KEGG   ENZYME: 3.4.14.10Help
Entry
EC 3.4.14.10                Enzyme                                 

Name
tripeptidyl-peptidase II;
tripeptidyl aminopeptidase;
tripeptidyl peptidase;
tripeptidyl aminopeptidase II;
tripeptidyl peptidase II;
TPP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide
Comment
A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8
History
EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)
Orthology
K01280  tripeptidyl-peptidase II
Genes
HSA: 7174(TPP2)
PTR: 452645(TPP2)
PPS: 100979697(TPP2)
GGO: 101135379(TPP2)
PON: 100172493(TPP2)
NLE: 100581612(TPP2) 100592431 105739200
MCC: 701311(TPP2)
MCF: 101865014(TPP2)
CSAB: 103214737(TPP2)
RRO: 104654017(TPP2)
RBB: 108521644(TPP2)
CJC: 100391991(TPP2)
SBQ: 101037381(TPP2)
MMU: 22019(Tpp2)
RNO: 81815(Tpp2)
CGE: 100751018(Tpp2)
NGI: 103751647(Tpp2)
HGL: 101700345(Tpp2)
CCAN: 109693747(Tpp2)
OCU: 100359134(TPP2)
TUP: 102491918(TPP2)
CFA: 100855853(TPP2)
AML: 100472407(TPP2)
UMR: 103657636(TPP2)
ORO: 101371298(TPP2)
FCA: 101082370(TPP2)
PTG: 102969991(TPP2)
AJU: 106983027(TPP2)
BTA: 526052(TPP2)
BOM: 102273977(TPP2)
BIU: 109566938(TPP2)
PHD: 102333369(TPP2)
CHX: 102169112(TPP2)
OAS: 101113507(TPP2)
SSC: 100511152(TPP2)
CFR: 102514630(TPP2)
CDK: 105094097(TPP2)
BACU: 103006667(TPP2)
LVE: 103077108(TPP2)
OOR: 101284092(TPP2)
ECB: 100050973(TPP2)
EPZ: 103560019(TPP2)
EAI: 106830041(TPP2)
MYB: 102261518(TPP2)
MYD: 102763719(TPP2)
HAI: 109394087(TPP2)
RSS: 109439992 109447057(TPP2)
PALE: 102878730(TPP2)
LAV: 100675866(TPP2)
TMU: 101341260
MDO: 100018913(TPP2)
SHR: 100932521(TPP2)
OAA: 100082920(TPP2)
GGA: 428020(TPP2)
MGP: 100540785(TPP2)
CJO: 107307969(TPP2)
APLA: 101800618(TPP2)
ACYG: 106031919(TPP2)
TGU: 100221846(TPP2)
GFR: 102037153(TPP2)
FAB: 101820047(TPP2)
PHI: 102108612(TPP2)
PMAJ: 107207308(TPP2)
CCAE: 111944484(TPP2)
CCW: 104685991(TPP2)
FPG: 101917191(TPP2)
FCH: 102051260(TPP2)
CLV: 102092306(TPP2)
EGZ: 104131382(TPP2)
AAM: 106493913(TPP2)
ASN: 102383303(TPP2)
AMJ: 102568353(TPP2)
PSS: 102443431(TPP2)
CMY: 102932230(TPP2)
CPIC: 101932912(TPP2)
ACS: 100552517(tpp2)
PVT: 110080003(TPP2)
PBI: 103065222(TPP2)
GJA: 107115732(TPP2)
XLA: 108709744(tpp2.S) 443806(tpp2.L)
XTR: 100101674(tpp2)
NPR: 108804747(TPP2)
DRE: 100331669(tpp2)
SRX: 107748328 107751091
SANH: 107665822 107694479 107698925
SGH: 107557266(tpp2) 107574388 107593811
CCAR: 109077374 109081816 109082630 109085586
IPU: 108258999(tpp2)
AMEX: 103046829(tpp2)
TRU: 101077190(tpp2)
TNG: GSTEN00017928G001 GSTEN00034450G001
