KEGG   ENZYME: 3.4.15.5Help
Entry
EC 3.4.15.5                 Enzyme                                 

Name
peptidyl-dipeptidase Dcp;
dipeptidyl carboxypeptidase (Dcp);
dipeptidyl carboxypeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Peptidyl-dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly
Comment
Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala!Ala-Ala is a good test substrate [3]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC 3.4.15.3, and included in EC 3.4.15.1, peptidyl-dipeptidase A.
History
EC 3.4.15.5 created 1981 as EC 3.4.15.3, modified 1989, transferred 1996 to EC 3.4.15.5
Orthology
K01284  peptidyl-dipeptidase Dcp
Genes
LMA: LMJF_02_0740(DCP) LMJF_27_2660
LIF: LINJ_02_0710(DCP) LINJ_22_1540
LDO: LDBPK_020710
LMI: LMXM_01_0830 LMXM_02_0740
LBZ: LBRM_02_0670 LBRM_27_1640 LBRM_27_1650 LBRM_27_2760 LBRM_27_2780
ECO: b1538(dcp)
ECJ: JW1531(dcp)
ECD: ECDH10B_1669(dcp)
EBW: BWG_1358(dcp)
ECOK: ECMDS42_1249(dcp)
ECE: Z2160(dcp)
ECS: ECs2147
ECF: ECH74115_2154(dcp)
ETW: ECSP_2025(dcp)
EOJ: ECO26_2149(dcp)
EOI: ECO111_1941(dcp)
EOH: ECO103_1676(dcp)
ECOO: ECRM13514_1852(dcp)
ECOH: ECRM13516_1904(dcp)
ECG: E2348C_1658(dcp)
EOK: G2583_1905(dcp)
ESO: O3O_12885
ESM: O3M_12710
ESL: O3K_12750
ECW: EcE24377A_1747(dcp)
ELH: ETEC_1608
ECC: c1964(dcp)
ECP: ECP_1522
ECI: UTI89_C1761(dcp)
ECV: APECO1_659(dcp)
ECX: EcHS_A1628(dcp)
ECM: EcSMS35_1627(dcp)
ECY: ECSE_1634
ECR: ECIAI1_1557(dcp)
ECQ: ECED1_1666(dcp)
ECK: EC55989_1679(dcp)
ECT: ECIAI39_1841(dcp)
EOC: CE10_1774(dcp)
EUM: ECUMN_1805(dcp)
ECZ: ECS88_1618(dcp)
ELO: EC042_1670(dcp)
ESE: ECSF_1433
EBR: ECB_01497(dcp)
EBD: ECBD_2101
EAB: ECABU_c17690(dcp)
EDJ: ECDH1ME8569_1481(dcp)
ELW: ECW_m1674(dcp)
ELL: WFL_08200(dcp)
ELC: i14_1787(dcp)
ELD: i02_1787(dcp)
EBL: ECD_01497(dcp)
EBE: B21_01508(dcp)
ELF: LF82_0445(dcp)
ECOI: ECOPMV1_01669(dcp)
ECOJ: P423_08435
ECOS: EC958_1792
EFE: EFER_1537(dcp)
EAL: EAKF1_ch4500(dcp)
STY: STY1549(dcp)
STT: t1433(dcp)
STM: STM1512(dcp)
SEO: STM14_1826(dcp)
SEY: SL1344_1442(dcp)
SEJ: STMUK_1476(dcp)
SEB: STM474_1523(dcp)
SEF: UMN798_1577(dcp)
SENR: STMDT2_14391(dcp)
SEND: DT104_14821(dcp)
SENI: CY43_07700
SPT: SPA1343(dcp)
SEK: SSPA1248
SEI: SPC_2217(dcp)
