2333
SALJ: SMD11_4482(hya)
SFK: KY5_2790
KSK: KSE_54890
ARX: ARZXY2_3886(hya)
LMOI: VV02_00325
CACN: RN83_03935
KFL: Kfla_3229
SEN: SACE_7066
AOI: AORI_3373(hya)
KAL: KALB_2454
ACTI: UA75_14920
ACAD: UA74_14330
AHG: AHOG_13470(nagJ)
SNA: Snas_2451
BBF: BBB_1496(nagH) BBB_1610(nagH)
TTR: Tter_0116
AMU: Amuc_0052
AGL: PYTT_0357
BTH: BT_4395
BFR: BF4022
BVU: BVU_2069
PDI: BDI_1142
CPI: Cpin_5708
ZPR: ZPR_3254
PMO: Pmob_0472
DTN: DTL3_1494
KOL: Kole_1175
 » show all
Taxonomy
Reference
1
  Authors
Meyer, K., Hoffman, P. and Linker, A.
  Title
Hyaluronidases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 447-460.
Reference
2
  Authors
Rapport, M.M., Myer, K. and Linker, A.
  Title
Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase.
  Journal
J Am Chem Soc 73:2416-2420 (1951)
Reference
3  [PMID:13271353]
  Authors
WEISSMANN B.
  Title
The transglycosylative action of testicular hyaluronidase.
  Journal
J Biol Chem 216:783-94 (1955)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.35
IUBMB Enzyme Nomenclature: 3.2.1.35
ExPASy - ENZYME nomenclature database: 3.2.1.35
BRENDA, the Enzyme Database: 3.2.1.35
CAS: 37326-33-3

DBGET integrated database retrieval system