KEGG   ENZYME: 3.4.14.9Help
Entry
EC 3.4.14.9                 Enzyme                                 

Name
tripeptidyl-peptidase I;
tripeptidyl aminopeptidase;
tripeptidyl peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
Comment
A lysosomal enzyme that is active at acidic pH. Deficient in classical late-infantile neuronal ceroid lipofuscinosis brain tissue. Belongs in peptidase family S53. Formerly included in EC 3.4.14.8.
History
EC 3.4.14.9 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992), modified 2000, modified 2001, modified 2003
Orthology
K01279  tripeptidyl-peptidase I
Genes
HSA: 1200(TPP1)
PTR: 450999(TPP1)
PPS: 100969179(TPP1)
GGO: 101149790(TPP1)
PON: 100440001(TPP1)
NLE: 100586648(TPP1)
MCC: 709838(TPP1)
MCF: 101867272(TPP1)
CSAB: 103241292(TPP1)
RRO: 104678305(TPP1)
RBB: 108543236(TPP1)
CJC: 100895900(TPP1)
SBQ: 101030033(TPP1)
MMU: 12751(Tpp1)
RNO: 83534(Tpp1)
CGE: 100759190(Tpp1)
NGI: 103737566(Tpp1)
HGL: 101707185(Tpp1)
CCAN: 109696314(Tpp1)
OCU: 100356773(TPP1)
TUP: 102474485(TPP1)
CFA: 485337(TPP1)
AML: 100473391(TPP1)
UMR: 103681402(TPP1)
ORO: 101364552(TPP1)
FCA: 101093296(TPP1) 111559084
PTG: 102968271(TPP1)
AJU: 106981175(TPP1)
BTA: 515575(TPP1)
BOM: 102279785(TPP1)
BIU: 109569865(TPP1)
PHD: 102332223(TPP1)
CHX: 102176981(TPP1)
OAS: 101116858(TPP1)
SSC: 100623352(TPP1)
CFR: 102512212(TPP1)
CDK: 105097984(TPP1)
BACU: 103017792(TPP1)
LVE: 103084335(TPP1)
OOR: 101288758(TPP1)
ECB: 100070095(TPP1)
EPZ: 103553536(TPP1)
EAI: 106838179(TPP1)
MYB: 102249131(TPP1)
MYD: 102763994(TPP1)
HAI: 109376530(TPP1)
RSS: 109460450(TPP1)
PALE: 102887010(TPP1)
LAV: 100666542(TPP1)
TMU: 101346186
MDO: 100030970(TPP1)
SHR: 100918462(TPP1)
OAA: 100682200
GGA: 425576(TPP1)
MGP: 104916731(TPP1)
CJO: 107308570(TPP1)
APLA: 101792345(TPP1)
ACYG: 106049774(TPP1)
TGU: 100232321(TPP1)
GFR: 102035657(TPP1)
FAB: 101810332(TPP1)
PHI: 102114063(TPP1)
PMAJ: 107198426(TPP1)
CCAE: 111943727(TPP1)
CCW: 104698105(TPP1)
FPG: 101920803(TPP1)
FCH: 102051334(TPP1)
CLV: 102094093
EGZ: 104130616(TPP1)
ASN: 102377067(TPP1)
AMJ: 102560569(TPP1)
PSS: 102443613(TPP1) 102459935
CMY: 102933063(TPP1)
CPIC: 101951787(TPP1)
ACS: 100556940(tpp1)
PVT: 110078112(TPP1)
PBI: 103059366(TPP1)
GJA: 107116951(TPP1)
XLA: 414505(tpp1.L)
XTR: 100124868(tpp1)
NPR: 108799885(TPP1)
DRE: 798347(tpp1)
SGH: 107594810
IPU: 108270113(tpp1)
AMEX: 103045803(tpp1)
TRU: 101071259(tpp1)
LCO: 104921573(tpp1) 109142670
NCC: 104960361(tpp1)
MZE: 101481977(tpp1)
OLA: 101174237(tpp1)
XMA: 102217421(tpp1)
PRET: 103458893(tpp1)
NFU: 107392300(tpp1)
KMR: 108236790(tpp1)
CSEM: 103376880(tpp1)
SDU: 111225389(tpp1)
HCQ: 109526111(tpp1)
BPEC: 110155486(tpp1)
SASA: 100195058(tpp1)
OTW: 112256401(tpp1)
ELS: 105015977(tpp1)
SFM: 108941423(tpp1)
LCM: 102367029(TPP1)
CMK: 103185353(tpp1)
EPA: 110249513
ADF: 107356232
HMG: 100213935
NCR: NCU08418
NTE: NEUTE1DRAFT108290(NEUTE1DRAFT_108290) NEUTE1DRAFT64480(NEUTE1DRAFT_64480)
ANG: ANI_1_10054(An06g00190) ANI_1_1008034(An03g01010) ANI_1_1554144(An16g02250) ANI_1_1628094(An11g01110) ANI_1_218014(An01g01750) ANI_1_368124(An14g02470) ANI_1_676074(An08g04640)
ABP: AGABI1DRAFT72616(AGABI1DRAFT_72616) AGABI1DRAFT83390(AGABI1DRAFT_83390)
ABV: AGABI2DRAFT193429(AGABI2DRAFT_193429) AGABI2DRAFT195772(AGABI2DRAFT_195772)
DDI: DDB_G0269914(tpp1)
SMIN: v1.2.016800.t1(symbB.v1.2.016800.t1) v1.2.026734.t1(symbB.v1.2.026734.t1)
NGD: NGA_0706700(TPP1)
 » show all
Taxonomy
Reference
1  [PMID:10349869]
  Authors
Ezaki J, Tanida I, Kanehagi N, Kominami E.
  Title
A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.
  Journal
J Neurochem 72:2573-82 (1999)
DOI:10.1046/j.1471-4159.1999.0722573.x
Reference
2  [PMID:9989235]
  Authors
Rawlings ND, Barrett AJ.
  Title
Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis.
  Journal
Biochim Biophys Acta 1429:496-500 (1999)
DOI:10.1016/S0167-4838(98)00238-6
Reference
3  [PMID:10679303]
  Authors
Ezaki J, Takeda-Ezaki M, Oda K, Kominami E.
  Title
Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis.
  Journal
Biochem Biophys Res Commun 268:904-8 (2000)
DOI:10.1006/bbrc.2000.2207
  Sequence
[rno:83534]
Reference
4  [PMID:10617131]
  Authors
Junaid MA, Wu G, Pullarkat RK.
  Title
Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis.
  Journal
J Neurochem 74:287-94 (2000)
DOI:10.1046/j.1471-4159.2000.0740287.x
  Sequence
[bta:515575]
Reference
5  [PMID:11054422]
  Authors
Lin L, Sohar I, Lackland H, Lobel P.
  Title
The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH.
  Journal
J Biol Chem 276:2249-55 (2001)
DOI:10.1074/jbc.M008562200
  Sequence
[hsa:1200]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.9
IUBMB Enzyme Nomenclature: 3.4.14.9
ExPASy - ENZYME nomenclature database: 3.4.14.9
BRENDA, the Enzyme Database: 3.4.14.9
CAS: 151662-36-1

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