SEC: SCH_1529(dcp)
SHB: SU5_02122
SENS: Q786_07685
SED: SeD_A1825
SEG: SG1607(dcp)
SEL: SPUL_1329(dcp)
SEGA: SPUCDC_1329(dcp)
SET: SEN1539(dcp)
SENA: AU38_07950
SENO: AU37_07950
SENV: AU39_07960
SENQ: AU40_08905
SENL: IY59_08145
SEEP: I137_06155
SENE: IA1_07480
SBG: SBG_1339(dcp)
SBZ: A464_1533
SFL: SF1557(dcp)
SFX: S1682(dcp)
SFV: SFV_1552(dcp)
SFE: SFxv_1745(dcp)
SFN: SFy_2234
SFS: SFyv_2287
SFT: NCTC1_01686(dcp)
SSN: SSON_1590(dcp)
SBO: SBO_1612(dcp)
SBC: SbBS512_E1702(dcp)
SDY: SDY_1587(dcp)
ENC: ECL_02170
ECLO: ENC_11960
EEC: EcWSU1_02024(dcp)
ECLX: LI66_10125
ECLY: LI62_10920
ECLZ: LI64_10275
ESA: ESA_01759
CSK: ES15_1941(dcp)
CTU: CTU_21940(dcp)
KPN: KPN_01591(dcp)
KPU: KP1_2614(dcp)
KPP: A79E_2645
KPE: KPK_2864(dcp)
KPR: KPR_2474(dcp)
KPJ: N559_2732
KPX: PMK1_03910(dcp)
KPNU: LI86_13635
KPNK: BN49_2701(dcp)
KVA: Kvar_2766
KOX: KOX_21485
KOE: A225_3166
EAE: EAE_18455
CKO: CKO_01568
CRO: ROD_14891(dcp)
CAMA: F384_06850
EBT: EBL_c21580(dcp)
EBF: D782_2215
YRU: BD65_95
SPE: Spro_2306
SRL: SOD_c21360(dcp)
SPLY: Q5A_011835(dcp)
SMAF: D781_2347
SMW: SMWW4_v1c23200(dcp)
SMAR: SM39_1765(dcp)
SMAC: SMDB11_1576(dcp)
SERF: L085_17145
RAA: Q7S_00720
SOD: Sant_1990
ETA: ETA_17490(dcp)
EPY: EpC_18400(dcp)
EPR: EPYR_01982(dcp)
EAM: EAMY_1749(dcp)
EAY: EAM_1717(dcp)
EBI: EbC_22700(dcp)
ERJ: EJP617_28850(dcp)
EGE: EM595_1761(dcp)
PAM: PANA_1961(dcp)
PLF: PANA5342_2218(dcp)
PAJ: PAJ_1293(dcp)
PVA: Pvag_1368(dcp)
PSTW: DSJ_14015
XNE: XNC1_0616(dcp)
XNM: XNC2_0604(dcp)
XFA: XF_1944
XFT: PD_0856(dcp)
XCC: XCC0230(dcp) XCC1412(dcp)
XCA: xcc-b100_0252(dcp1) xcc-b100_2886(dcp2)
XCV: XCV0255(dcp2) XCV1513(dcp)
XAX: XACM_0235(dcp2) XACM_1445(dcp)
XAC: XAC0249(dcp) XAC1456(dcp)
XCI: XCAW_00648(dcp) XCAW_02887(dcp)
XOO: XOO0344(dcp)
XOM: XOO0316(XOO0316) XOO2220(XOO2220) XOO2221(XOO2221)
XAL: XALC_3061(dcp)
XPH: XppCFBP6546_04060(XppCFBP6546P_04060) XppCFBP6546_10660(XppCFBP6546P_10660)
SML: Smlt0223(dcp) Smlt3229
SMZ: SMD_0192(dcp) SMD_2806
PSUW: WQ53_00435
PSD: DSC_07770
LEZ: GLE_3090(dcp)
LEM: LEN_1954
DKO: I596_2921
SON: SO_3142(dcp) SO_3564(dcp)
SWD: Swoo_1927
SVO: SVI_2622(dcp)
ILO: IL1691(dcp)
CPS: CPS_4267(dcp)
PHA: PSHAa2184(dcp)
PSM: PSM_A0953(dcp)
