KEGG   ENZYME: 3.3.1.2Help
Entry
EC 3.3.1.2                  Enzyme                                 

Name
S-adenosyl-L-methionine hydrolase (L-homoserine-forming);
S-adenosylmethionine cleaving enzyme;
methylmethionine-sulfonium-salt hydrolase;
adenosylmethionine lyase;
adenosylmethionine hydrolase;
S-adenosylmethionine hydrolase;
S-adenosyl-L-methionine hydrolase
Class
Hydrolases;
Acting on ether bonds;
Thioether and trialkylsulfonium hydrolases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine [RN:R00175]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
H2O [CPD:C00001]
Product
L-homoserine [CPD:C00263];
S-methyl-5'-thioadenosine [CPD:C00170]
Comment
Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.1.8, S-adenosyl-L-methionine hydrolase (adenosine-forming).
History
EC 3.3.1.2 created 1972, modified 1976, modified 2018
Orthology
K21534  S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
Reference
1  [PMID:5849106]
  Authors
Mazelis M, Levin B, Mallinson N.
  Title
Decomposition of methyl methionine sulfonium salts by a bacterial enzyme.
  Journal
Biochim Biophys Acta 105:106-14 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 3.3.1.2
IUBMB Enzyme Nomenclature: 3.3.1.2
ExPASy - ENZYME nomenclature database: 3.3.1.2
BRENDA, the Enzyme Database: 3.3.1.2
CAS: 37288-62-3

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