KEGG   ENZYME: 3.4.11.15Help
Entry
EC 3.4.11.15                Enzyme                                 

Name
aminopeptidase Y;
aminopeptidase Co;
aminopeptidase (cobalt-activated);
lysyl aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferentially, release of N-terminal lysine
Comment
Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28
History
EC 3.4.11.15 created 1989, modified 1997
Orthology
K01264  aminopeptidase Y
Genes
SCE: YBR286W(APE3)
AGO: AGOS_ADR123W
ERC: Ecym_6317
KLA: KLLA0_D06424g
KMX: KLMA_20821(APE3)
LTH: KLTH0H10054g
VPO: Kpol_1027p12
ZRO: ZYRO0G21208g
CGR: CAGL0G07623g
NCS: NCAS_0B07580(NCAS0B07580)
NDI: NDAI_0B04920(NDAI0B04920)
TPF: TPHA_0I01120(TPHA0I01120)
TBL: TBLA_0C02710(TBLA0C02710)
TDL: TDEL_0D01650(TDEL0D01650)
KAF: KAFR_0A03620(KAFR0A03620)
PIC: PICST_89245(APE3.1)
CAL: CAALFM_C208800CA(APE3)
CAUR: QG37_01387
SLB: AWJ20_3460(APE3)
MGR: MGG_09692
SSCK: SPSK_07399
MAW: MAC_03330
MAJ: MAA_07115
CMT: CCM_05888
BFU: BCIN_15g01050(Bcape3)
MBE: MBM_01335
ANI: AN3918.2
ANG: ANI_1_196034(An03g01660)
PNO: SNOG_01220 SNOG_13567(SNOG_13566)
PTE: PTT_11069
SRO: Sros_0793
 » show all
Taxonomy
Reference
1  [PMID:6758786]
  Authors
Achstetter T, Ehmann C, Wolf DH.
  Title
Aminopeptidase Co, a new yeast peptidase.
  Journal
Biochem Biophys Res Commun 109:341-7 (1982)
DOI:10.1016/0006-291X(82)91726-0
Reference
2  [PMID:8175799]
  Authors
Yasuhara T, Nakai T, Ohashi A.
  Title
Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.
  Journal
J Biol Chem 269:13644-50 (1994)
  Sequence
[sce:YBR286W]
Reference
3  [PMID:8175800]
  Authors
Nishizawa M, Yasuhara T, Nakai T, Fujiki Y, Ohashi A.
  Title
Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase.
  Journal
J Biol Chem 269:13651-5 (1994)
  Sequence
[sce:YBR286W]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.15
IUBMB Enzyme Nomenclature: 3.4.11.15
ExPASy - ENZYME nomenclature database: 3.4.11.15
BRENDA, the Enzyme Database: 3.4.11.15
CAS: 114796-97-3

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