PTN: PTRA_a2641(dcp)
PEA: PESP_a1130(dcp)
PSPO: PSPO_b0075(dcp) PSPO_b0193(dcp)
PART: PARC_a2910(dcp)
PTU: PTUN_a0513(dcp) PTUN_a1211(dcp)
PNG: PNIG_a2837(dcp)
PTD: PTET_a1080(dcp)
PSEN: PNC201_14225(dcp1) PNC201_20070(dcp2)
AMAL: I607_02065
AMAE: I876_02245
AMAO: I634_02310
AMAD: I636_02115
AMAI: I635_02100
AMAG: I533_02020
AAUS: EP12_02125
GNI: GNIT_0383(dcp)
GPS: C427_0412(dcp)
SAGA: M5M_18295
MICC: AUP74_02778(dcp)
KKO: Kkor_1595
KGE: TQ33_0854
DNO: DNO_1351(dcpA) DNO_1352(dcpB)
PSPI: PS2015_953
CVI: CV_3380(dcp1) CV_3381(dcp2)
RFR: Rfer_1048
LIM: L103DPR2_01740(dcp)
JAG: GJA_97 GJA_98(dcp)
CFU: CFU_0175(dcp) CFU_4433(dcp2)
RGE: RGE_21500(dcp)
PBH: AAW51_3574(dcp)
ADE: Adeh_3108
MXA: MXAN_2286(dcp)
CCX: COCOR_01768(dcp)
SUR: STAUR_2075(dcp)
BBA: Bd3171(dcp)
BBAT: Bdt_3098(dcp)
BBW: BDW_11645
BBAC: EP01_01150
BEX: A11Q_2001
BMX: BMS_3024(dcp)
MLO: mlr4139
MES: Meso_0127
AMIH: CO731_01182(dcp)
SME: SMc04403(dcp)
SMX: SM11_chr3431(dcp)
SMI: BN406_03104(dcp)
SMEL: SM2011_c04403(dcp)
SMER: DU99_17815
SMD: Smed_3177
SFD: USDA257_c58230(dcp)
SAME: SAMCFNEI73_Ch3693(dcp)
EAD: OV14_0836
ATU: Atu2664(dcp)
ARA: Arad_4371(dcp)
ATF: Ach5_25490(dcp)
AVI: Avi_4158(dcp)
AGR: AGROH133_08902(dcp)
RET: RHE_CH03916(dcp)
REL: REMIM1_CH04009(dcp)
REP: IE4803_CH04301(dcp)
REI: IE4771_CH04243(dcp)
RLE: RL4507(dcp)
RLG: Rleg_4032
RIR: BN877_I2748(dcp)
RHL: LPU83_3949(dcp)
RGA: RGR602_CH03836(dcp)
RHN: AMJ98_CH04145(dcp)
RPHA: AMC79_CH04134(dcp)
RHT: NT26_3517(dcp)
RHX: AMK02_CH04043(dcp)
RHK: Kim5_CH04276(dcp)
SHZ: shn_19465
BME: BMEII0416
BMEL: DK63_2822
BMEE: DK62_2576
BMF: BAB2_0358(dcp)
BMB: BruAb2_0354(dcp)
BABO: DK55_2349
BABR: DO74_2769
BABT: DK49_2883
BABB: DK48_2342
BABU: DK53_2359
BABS: DK51_2938
BABC: DO78_2701
BMS: BRA0878(dcp)
BSI: BS1330_II0871(dcp)
BSF: BSS2_II0832(dcp)
BSZ: DK67_2831
BSV: BSVBI22_B0870(dcp)
BOV: BOV_A0823(dcp)
BOL: BCOUA_II0878(dcp)
BCAR: DK60_2568
BCAS: DA85_14670
BMR: BMI_II872(dcp)
BPP: BPI_II934(dcp)
BPV: DK65_2772
BVL: BF3285c2_0401(dcp)
OAN: Oant_3302
OAH: DR92_3186
BJA: bll7756(dcp)
BRA: BRADO6258(dcp)
BBT: BBta_1351(dcp)
BRS: S23_63230(dcp)
AOL: S58_64280
BRAD: BF49_3184
BRO: BRAD285_6202(dcp)
RPA: RPA0872
RPB: RPB_4545
RPC: RPC_4839
RPD: RPD_0858
