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Entry
EC 3.2.2.26                 Enzyme                                 

Name
futalosine hydrolase;
futalosine nucleosidase;
MqnB
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
futalosine ribohydrolase
Reaction(IUBMB)
futalosine + H2O = dehypoxanthine futalosine + hypoxanthine [RN:R08587]
Reaction(KEGG)
Substrate
futalosine [CPD:C16999];
H2O [CPD:C00001]
Product
dehypoxanthine futalosine [CPD:C17010];
hypoxanthine [CPD:C00262]
Comment
This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.
History
EC 3.2.2.26 created 2008
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K11783  futalosine hydrolase
Genes
AQL: BXU06_16280
GSU: GSU0453(mqnB)
GSK: KN400_0426(mqnB)
GME: Gmet_3381(mqnB)
GUR: Gura_0685
GLO: Glov_0458
GBM: Gbem_0598(mqnB)
GEO: Geob_0898(mqnB)
GEM: GM21_0612
GEB: GM18_3755
PCA: Pcar_3117(mqnB)
PPD: Ppro_3274
DES: DSOUD_0020(mqnB)
DEU: DBW_3613
DVU: DVU3178
DVL: Dvul_0209
DVM: DvMF_2491
DDE: Dde_3188
DDS: Ddes_1911
DMA: DMR_35800
DGG: DGI_2626
DEF: CNY67_02625(mqnB)
DTR: RSDT_0457(mqnB)
DAS: Daes_0800
DPI: BN4_11672
PPRF: DPRO_2568(mqnB)
DBA: Dbac_3009
DRT: Dret_2414
DSF: UWK_02144
DOL: Dole_1278
SFU: Sfum_1814
DBR: Deba_2375
BHA: BH2690
BCL: ABC0988
BKW: BkAM31D_01800(mqnB)
BBEV: BBEV_2867
BSE: Bsel_0478
PPY: PPE_03890
PPO: PPM_4092(M1_4500)
PPOL: X809_36560
PPOY: RE92_16780
PMW: B2K_40540
PSAB: PSAB_23170
PRI: PRIO_6458
PSWU: SY83_01250
ASOC: CB4_02170(mqnB)
DRM: Dred_3235
DAE: Dtox_4200
DAU: Daud_0261
SGY: Sgly_3170
SCO: SCO4327(SCD12A.10c)
SALB: XNR_2324
SMA: SAVERM_3905(mqnB)
SGR: SGR_3174
SGB: WQO_19855
SCT: SCAT_2423
SFA: Sfla_2741
SBH: SBI_04915
SHY: SHJG_4799
SVE: SVEN_4139
STRP: F750_4057
SFI: SFUL_4158
SALU: DC74_4819
SALL: SAZ_25775
SLV: SLIV_16760(mqnB)
STRE: GZL_04008
SLD: T261_3374
STRM: M444_16080
SAMB: SAM23877_3378(mqnB)
SPRI: SPRI_4149
SRW: TUE45_04208(mqnB)
SLE: sle_39460(sle_39460)
SRN: A4G23_02416(mqnB)
STRD: NI25_21950
SMAL: SMALA_3437
SLAU: SLA_4259
SALJ: SMD11_2817
SLX: SLAV_17350(mqnB)
SFK: KY5_3626
KSK: KSE_44340
FAL: FRAAL6734
ACE: Acel_0106
SAQ: Sare_0500
MIL: ML5_0694
AMS: AMIS_3780
ASE: ACPL_536
ACTN: L083_0510
AFS: AFR_02110
ACTS: ACWT_0421
CAI: Caci_8090
SNA: Snas_5857
DRA: DR_1664
DGE: Dgeo_0447
DEZ: DKM44_00105(mqnB)
DWU: DVJ83_05855(mqnB)
TRA: Trad_1280
TTH: TT_C0188
TTJ: TTHA0556
TAQ: TO73_1348
TBC: A0O31_01992(mqnB)
MRB: Mrub_0986
RBA: RB1081
PIR: VN12_00835(mqnB)
FSC: FSU_2393
BACC: BRDCF_p520
DORI: FH5T_01435
MBAS: ALGA_1067
CPI: Cpin_6958
CBAE: COR50_09000(mqnB)
FLN: FLA_0160
SGN: SGRA_1216(mtnN)
PHE: Phep_4151
PGS: CPT03_17650(mqnB)
MUC: MuYL_0222
TTK: TST_1334(mtnN)
CTHI: THC_1277
 » show all
Taxonomy
Reference
1  [PMID:18801996]
  Authors
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
  Title
An alternative menaquinone biosynthetic pathway operating in microorganisms.
  Journal
Science 321:1670-3 (2008)
DOI:10.1126/science.1160446
  Sequence
[sco:SCO4327] [ttj:TTHA0556]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.26
IUBMB Enzyme Nomenclature: 3.2.2.26
ExPASy - ENZYME nomenclature database: 3.2.2.26
BRENDA, the Enzyme Database: 3.2.2.26

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