KEGG   ENZYME: 3.2.1.46Help
Entry
EC 3.2.1.46                 Enzyme                                 

Name
galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
D-galactosyl-N-acylsphingosine galactohydrolase
Reaction(IUBMB)
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]
Reaction(KEGG)
Substrate
D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
ceramide [CPD:C00195]
Comment
cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.46 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01202  galactosylceramidase
Genes
HSA: 2581(GALC)
PTR: 736519(GALC)
PPS: 100986325(GALC)
GGO: 101137325(GALC)
PON: 100458475(GALC)
NLE: 100587134(GALC)
MCC: 693322(GALC)
MCF: 101925411(GALC)
CSAB: 103229484(GALC)
RRO: 104668560(GALC)
RBB: 108522791(GALC)
CJC: 100412515(GALC)
SBQ: 101046485(GALC)
MMU: 14420(Galc)
RNO: 314360(Galc)
CGE: 100751905(Galc)
NGI: 103744394(Galc)
HGL: 101721890(Galc)
CCAN: 109700619(Galc)
OCU: 100351605(GALC)
TUP: 102488515(GALC)
CFA: 403916(GALC)
AML: 100481872(GALC)
UMR: 103670525(GALC)
ORO: 101363316(GALC)
FCA: 101084116(GALC)
PTG: 102954621(GALC)
AJU: 106989912(GALC)
BTA: 533428(GALC)
BOM: 102281426(GALC)
BIU: 109565404(GALC)
PHD: 102336792(GALC)
CHX: 102188052(GALC)
OAS: 101118106(GALC)
SSC: 100156917(GALC)
CFR: 102522511(GALC)
CDK: 105105382(GALC)
BACU: 103010897(GALC)
LVE: 103089768(GALC)
OOR: 101279086(GALC)
ECB: 100034130(GALC)
EPZ: 103551800(GALC)
EAI: 106834294(GALC)
MYB: 102257416(GALC)
MYD: 102765447(GALC)
HAI: 109382678(GALC)
RSS: 109454064(GALC)
PALE: 102880991(GALC)
LAV: 100658478(GALC)
TMU: 101340632
MDO: 100019504(GALC)
SHR: 100915302(GALC)
OAA: 100081052(GALC)
GGA: 423394(GALC)
MGP: 100549468(GALC)
CJO: 107315242(GALC)
APLA: 101796301(GALC)
ACYG: 106033531(GALC)
TGU: 100224899(GALC)
GFR: 102034660(GALC)
FAB: 101810873(GALC)
PHI: 102113858(GALC)
PMAJ: 107205967(GALC)
CCAE: 111929558(GALC)
CCW: 104688651(GALC)
FPG: 101914337(GALC)
FCH: 102059116(GALC)
CLV: 102098299(GALC)
EGZ: 104126309(GALC)
AAM: 106483066(GALC)
ASN: 102374264(GALC)
AMJ: 102575324(GALC)
PSS: 102445851(GALC)
CMY: 102931374(GALC)
CPIC: 101952897(GALC)
ACS: 100564761(galc)
PVT: 110090986(GALC)
PBI: 103054662(GALC)
GJA: 107123345(GALC)
XLA: 446948(galc.L)
XTR: 779723(galc)
NPR: 108792556(GALC)
DRE: 406385(galcb) 449649(galca)
IPU: 108258153(galc) 108269778
TRU: 101074089(galc)
LCO: 104928261(galc)
NCC: 104943827(galc)
MZE: 101473828(galc)
OLA: 101163287(galc)
XMA: 102226991(galc)
PRET: 103458970(galc)
KMR: 108245031(galc)
CSEM: 103384287(galc)
LCF: 108897907(galc)
SDU: 111225520(galc)
HCQ: 109522741(galc)
BPEC: 110165479(galc)
MALB: 109959716(galc)
SASA: 100195231(galc)
ELS: 105024731(galc) 105024733
SFM: 108924125(galc)
LCM: 102356089(GALC)
CMK: 103185410(galc)
CIN: 100182893(galc)
APLC: 110973820
SKO: 100376265
CEL: CELE_C29E4.10(C29E4.10)
CRG: 105334333
MYI: 110460487
OBI: 106876977
AQU: 100640150
SMIN: v1.2.004702.t1(symbB.v1.2.004702.t1) v1.2.024887.t1(symbB.v1.2.024887.t1) v1.2.025387.t1(symbB.v1.2.025387.t1)
 » show all
Taxonomy
Reference
1  [PMID:5320641]
  Authors
Brady RO, Gal AE, Kanfer JN, Bradley RM.
  Title
The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.
  Journal
J Biol Chem 240:3766-70 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.46
IUBMB Enzyme Nomenclature: 3.2.1.46
ExPASy - ENZYME nomenclature database: 3.2.1.46
BRENDA, the Enzyme Database: 3.2.1.46
CAS: 9027-89-8

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