RPE: RPE_4804
RPT: Rpal_0940
NWI: Nwi_0926
NHA: Nham_3417
OCA: OCAR_4921
OCG: OCA5_c30360(dcp)
OCO: OCA4_c29840(dcp)
VGO: GJW-30_1_02476(dcp)
BHE: BH01720(dcp)
BHN: PRJBM_00181(dcp)
BHS: BM1374165_00180(dcp)
BQR: RM11_0151
BTR: BT_0189(dcp)
BTX: BM1374166_00169(dcp)
BGR: Bgr_01810(dcp)
BCD: BARCL_1098(dcp)
BAUS: BAnh1_02990(dcp)
BVN: BVwin_01520(dcp)
BANC: PU02_1319
MEX: Mext_0413
MEA: Mex_1p0328(dcp)
MDI: METDI0482(dcp)
MCH: Mchl_0446
MPO: Mpop_0483
MET: M446_0011
MNO: Mnod_0016
MOR: MOC_3300(dcp)
META: Y590_01560
MAQU: Maq22A_c10480(dcp)
BID: Bind_3258
MSL: Msil_3687
HDN: Hden_3255
HMC: HYPMC_4578(dcp)
RVA: Rvan_2580
BVR: BVIR_3157
MSC: BN69_1319
MMED: Mame_00779(dcp)
CCR: CC_3702
CSE: Cseg_4211
PZU: PHZ_c0120(dcp)
SIL: SPO0414
RSP: RSP_0596
RCP: RCAP_rcc00521(dcp)
JAN: Jann_0912
RDE: RD1_1203(dcp)
RLI: RLO149_c035770(dcp)
PDE: Pden_1944
DSH: Dshi_2973(dcp)
KVU: EIO_0247
KVL: KVU_2588(dcp)
KRO: BVG79_00268(dcp)
PSF: PSE_3524(dcp)
PGA: PGA1_c26590(dcp)
PGL: PGA2_c24620(dcp)
PGD: Gal_00771
PHP: PhaeoP97_02602(dcp)
PPIC: PhaeoP14_02404(dcp)
OAT: OAN307_c38870(dcp)
OTM: OSB_05290(dcp)
PTP: RCA23_c21270(dcp)
CID: P73_3820
MALG: MALG_03037
RSU: NHU_03232(dcp)
RHC: RGUI_3119
SPSE: SULPSESMR1_00064(dcp)
RMM: ROSMUCSMR3_01242(dcp)
AHT: ANTHELSMS3_01624(dcp)
HNE: HNE_3288(dcp)
SAL: Sala_3161
SPHP: LH20_01075
SMAZ: LH19_00470
SGI: SGRAN_3698(dcp)
SPHU: SPPYR_3180
SPHI: TS85_00875
SSAN: NX02_27795
SSY: SLG_05650(dcp)
SFLA: SPHFLASMR4Y_01810(dcp)
BLAS: BSY18_2161
ELI: ELI_07930
GOX: GOX2134
GOH: B932_2856
GOY: GLS_c22410(dcp)
GDI: GDI2583(dcp)
GDJ: Gdia_0817
ASZ: ASN_2654(dcp)
RCE: RC1_2186(dcp)
ABS: AZOBR_p220087(dcp)
CGL: NCgl2219(Cgl2301)
CGB: cg2527(dcp)
CGU: WA5_2219(Dcp)
CGT: cgR_2173
CGM: cgp_2527(dcp)
CGJ: AR0_11005
CEF: CE2203
CDI: DIP1728
CDP: CD241_1661(dcp)
CDH: CDB402_1619(dcp)
CDT: CDHC01_1664(dcp)
CDE: CDHC02_1598(dcp)
CDR: CDHC03_1627(dcp)
CDA: CDHC04_1625(dcp)
CDZ: CD31A_1734(dcp)
CDB: CDBH8_1701(dcp)
CDS: CDC7B_1713(dcp)
CDD: CDCE8392_1625(dcp)
CDW: CDPW8_1720(dcp)
CDV: CDVA01_1589(dcp)
CDIP: ERS451417_01745(dcp)
CJK: jk0594(dcp)
CUR: cu1341
CUA: CU7111_1322(dcp)
CAR: cauri_0524(dcp)
CPU: cpfrc_01543(dcp)
CPL: Cp3995_1579(dcp)
CPP: CpP54B96_1564(dcp)
