KEGG   ENZYME: 3.4.14.1Help
Entry
EC 3.4.14.1                 Enzyme                                 

Name
dipeptidyl-peptidase I;
cathepsin C;
dipeptidyl aminopeptidase I;
dipeptidyl transferase;
cathepsin C;
dipeptidyl transferase;
dipeptide arylamidase I;
DAP I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro
Comment
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).
History
EC 3.4.14.1 created 1961 as EC 3.4.4.9, transferred 1972 to EC 3.4.14.1
Orthology
K01275  cathepsin C
Genes
HSA: 1075(CTSC)
PTR: 451469(CTSC)
PPS: 100987211(CTSC)
GGO: 101146804(CTSC)
PON: 100172530(CTSC)
NLE: 100599280(CTSC)
MCC: 705320(CTSC)
MCF: 102137896(CTSC)
CSAB: 103248190(CTSC)
RRO: 104657430(CTSC)
RBB: 108518788 108539152(CTSC)
CJC: 100400437(CTSC)
SBQ: 101042299(CTSC)
MMU: 13032(Ctsc)
RNO: 25423(Ctsc)
CGE: 100769144(Ctsc)
NGI: 103742959(Ctsc)
HGL: 101697606(Ctsc)
CCAN: 109701576(Ctsc)
OCU: 100101594(CTSC)
TUP: 102488201(CTSC)
CFA: 403458(CTSC)
AML: 100464355(CTSC)
UMR: 103675365 103675378(CTSC)
ORO: 101371731(CTSC)
FCA: 101092140(CTSC)
PTG: 102956745(CTSC)
AJU: 106967745(CTSC)
BTA: 352958(CTSC)
BOM: 102272716(CTSC)
BIU: 109554360(CTSC)
PHD: 102316892(CTSC)
CHX: 102190937(CTSC)
OAS: 101112686(CTSC)
SSC: 100522387(CTSC)
CFR: 102510887(CTSC)
BACU: 103017877(CTSC)
LVE: 103089091(CTSC)
ECB: 100060401(CTSC)
EPZ: 103547853(CTSC)
EAI: 106848234(CTSC)
MYB: 102242588(CTSC)
MYD: 102764432(CTSC)
HAI: 109383277(CTSC)
RSS: 109451405(CTSC)
PALE: 102893721(CTSC)
LAV: 100676360(CTSC)
TMU: 101360788
MDO: 100010333 100010381(CTSC)
SHR: 100914125(CTSC)
OAA: 100081326(CTSC)
GGA: 419014(CTSC)
MGP: 100551142(CTSC)
CJO: 107308454(CTSC)
APLA: 101805141(CTSC)
ACYG: 106034176(CTSC)
TGU: 100230748(CTSC)
GFR: 102035213(CTSC)
FAB: 101814128(CTSC)
PHI: 102104432(CTSC)
PMAJ: 107211449(CTSC)
CCAE: 111922076 111924959(CTSC)
CCW: 104690321(CTSC)
FPG: 101918722(CTSC)
FCH: 102058646(CTSC)
CLV: 102095055(CTSC)
EGZ: 104128838(CTSC)
AAM: 106491260(CTSC)
ASN: 102386282(CTSC)
AMJ: 102576717(CTSC)
PSS: 102453891(CTSC)
CMY: 102935389(CTSC)
CPIC: 101935953(CTSC)
ACS: 100565042(ctsc)
PVT: 110071074(CTSC)
PBI: 103055898(CTSC)
GJA: 107113356(CTSC)
XLA: 108710023(ctsc.S) 380203(ctsc.L)
XTR: 407938(ctsc)
NPR: 108784428(CTSC)
DRE: 368704(ctsc)
IPU: 108278259(ctsc)
AMEX: 103046262(ctsc)
TRU: 101061497(ctsc)
LCO: 104920118(ctsc) 109137152
MZE: 101475307(ctsc)
OLA: 101170449(ctsc)
XMA: 102223206(ctsc)
PRET: 103474488(ctsc)
NFU: 107380452(ctsc)
KMR: 108244622(ctsc)
CSEM: 103378542(ctsc) 103380619
LCF: 108886624(ctsc)
SDU: 111224142(ctsc)
HCQ: 109525508(ctsc)
BPEC: 110174272(ctsc)
MALB: 109971607(ctsc)
SASA: 100196094(catc) 106581413(ctsc) 106613233
ELS: 105024067(ctsc)
SFM: 108932123(ctsc)
LCM: 102365650(CTSC)
CMK: 103184353(ctsc)
SKO: 100378978
CRG: 105339566
MYI: 110449444
SHX: MS3_08498
ADF: 107355896
PYO: PY17X_0933300(PY05365) PY17X_1463300(PY01568)
PCB: PCHAS_091300(PC000818.02.0) PCHAS_146300(PC000458.02.0)
BBO: BBOV_I000540(16.m00694) BBOV_II000170(18.m05995)
CPV: cgd4_2110
SMIN: v1.2.031841.t1(symbB.v1.2.031841.t1)
 » show all
Taxonomy
Reference
1  [PMID:14209333]
  Authors
PLANTA RJ, GORTER J, GRUBER M.
  Title
THE CATALYTIC PROPERTIES OF CATHEPSIN C.
  Journal
Biochim Biophys Acta 89:511-9 (1964)
Reference
2  [PMID:5961281]
  Authors
Metroione RM, Neves AG, Fruton JS.
  Title
Purification and properties of dipeptidyl transferase (Cathepsin C).
  Journal
Biochemistry 5:1597-604 (1966)
Reference
3  [PMID:4306035]
  Authors
McDonald JK, Zeitman BB, Reilly TJ, Ellis S.
  Title
New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.
  Journal
J Biol Chem 244:2693-709 (1969)
Reference
4
  Authors
McDonald, J.K. and Schwabe, C.
  Title
Intracellular exopeptidases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.1
IUBMB Enzyme Nomenclature: 3.4.14.1
ExPASy - ENZYME nomenclature database: 3.4.14.1
BRENDA, the Enzyme Database: 3.4.14.1
CAS: 9032-68-2

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