LCO: 104922536(tpp2)
NCC: 104958875(tpp2)
MZE: 101481116(tpp2)
OLA: 101174009(tpp2)
XMA: 102234712(tpp2)
PRET: 103461961(tpp2)
NFU: 107381138(tpp2)
KMR: 108251528(tpp2)
CSEM: 103378933(tpp2)
LCF: 108888019(tpp2)
SDU: 111238357(tpp2)
HCQ: 109519672(tpp2)
BPEC: 110173024(tpp2)
MALB: 109964275(tpp2)
SASA: 106575025(tpp2) 106575034
OTW: 112240281
ELS: 105020121(tpp2)
SFM: 108938473(tpp2)
LCM: 102350093(TPP2)
CMK: 103177578(tpp2) 103178210
BFO: BRAFLDRAFT_119698 BRAFLDRAFT_119705
CIN: 100177474(tpp2)
SPU: 583848
APLC: 110983628
SKO: 102807403 102808627
DME: Dmel_CG3991(TppII)
DPO: Dpse_GA24414
DAN: Dana_GF11981
DSE: Dsec_GM20311
DSI: Dsimw501_GD25789(Dsim_GD25789)
DYA: Dyak_GE13397
DGR: Dgri_GH21590
DMO: Dmoj_GI19561
DVI: Dvir_GJ21137
MDE: 101889276
AGA: AgaP_AGAP004870
AAG: 5572106
CQU: CpipJ_CPIJ013852
AME: 412055
BIM: 100749640
BTER: 100647107
SOC: 105200904
AEC: 105154625
ACEP: 105622872
PBAR: 105433561
HST: 105185706
DQU: 106745676
CFO: 105251650
LHU: 105674024
PGC: 109854061
NVI: 100122357
MDL: 103568194
TCA: 657622
DPA: 109540902
NVL: 108556611
BMOR: 101742969
DPL: KGM_202963
PMAC: 106716063
PRAP: 111000981 111001663
HAW: 110380302
PXY: 105393364 105395944
API: 100159456 100161895
DNX: 107165447
CLEC: 106660826
PHU: Phum_PHUM454920
ZNE: 110835281
FCD: 110856131
DPX: DAPPUDRAFT_186919
ISC: IscW_ISCW006099
TUT: 107366136
CEL: CELE_F21H12.6(tpp-2)
CBR: CBG02572
NAI: NECAME_01499
BMY: Bm1_25090
LOA: LOAG_08100
TSP: Tsp_09238
HRO: HELRODRAFT_107485
LGI: LOTGIDRAFT_129137
CRG: 105320486
MYI: 110462454
OBI: 106874742
LAK: 106161240 106179437
SMM: Smp_131220
SHX: MS3_00195
OVI: T265_15389
EGL: EGR_08923
NVE: NEMVE_v1g176183
EPA: 110246127
ADF: 107332456
HMG: 100205895
TAD: TRIADDRAFT_61672
AQU: 100631430 105316109 109589028
ATH: AT4G20850(TPP2)
ALY: ARALYDRAFT_492801
CRB: 17879953
CSAT: 104718255 104722978 104733446 109124484
EUS: EUTSA_v10024222mg
BRP: 103858419 103861204
BNA: 106358188 106375690 106421156 106438545
BOE: 106303335 106307134
THJ: 104812206 104824854 104824860
CPAP: 110810280
CIT: 102615091
CIC: CICLE_v10004167mg
TCC: 18605576
GRA: 105791164 105801784
GHI: 107904614 107917752 107923906 107923907 107952372
DZI: 111281175 111289774
EGR: 104448732 108954417
GMX: 100777892 100787184 100798235 102663765
PVU: PHAVU_004G114200g PHAVU_007G071600g
VRA: 106770186 106771922
VAR: 108326206 108345579
CCAJ: 109803113 109819233
MTR: MTR_0025s0060 MTR_1g101030
CAM: 101490818 101494371 101503191 101512687
LJA: Lj0g3v0190979.1(Lj0g3v0190979.1) Lj2g3v0391790.1(Lj2g3v0391790.1) Lj5g3v2013440.1(Lj5g3v2013440.1)
