| Entry |
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| Name |
dipeptidyl-peptidase IV;
dipeptidyl aminopeptidase IV;
Xaa-Pro-dipeptidyl-aminopeptidase;
Gly-Pro naphthylamidase;
postproline dipeptidyl aminopeptidase IV;
lymphocyte antigen CD26;
glycoprotein GP110;
dipeptidyl peptidase IV;
glycylproline aminopeptidase;
glycylproline aminopeptidase;
X-prolyl dipeptidyl aminopeptidase;
pep X;
leukocyte antigen CD26;
glycylprolyl dipeptidylaminopeptidase;
dipeptidyl-peptide hydrolase;
glycylprolyl aminopeptidase;
dipeptidyl-aminopeptidase IV;
DPP IV/CD26;
amino acyl-prolyl dipeptidyl aminopeptidase;
T cell triggering molecule Tp103;
X-PDAP
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
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| Reaction(IUBMB) |
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
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| Comment |
A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci
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| History |
EC 3.4.14.5 created 1981, modified 1996
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Misumi Y, Hayashi Y, Arakawa F, Ikehara Y. |
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| Title |
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
David F, Bernard AM, Pierres M, Marguet D. |
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| Title |
Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases. |
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| Journal |
J Biol Chem 268:17247-52 (1993) |
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| Reference |
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| Authors |
Ikehara Y, Ogata S, Misumi Y. |
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| Title |
Dipeptidyl-peptidase IV from rat liver. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.14.5 |
| ExPASy - ENZYME nomenclature database: | 3.4.14.5 |
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