KEGG   ENZYME: 3.3.2.2Help
Entry
EC 3.3.2.2                  Enzyme                                 

Name
lysoplasmalogenase;
alkenylglycerophosphocholine hydrolase;
alkenylglycerophosphoethanolamine hydrolase;
1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname
lysoplasmalogen aldehydohydrolase
Reaction(IUBMB)
(1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine [RN:R02745];
(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine [RN:R03415]
Reaction(KEGG)
Substrate
1-(1-alkenyl)-sn-glycero-3-phosphocholine [CPD:C04517];
H2O [CPD:C00001];
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine [CPD:C04635]
Product
aldehyde [CPD:C00071];
sn-glycero-3-phosphocholine [CPD:C00670];
sn-glycero-3-phosphoethanolamine [CPD:C01233]
Comment
Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine.
History
EC 3.3.2.2 created 1972, modified 1976, (EC 3.3.2.5 created 1984, incorporated 2016), modified 2016
Pathway
ec00565  Ether lipid metabolism
Orthology
K18575  alkenylglycerophosphocholine hydrolase
Genes
HSA: 255043(TMEM86B)
PTR: 456297(TMEM86B)
PPS: 100985350(TMEM86B)
GGO: 101134478(TMEM86B)
PON: 100448045(TMEM86B)
NLE: 100597527(TMEM86B)
MCC: 699222(TMEM86B)
MCF: 102126102(TMEM86B)
CSAB: 103235296(TMEM86B)
RRO: 104674761(TMEM86B)
RBB: 108542528(TMEM86B)
CJC: 100388681(TMEM86B)
SBQ: 101047356(TMEM86B)
MMU: 68255(Tmem86b)
MCAL: 110297428(Tmem86b)
MPAH: 110336976(Tmem86b)
RNO: 690610(Tmem86b)
MUN: 110561057(Tmem86b)
CGE: 100771800(Tmem86b)
NGI: 103744859(Tmem86b)
HGL: 101720540(Tmem86b)
CCAN: 109696265(Tmem86b)
OCU: 100354255(TMEM86B)
TUP: 102498612(TMEM86B)
CFA: 611345(TMEM86B)
VVP: 112909324(TMEM86B)
AML: 100477670(TMEM86B)
UMR: 103680265(TMEM86B)
UAH: 113247424(TMEM86B)
ORO: 101385614(TMEM86B)
ELK: 111139581
FCA: 101092067(TMEM86B)
PTG: 102961296(TMEM86B)
PPAD: 109259907(TMEM86B)
AJU: 106980918(TMEM86B)
BTA: 518466(TMEM86B)
BOM: 102265175(TMEM86B)
BIU: 109571855(TMEM86B)
BBUB: 102415924(TMEM86B)
CHX: 102186626(TMEM86B)
OAS: 101121701(TMEM86B)
SSC: 100514582(TMEM86B)
CFR: 102512804(TMEM86B)
CDK: 105098739(TMEM86B)
BACU: 103006787(TMEM86B)
LVE: 103082812(TMEM86B)
OOR: 101275562(TMEM86B)
DLE: 111181022(TMEM86B)
PCAD: 102985211(TMEM86B)
ECB: 100055488(TMEM86B)
EPZ: 103562865(TMEM86B)
EAI: 106840930(TMEM86B)
MYD: 102757075(TMEM86B)
MNA: 107541331(TMEM86B)
HAI: 109373772(TMEM86B)
DRO: 112313458(TMEM86B)
PALE: 102878082(TMEM86B)
RAY: 107515388(TMEM86B)
MJV: 108388698(TMEM86B)
LAV: 100671261(TMEM86B)
TMU: 101361536
MDO: 103100945(TMEM86B)
PCW: 110192255 110220258(TMEM86B)
ASN: 102387730(TMEM86B)
AMJ: 102558009(TMEM86B)
PVT: 110078564(TMEM86B)
TSR: 106538703
DRE: 751651(tmem86b)
IPU: 108256452(TMEM86B)
PHYP: 113528449
EEE: 113589869
NCC: 104942715
MZE: 101486306
ONL: 100694713
OLA: 101155934
XMA: 102233773
XCO: 114160008
PRET: 103469090
CVG: 107095140(tmem86b)
NFU: 107376661(tmem86b)
KMR: 108242939
ALIM: 106528140(tmem86b)
CSEM: 103392979
LCF: 108881012
SDU: 111230304
HCQ: 109514858
MALB: 109958883
SASA: 106606413
OTW: 112237781
ELS: 109614544
SFM: 108941811
PRAP: 111002984
TNL: 113500329
 » show all
Taxonomy
Reference
1  [PMID:13783189]
  Authors
WARNER HR, LANDS WE.
  Title
The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether.
  Journal
J Biol Chem 236:2404-9 (1961)
Reference
2  [PMID:17805898]
  Authors
Ellingson JS, Lands WE
  Title
Phospholipid reactivation of plasmalogen metabolism.
  Journal
Lipids 3:111-20 (1968)
DOI:10.1007/BF02531727
Reference
3  [PMID:7239443]
  Authors
Gunawan J, Debuch H.
  Title
Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes.
  Journal
Hoppe Seylers Z Physiol Chem 362:445-52 (1981)
Reference
4  [PMID:3753461]
  Authors
Arthur G, Page L, Mock T, Choy PC.
  Title
The catabolism of plasmenylcholine in the guinea pig heart.
  Journal
Biochem J 236:475-80 (1986)
Reference
5  [PMID:21515882]
  Authors
Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz MS
  Title
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that  catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.
  Journal
J Biol Chem 286:24916-30 (2011)
DOI:10.1074/jbc.M111.247163
  Sequence
[hsa:255043]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.2
IUBMB Enzyme Nomenclature: 3.3.2.2
ExPASy - ENZYME nomenclature database: 3.3.2.2
BRENDA, the Enzyme Database: 3.3.2.2
CAS: 37288-65-6

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