ADU: 107466965 107491142
AIP: 107617711 107623769 107644848 107648243
LANG: 109335589 109354856
FVE: 101291383
PPER: 18787294
PMUM: 103333208
PAVI: 110767759
MDM: 103437392 103437393 103439777
PXB: 103932208 103934922
ZJU: 107414512
CSV: 101220162(TPP2)
CMO: 103482548
MCHA: 111025404
CMAX: 111471490
CMOS: 111430230
CPEP: 111808490
RCU: 8281007
JCU: 105648461
HBR: 110662206
POP: 7474052 7482079
JRE: 108996808 108998580
VVI: 100248019(TPP2)
SLY: 101244555
SPEN: 107013102 107013676 107013677
SOT: 102591471
CANN: 107863279
NTA: 107784804 107798947 107817970
NSY: 104243251
NTO: 104109952
INI: 109146488
SIND: 105160468
OEU: 111402996 111404219
HAN: 110885815
LSV: 111900783
CCAV: 112526125
DCR: 108203289
BVG: 104888547
SOE: 110784171
NNU: 104596074
OSA: 4330237
DOSA: Os02t0664300-01(Os02g0664300)
OBR: 102701235
BDI: 100840642
ATS: 109732424(LOC109732424)
SBI: 8076065
ZMA: 103627523
SITA: 101765055
PDA: 103719383
EGU: 105042882
MUS: 103970347
DCT: 110099325
AOF: 109837263
ATR: 18423030
SMO: SELMODRAFT_144433 SELMODRAFT_74857
PPP: 112278876 112284251
CRE: CHLREDRAFT_174517
VCN: VOLCADRAFT_93498
MNG: MNEG_9542
CSL: COCSUDRAFT_27430
CVR: CHLNCDRAFT_58768
APRO: F751_2683
CCP: CHC_T00004817001
SPO: SPAP8A3.12c(tpp2)
UMA: UMAG_12106
PFP: PFL1_06234
MGL: MGL_0154
MBR: MONBRDRAFT_34612
SRE: PTSG_10288
ACAN: ACA1_149240
PTI: PHATRDRAFT_26948
FCY: FRACYDRAFT_262448
AAF: AURANDRAFT_18489 AURANDRAFT_62802
PIF: PITG_04457
PSOJ: PHYSODRAFT_565047
SPAR: SPRG_02495 SPRG_22108
EHX: EMIHUDRAFT_121183 EMIHUDRAFT_447922 EMIHUDRAFT_454415
GTT: GUITHDRAFT_99926
NGR: NAEGRDRAFT_78168
PBS: Plabr_2899
 » show all
Taxonomy
Reference
1  [PMID:6352701]
  Authors
Balow RM, Ragnarsson U, Zetterqvist O.
  Title
Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver.
  Journal
J Biol Chem 258:11622-8 (1983)
Reference
2  [PMID:3511062]
  Authors
Balow RM, Tomkinson B, Ragnarsson U, Zetterqvist O.
  Title
Purification, substrate specificity, and classification of tripeptidyl peptidase II.
  Journal
J Biol Chem 261:2409-17 (1986)
Reference
3  [PMID:1691635]
  Authors
Tomkinson B, Zetterqvist O.
  Title
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
  Journal
Biochem J 267:149-54 (1990)
  Sequence
[hsa:7174]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.10
IUBMB Enzyme Nomenclature: 3.4.14.10
ExPASy - ENZYME nomenclature database: 3.4.14.10
BRENDA, the Enzyme Database: 3.4.14.10
CAS: 101149-94-4

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