KEGG   ENZYME: 3.2.1.62Help
Entry
EC 3.2.1.62                 Enzyme                                 

Name
glycosylceramidase;
phlorizin hydrolase;
phloretin-glucosidase;
glycosyl ceramide glycosylhydrolase;
cerebrosidase;
phloridzin beta-glucosidase;
lactase-phlorizin hydrolase;
phloridzin glucosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
glycosyl-N-acylsphingosine glycohydrolase
Reaction(IUBMB)
a glycosyl-N-acylsphingosine + H2O = a ceramide + a sugar [RN:R01501]
Reaction(KEGG)
Substrate
glycosyl-N-acylsphingosine [CPD:C03701];
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
sugar [CPD:C11477]
Comment
Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase.
History
EC 3.2.1.62 created 1972, modified 1976
Orthology
K01229  lactase-phlorizin hydrolase
Genes
HSA: 3938(LCT)
PTR: 459633(LCT)
PPS: 100993974(LCT)
GGO: 101136936(LCT)
PON: 100450303(LCT)
NLE: 100602088(LCT)
MCC: 707761(LCT)
MCF: 102141036(LCT)
CSAB: 103216991(LCT)
RRO: 104665436(LCT)
RBB: 108539586(LCT)
CJC: 100408648(LCT)
SBQ: 101044226(LCT)
MMU: 226413(Lct)
RNO: 116569(Lct)
CGE: 100766856(Lct)
NGI: 103734619(Lct)
HGL: 101697396(Lct)
OCU: 100009256(LPH) 100352497(LCT) 100353264
TUP: 102470311(LCT)
CFA: 483898(LCT)
AML: 100484153(LCT)
UMR: 103667712(LCT)
ORO: 101373825(LCT)
FCA: 101092452(LCT)
PTG: 102949288(LCT)
AJU: 106969449(LCT)
BTA: 514332(LCT)
BOM: 102279578(LCT)
BIU: 109568203(LCT)
PHD: 102331503(LCT)
CHX: 102170472(LCT)
OAS: 101104042(LCT)
SSC: 100625807(LCT) 100625897
CFR: 102513047(LCT)
CDK: 105092305(LCT)
BACU: 103003658(LCT)
LVE: 103074579(LCT)
OOR: 101270599(LCT)
ECB: 100055369(LCT)
EPZ: 103548925(LCT)
EAI: 106836543(LCT)
MYB: 102246527(LCT)
MYD: 102761793(LCT)
HAI: 109392715(LCT)
RSS: 109447104(LCT)
PALE: 102887366(LCT)
LAV: 100661599(LCT)
TMU: 101348169
MDO: 100016393(LCT)
SHR: 100933904(LCT)
OAA: 100084941(LCT)
GGA: 424294(LCT)
MGP: 100540699(LCT)
CJO: 107316868(LCT)
APLA: 101799746(LCT)
ACYG: 106039329(LCT)
TGU: 100229941(LCT)
GFR: 102041259(LCT)
FAB: 101814034(LCT)
PHI: 102100057(LCT)
PMAJ: 107207677(LCT)
CCAE: 111932317(LCT)
CCW: 104694217(LCT)
FPG: 101921531(LCT)
FCH: 102058755(LCT)
CLV: 102086420(LCT)
EGZ: 104129535(LCT)
AAM: 106498455(LCT)
ASN: 102370133(LCT)
AMJ: 102576031(LCT)
PSS: 102456860(LCT)
CMY: 102946778(LCT)
CPIC: 101933763(LCT)
ACS: 103279188(lct)
PVT: 110071879(LCT)
PBI: 103054678(LCT)
GJA: 107115411(LCT)
XLA: 100127248(lct.1.L) 100127291(lct.2.L)
XTR: 100145766(lct.2) 101732850
DRE: 796436(lct)
IPU: 108266116(lct)
AMEX: 103029218(lct)
TRU: 101066689
OLA: 101171223(lct)
NFU: 107389384(lct)
CSEM: 103392433(lct)
HCQ: 109515508(lct)
BPEC: 110153127 110161869(lct)
MALB: 109966332(lct)
SASA: 106586119(lct)
OTW: 112235127(lct)
ELS: 105005862(lct)
SFM: 108928209(lct)
LCM: 102361997(LCT)
CMK: 103180388(lct)
SPU: 587972
TCA: 661002
BMOR: 101742223
PXY: 105380834
DNX: 107169514
CRG: 105317658
OBI: 106882977
ADF: 107339079
VAR: 108339449
CCAJ: 109798565
HBR: 110666867
SIND: 105164621
DCT: 110113139
 » show all
Taxonomy
Reference
1  [PMID:4752949]
  Authors
Leese HJ, Semenza G.
  Title
On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase.
  Journal
J Biol Chem 248:8170-3 (1973)
Reference
2  [PMID:5082068]
  Authors
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G.
  Title
A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase.
  Journal
Eur J Clin Invest 2:326-31 (1972)
DOI:10.1111/j.1365-2362.1972.tb00658.x
Reference
3  [PMID:5774775]
  Authors
Malathi P, Crane RK.
  Title
Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane.
  Journal
Biochim Biophys Acta 173:245-56 (1969)
DOI:10.1016/0005-2736(69)90108-4
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.62
IUBMB Enzyme Nomenclature: 3.2.1.62
ExPASy - ENZYME nomenclature database: 3.2.1.62
BRENDA, the Enzyme Database: 3.2.1.62
CAS: 9033-10-7

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