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Entry
EC 3.2.2.29                 Enzyme                                 

Name
thymine-DNA glycosylase;
mismatch-specific thymine-DNA glycosylase;
mismatch-specific thymine-DNA N-glycosylase;
hTDG;
hsTDG;
TDG;
thymine DNA glycosylase;
G/T glycosylase;
uracil/thymine DNA glycosylase;
T:G mismatch-specific thymidine-DNA glycosylase;
G:T mismatch-specific thymine DNA-glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction(IUBMB)
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
EC 3.2.2.29 created 2009
Orthology
K20813  thymine-DNA glycosylase
Genes
HSA: 6996(TDG)
PTR: 452188(TDG)
PPS: 100980045(TDG)
GGO: 101130939(TDG)
PON: 100452129(TDG)
NLE: 100598008(TDG)
MCC: 700061(TDG)
MCF: 101866862(TDG)
CSAB: 103238979(TDG)
RRO: 104657468(TDG)
RBB: 108544252(TDG)
CJC: 100398863(TDG)
SBQ: 101038544(TDG)
MMU: 21665(Tdg) 545124(Tdg-ps)
RNO: 114521(Tdg)
NGI: 103742144(Tdg)
HGL: 101703457(Tdg)
CCAN: 109675720(Tdg)
OCU: 100355930(TDG)
TUP: 102496464(TDG)
CFA: 475448(TDG)
AML: 100478809(TDG)
UMR: 103676486(TDG)
ORO: 101384203(TDG)
FCA: 101082502(TDG)
PTG: 102969722(TDG)
AJU: 106971878(TDG)
BTA: 517825(TDG)
BOM: 102268073(TDG)
BIU: 109559456(TDG)
PHD: 102315739(TDG)
CHX: 102189100(TDG)
OAS: 101123623(TDG)
SSC: 100155184(TDG)
CFR: 102518004(TDG)
CDK: 105097477(TDG)
BACU: 103009535(TDG)
LVE: 103081678(TDG)
OOR: 101289555(TDG)
ECB: 100053458(TDG)
EPZ: 103562005(TDG)
EAI: 106846788(TDG)
MYB: 102253254(TDG)
MYD: 102751349(TDG)
HAI: 109387776(TDG)
RSS: 109445801(TDG)
PALE: 102888665(TDG)
LAV: 100671433(TDG)
TMU: 101341896
MDO: 100021839(TDG)
SHR: 100918146 100920398(TDG)
OAA: 100076258(TDG)
GGA: 395510(TDG)
MGP: 100545972(TDG)
CJO: 107314745(TDG)
APLA: 101802890(TDG)
ACYG: 106035893(TDG)
TGU: 100219529 100222509(TDG)
GFR: 102035597(TDG)
FAB: 101813146(TDG)
PHI: 102112018(TDG)
PMAJ: 107204445(TDG)
CCAE: 111935992(TDG)
CCW: 104696236(TDG)
FPG: 101912560(TDG)
FCH: 102049571(TDG)
CLV: 102092705(TDG) 110358245
EGZ: 104132738(TDG)
AAM: 106488729(TDG)
ASN: 102368125(TDG)
AMJ: 102567507(TDG)
PSS: 102452289(TDG)
CMY: 102941802(TDG)
CPIC: 101935707(TDG)
ACS: 100567264(tdg)
PVT: 110084774(TDG)
PBI: 103058406(TDG)
GJA: 107119987(TDG)
XLA: 399413(tdg.S)
XTR: 448432(tdg)
NPR: 108789008(TDG)
DRE: 553789(tdg.1) 558951(tdg.2)
IPU: 108269283(tdg) 108269360(Tdg)
LCO: 104937569(tdg) 104937575
OLA: 101155844(tdg) 101162834
XMA: 102223318 102226852(tdg)
PRET: 103465701 103465703(tdg)
NFU: 107388368(tdg) 107388370
KMR: 108245713(tdg) 108245718
ELS: 105009540(tdg) 105009541
LCM: 102350121(TDG)
CMK: 103179828(tdg)
CIN: 104266612
SPU: 586471
APLC: 110982095
DME: Dmel_CG1981(Thd1)
DER: 6555861
DSI: Dsimw501_GD24378(Dsim_GD24378)
TCA: 658765
DPA: 109541058
NVL: 108565870
BMOR: 101735453
PMAC: 106707729
PRAP: 110991611
HAW: 110382226
API: 100164619
DNX: 107168052
ZNE: 110831912
FCD: 110859143
TUT: 107360226
TSP: Tsp_05734
CRG: 105344766
MYI: 110448845
OBI: 106876312
SHX: MS3_01752
AQU: 100639845
CAL: CAALFM_C306530WA(CaO19.7442)
CAUR: QG37_05972
NCR: NCU02098
MGR: MGG_11518
SSCK: SPSK_00047
MAW: MAC_06227
MAJ: MAA_00707
CMT: CCM_05432
MBE: MBM_03404
ANI: AN5479.2
ANG: ANI_1_2406074(An08g10020)
ABE: ARB_07552
TVE: TRV_07036
PTE: PTT_08555
SPO: SPCC965.05c(thp1)
CNE: CNF00820
CNB: CNBF3900
ABP: AGABI1DRAFT69564(AGABI1DRAFT_69564)
ABV: AGABI2DRAFT200628(AGABI2DRAFT_200628)
MGL: MGL_2765
SPAR: SPRG_01482
 » show all
Taxonomy
Reference
1  [PMID:10767625]
  Authors
Waters TR, Swann PF
  Title
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
  Journal
Mutat Res 462:137-47 (2000)
DOI:10.1016/S1383-5742(00)00031-4
Reference
2  [PMID:8407958]
  Authors
Neddermann P, Jiricny J
  Title
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
  Journal
J Biol Chem 268:21218-24 (1993)
  Sequence
[hsa:6996]
Reference
3  [PMID:9685338]
  Authors
Waters TR, Swann PF
  Title
Kinetics of the action of thymine DNA glycosylase.
  Journal
J Biol Chem 273:20007-14 (1998)
DOI:10.1074/jbc.273.32.20007
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.29
IUBMB Enzyme Nomenclature: 3.2.2.29
ExPASy - ENZYME nomenclature database: 3.2.2.29
BRENDA, the Enzyme Database: 3.2.2.29

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