KEGG   ENZYME: 3.4.11.26Help
Entry
EC 3.4.11.26                Enzyme                                 

Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573  intermediate cleaving peptidase 55
Genes
CRE: CHLREDRAFT_172074
BPG: Bathy01g04420
SCE: YER078C(ICP55)
AGO: AGOS_ACL028W
ERC: Ecym_8027
KLA: KLLA0_C07645g
KMX: KLMA_40410(ICP55)
LTH: KLTH0A04950g
VPO: Kpol_411p9
ZRO: ZYRO0C08822g
NCS: NCAS_0E03450(NCAS0E03450)
NDI: NDAI_0A03130(NDAI0A03130)
TPF: TPHA_0P00720(TPHA0P00720)
TBL: TBLA_0F01960(TBLA0F01960)
TDL: TDEL_0H01760(TDEL0H01760)
KAF: KAFR_0L01090(KAFR0L01090)
CAL: CAALFM_C303560WA(CaO19.354)
CAUR: QG37_05795
SLB: AWJ20_1960(ICP55)
NCR: NCU05971
NTE: NEUTE1DRAFT124894(NEUTE1DRAFT_124894)
MGR: MGG_00596
SSCK: SPSK_00770
MAW: MAC_02737
MAJ: MAA_02070
CMT: CCM_04066
MBE: MBM_06434
ANI: AN1780.2
ANG: ANI_1_928094(An11g06960)
ABE: ARB_05294
TVE: TRV_02331
PTE: PTT_13396
SPO: SPAC12B10.05(icp55)
CNE: CNC05670
CNB: CNBC1520
ABP: AGABI1DRAFT64099(AGABI1DRAFT_64099)
ABV: AGABI2DRAFT219147(AGABI2DRAFT_219147)
 » show all
Taxonomy
Reference
1  [PMID:19720832]
  Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
  Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
  Journal
J Biol Chem 284:30200-8 (2009)
DOI:10.1074/jbc.M109.034694
  Sequence
[sce:YER078C]
Reference
2  [PMID:19837041]
  Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
  Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
  Journal
Cell 139:428-39 (2009)
DOI:10.1016/j.cell.2009.07.045
  Sequence
[sce:YER078C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.26
IUBMB Enzyme Nomenclature: 3.4.11.26
ExPASy - ENZYME nomenclature database: 3.4.11.26
BRENDA, the Enzyme Database: 3.4.11.26

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