KEGG   ENZYME: 3.2.2.19Help
Entry
EC 3.2.2.19                 Enzyme                                 

Name
[protein ADP-ribosylarginine] hydrolase;
ADP-ribose-L-arginine cleavage enzyme;
ADP-ribosylarginine hydrolase;
Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase;
protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Reaction(IUBMB)
(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine [RN:R07626];
(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine [RN:R01886]
Reaction(KEGG)
Substrate
protein-Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C16011];
H2O [CPD:C00001];
Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C01201]
Product
ADP-D-ribose [CPD:C00301];
protein-L-arginine [CPD:C00613];
L-arginine [CPD:C00062]
Comment
The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.
History
EC 3.2.2.19 created 1989, modified 2004
Orthology
K01245  ADP-ribosylarginine hydrolase
Genes
HSA: 141(ADPRH)
PTR: 470893(ADPRH)
PPS: 100968536(ADPRH)
GGO: 101150307(ADPRH)
PON: 100440790(ADPRH)
NLE: 100602502(ADPRH)
MCC: 712562(ADPRH)
MCF: 102138957(ADPRH)
CSAB: 103228225(ADPRH)
RRO: 104657619(ADPRH)
RBB: 108541872(ADPRH)
CJC: 100391892(ADPRH)
SBQ: 101054411(ADPRH)
MMU: 11544(Adprh)
RNO: 25371(Adprh)
CGE: 100761196(Adprh)
NGI: 103741941(Adprh)
HGL: 101705433(Adprh)
CCAN: 109694540(Adprh)
OCU: 100354201(ADPRH)
TUP: 102473277(ADPRH)
CFA: 100855709(ADPRH)
AML: 100479971(ADPRH)
UMR: 103678790(ADPRH)
ORO: 101363531(ADPRH)
BTA: 525738(ADPRH)
BOM: 102277051(ADPRH)
BIU: 109577238(ADPRH)
PHD: 102338571(ADPRH)
CHX: 102168665(ADPRH)
OAS: 101106222(ADPRH)
SSC: 100153158(ADPRH)
CFR: 102524560(ADPRH)
CDK: 105090325(ADPRH)
BACU: 103002571(ADPRH)
LVE: 103086426(ADPRH)
OOR: 101281103(ADPRH)
ECB: 100070997(ADPRH)
EPZ: 103547420(ADPRH)
EAI: 106823717(ADPRH)
MYB: 102245153(ADPRH)
MYD: 102755321(ADPRH)
HAI: 109388460(ADPRH)
RSS: 109446339(ADPRH)
PALE: 102881506(ADPRH)
LAV: 100660874(ADPRH)
TMU: 101350795
MDO: 100016348(ADPRH)
SHR: 100927416(ADPRH)
GGA: 426545(ADPRHL)
MGP: 100540673(ADPRH) 104916026
CJO: 107322016(ADPRH) 107325783
APLA: 101795135(ADPRH)
ACYG: 106039946(ADPRH)
TGU: 100226233(ADPRH)
GFR: 102040950(ADPRH)
FAB: 101806150(ADPRH) 101808754
PHI: 102101461(ADPRH) 102112496
PMAJ: 107209760(ADPRH) 107212272
CCAE: 111937223 111941677(ADPRH)
CCW: 104689397(ADPRH) 104695645
FPG: 101915329(ADPRH)
FCH: 102058856(ADPRH)
CLV: 102084426 102087478(ADPRH)
EGZ: 104123010(ADPRH)
AAM: 106490658(ADPRH)
ASN: 102386159(ADPRH)
AMJ: 102562154(ADPRH) 102567119
PSS: 102452391(ADPRH)
CMY: 102934922(ADPRH)
CPIC: 101931729(ADPRH) 101936712
ACS: 100563208(adprh) 100565391
PVT: 110078575 110088473(ADPRH)
PBI: 103049757(ADPRH) 103050993
GJA: 107117555(ADPRH) 107122687
XLA: 108704185 432184 447554(adprh.S) 495095(adprh)
XTR: 100135190(adprh) 493544(adprh)
DRE: 445059(adprh)
SRX: 107726130
SANH: 107704615(adprh)
CCAR: 109110344
IPU: 100528393(adprh) 108274007
LCO: 104926880(adprh) 109141701
NCC: 104947179(adprh)
MZE: 101482423(adprh)
OLA: 101172847(adprh)
CSEM: 103381590
LCF: 108890419(adprh)
SDU: 111219950(adprh)
MALB: 109973617(adprh)
SASA: 100194575(adprh) 106579059 106586332(adprh)
SFM: 108930637(adprh) 108933024
LCM: 102353586 102354521(ADPRH)
MYI: 110453922
EPA: 110239995
ADF: 107341614
HMG: 100197201
AQU: 100637875
DDI: DDB_G0289675(adprh)
DFA: DFA_04483(adprh)
 » show all
Taxonomy
Reference
1  [PMID:2994036]
  Authors
Moss J, Jacobson MK, Stanley SJ.
  Title
Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme.
  Journal
Proc Natl Acad Sci U S A 82:5603-7 (1985)
DOI:10.1073/pnas.82.17.5603
Reference
2  [PMID:1375222]
  Authors
Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC.
  Title
Molecular and immunological characterization of ADP-ribosylarginine hydrolases.
  Journal
J Biol Chem 267:10481-8 (1992)
  Sequence
[rno:25371]
Reference
3  [PMID:10358013]
  Authors
Konczalik P, Moss J.
  Title
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases.
  Journal
J Biol Chem 274:16736-40 (1999)
DOI:10.1074/jbc.274.24.16736
Reference
4  [PMID:8349667]
  Authors
Takada T, Iida K, Moss J.
  Title
Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.
  Journal
J Biol Chem 268:17837-43 (1993)
  Sequence
[hsa:141] [mmu:11544]
Reference
5  [PMID:8678289]
  Authors
Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M.
  Title
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
  Journal
Anal Biochem 231:115-22 (1995)
DOI:10.1006/abio.1995.1510
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.19
IUBMB Enzyme Nomenclature: 3.2.2.19
ExPASy - ENZYME nomenclature database: 3.2.2.19
BRENDA, the Enzyme Database: 3.2.2.19
CAS: 98668-52-1

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