KEGG   ENZYME: 3.4.14.4Help
Entry
EC 3.4.14.4                 Enzyme                                 

Name
dipeptidyl-peptidase III;
dipeptidyl aminopeptidase III;
dipeptidyl arylamidase III;
enkephalinase B;
red cell angiotensinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Comment
A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49.
History
EC 3.4.14.4 created 1981, modified 2001
Orthology
K01277  dipeptidyl-peptidase III
Genes
HSA: 10072(DPP3)
PTR: 100613456(DPP3)
PPS: 100971539(DPP3)
GGO: 101128992(DPP3)
PON: 100172221(DPP3)
NLE: 100595091(DPP3)
MCC: 721809(DPP3)
MCF: 102131147(DPP3)
CSAB: 103222490(DPP3) 103228650
RRO: 104664772(DPP3)
RBB: 108518602(DPP3)
CJC: 100393210(DPP3)
SBQ: 101027916(DPP3)
MMU: 75221(Dpp3)
RNO: 114591(Dpp3)
CGE: 100760621(Dpp3)
NGI: 103725034(Dpp3)
HGL: 101721371(Dpp3)
CCAN: 109687068(Dpp3)
OCU: 100358846(DPP3)
TUP: 102493027(DPP3)
CFA: 476011(DPP3)
AML: 100484390(DPP3)
UMR: 103679495(DPP3)
ORO: 101367015(DPP3)
FCA: 101099587(DPP3)
PTG: 102962861(DPP3)
AJU: 106971200(DPP3)
BTA: 510200(DPP3)
BOM: 102280041(DPP3)
BIU: 109554468(DPP3)
PHD: 102327512(DPP3)
CHX: 102177139(DPP3)
OAS: 101115241(DPP3)
SSC: 100519350(DPP3)
CFR: 102506535(DPP3)
CDK: 105104457(DPP3)
BACU: 103009087(DPP3)
LVE: 103074526(DPP3)
OOR: 101277035(DPP3)
ECB: 100058485(DPP3)
EPZ: 103559636(DPP3)
EAI: 106833526(DPP3)
MYB: 102240410(DPP3)
MYD: 102753158(DPP3)
HAI: 109384257(DPP3)
RSS: 109450458(DPP3)
PALE: 102898581(DPP3)
LAV: 100677496(DPP3)
TMU: 101352046
MDO: 100619774(DPP3)
SHR: 100928407(DPP3)
OAA: 103167151(DPP3)
PSS: 102460456(DPP3)
CMY: 102939340(DPP3)
CPIC: 101933103(DPP3)
ACS: 100562322(dpp3)
PVT: 110069797(DPP3)
PBI: 103049733(DPP3)
GJA: 107115216(DPP3)
XLA: 394413(dpp3.S) 446491(dpp3.L)
XTR: 101732710(dpp3)
NPR: 108784144(DPP3)
DRE: 322527(dpp3)
IPU: 108278869(dpp3)
AMEX: 103042368(dpp3)
TRU: 101074134(dpp3)
LCO: 104935082(dpp3)
NCC: 104966988(dpp3)
MZE: 101469827(dpp3)
OLA: 101174283(dpp3)
XMA: 102225547(dpp3)
PRET: 103475408(dpp3)
NFU: 107386740(dpp3)
KMR: 108238973(dpp3)
CSEM: 103395536(dpp3)
LCF: 108893201(dpp3)
SDU: 111217164(dpp3)
HCQ: 109512419(dpp3)
BPEC: 110155883(dpp3)
MALB: 109959949(dpp3)
SASA: 100195375(dpp3) 106602977
OTW: 112228944 112231170(dpp3)
ELS: 105030038(dpp3)
SFM: 108934058(dpp3)
LCM: 102362934(DPP3)
CMK: 103173566(dpp3)
SPU: 582874
APLC: 110979282
SKO: 100367734
DME: Dmel_CG7415(DppIII)
DSI: Dsimw501_GD18539(Dsim_GD18539)
MDE: 101892395
AAG: 5576366
AME: 412232
BIM: 100747855
BTER: 100644845
SOC: 105203676
AEC: 105147695
ACEP: 105620272
PBAR: 105432035
HST: 105188320
DQU: 106751823
CFO: 105258241
LHU: 105677201
PGC: 109853134
PCF: 106787582
NVI: 100117644
MDL: 103572895
TCA: 661730
DPA: 109534100
NVL: 108566561
BMOR: 101739960
PRAP: 110995888
HAW: 110384066
ZNE: 110837876
FCD: 110859164
CEL: CELE_F02E9.9(dpt-1)
CBR: CBG12727
CRG: 105348163
MYI: 110466501
LAK: 106165474
SHX: MS3_08945
EGL: EGR_02960
EPA: 110231277
PPP: 112286215
SCE: YOL057W
ERC: Ecym_5245
NCS: NCAS_0C03640(NCAS0C03640)
TPF: TPHA_0P00610(TPHA0P00610)
TDL: TDEL_0D04520(TDEL0D04520)
KAF: KAFR_0C00980(KAFR0C00980)
PIC: PICST_88224(DPP3)
CAL: CAALFM_C603960WA(CaO19.5773)
CAUR: QG37_04885
NCR: NCU02701
NTE: NEUTE1DRAFT126368(NEUTE1DRAFT_126368)
SSCK: SPSK_08655
MBE: MBM_05956
ANI: AN4321.2
ANG: ANI_1_170184(An04g00410)
ABE: ARB_02670
TVE: TRV_05416
ABP: AGABI1DRAFT118131(AGABI1DRAFT_118131)
ABV: AGABI2DRAFT64000(AGABI2DRAFT_64000)
DDI: DDB_G0273471(dpp3-1) DDB_G0273563(dpp3-2)
DFA: DFA_05541
EHI: EHI_110750(58.t00023)
OTE: Oter_3045
SACI: Sinac_4683
SUS: Acid_0377
BTH: BT_1846
BFR: BF3425
BVU: BVU_2015
BXY: BXY_14930
BACC: BRDCF_p710
PGI: PG_0317
PGN: PGN_1645
PMUC: ING2E5A_1809(dpp3-1)
PDI: BDI_3779
TFO: BFO_1524
PSAC: PSM36_2003
APS: CFPG_728
PRU: PRU_0989
AFD: Alfi_2483
ASH: AL1_29480
MBAS: ALGA_0376
HSW: Hsw_2933
GFO: GFO_0057
DDO: I597_2396
NDO: DDD_3018
MPW: MPR_2908
WIN: WPG_0345
TMAR: MARIT_0621
MARF: CJ739_2793
FBU: UJ101_02005(DPP3)
MRO: MROS_1275
 » show all
Taxonomy
Reference
1
  Authors
McDonald, J.K.
  Title
Dipeptidyl-peptidase III.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 536-538.
Reference
2  [PMID:10387075]
  Authors
Fukasawa K, Fukasawa KM, Iwamoto H, Hirose J, Harada M.
  Title
The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme.
  Journal
Biochemistry 38:8299-303 (1999)
DOI:10.1021/bi9904959
  Sequence
[rno:114591]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.4
IUBMB Enzyme Nomenclature: 3.4.14.4
ExPASy - ENZYME nomenclature database: 3.4.14.4
BRENDA, the Enzyme Database: 3.4.14.4
CAS: 77464-87-0

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