CPK: Cp1002_1534(dcp)
CPQ: CpC231_1537(dcp)
CPX: CpI19_1543(dcp)
CPZ: CpPAT10_1537(dcp)
COR: Cp267_1601(dcp)
COP: Cp31_1534(dcp)
COD: Cp106_1499(dcp)
COS: Cp4202_1527(dcp)
COI: CpCIP5297_1549(dcp)
COE: Cp258_1543(dcp)
COU: Cp162_1514(dcp)
CPSE: CPTA_02130
CPSU: CPTB_01629
CPSF: CPTC_02129
CRD: CRES_0671(dcp)
CUL: CULC22_01637(dcp)
CUC: CULC809_01620(dcp)
CUE: CULC0102_1756(dcp)
CUN: Cul210932_1714(dcp)
CUS: CulFRC11_1614(dcp)
CUQ: Cul210931_1611(dcp)
CUZ: Cul05146_1698(dcp)
CUJ: CUL131002_1636c(dcp)
CVA: CVAR_1051(dcp)
CTER: A606_04110
COA: DR71_429
CSX: CSING_02915(dcp)
CKU: UL82_03650(dcp)
CMV: CMUST_11660(dcp)
CSP: WM42_0843
CPHO: CPHO_09910
CGV: CGLAU_09455(dcp)
CAQU: CAQU_09140
CAMG: CAMM_03050
CMIN: NCTC10288_02021(dcp)
NFA: NFA_20170
NFR: ERS450000_02093(dcp)
GBR: Gbro_3176
GPO: GPOL_c29540(dcp)
GOR: KTR9_3210
TPR: Tpau_2784
SCT: SCAT_4949(dcp)
SALU: DC74_4473
SALL: SAZ_23935
STRE: GZL_04386
SLD: T261_7413
KSK: KSE_54510(dcp)
CMI: CMM_1468(dcpA)
CMS: CMS1502
CMC: CMN_01445(dcpA)
MTS: MTES_3337
MALK: MalAC0309_2066(dcp)
ART: Arth_2313
ARR: ARUE_c24600(dcp)
ARX: ARZXY2_1660(dcp)
ACH: Achl_2039
AAI: AARI_17550(dcp)
BCV: Bcav_2254
JDE: Jden_1191
XCE: Xcel_1473
IDO: I598_0786(dcp)
CFL: Cfla_2016
CFI: Celf_1773
SERJ: SGUI_2285
BLIN: BLSMQ_0848
PFR: PFREUD_08030(dcp)
PFRE: RM25_0767
MPH: MLP_12170(dcp)
PSIM: KR76_16490
MGG: MPLG2_3058(dcp)
NDA: Ndas_1054
NAL: B005_2148
SRO: Sros_8022
NML: Namu_5074
GOB: Gobs_0938
BSD: BLASA_0800(dcp)
MMAR: MODMU_0991(dcp)
KRA: Krad_3616
AMD: AMED_4638(dcp)
AMN: RAM_23615
AMM: AMES_4582(dcp)
AMZ: B737_4582(dcp)
AOI: AORI_4103(dcp)
AJA: AJAP_18370(dcp)
AMQ: AMETH_3418(dcp)
PDX: Psed_0231
PSEE: FRP1_25430
CAI: Caci_5541
SNA: Snas_4856
AHE: Arch_1097
TPYO: X956_04345
RBA: RB7940(dcp)
PIR: VN12_16360(dcp)
FMR: Fuma_05178(dcp)
ABAS: ACPOL_5073
ABAC: LuPra_03234(dcp)
BOA: Bovatus_02918(dcp) Bovatus_04529(prlC)
BCEL: BcellWH2_03205(dcp) BcellWH2_04206(prlC)
PGI: PG_0758(dcp-1) PG_1789(dcp-2)
PGT: PGTDC60_0105(dcp-2) PGTDC60_1880(dcp-1)
PCRE: NCTC12858_01233(dcp_1) NCTC12858_01797(dcp_2)
PMUC: ING2E5A_2088(dcp1) ING2E5A_2212(dcp3)
PRU: PRU_0196 PRU_0685(dcp)
BLQ: L21SP5_03309(dcp_1) L21SP5_03492(dcp_2)
CPI: Cpin_5800
FLN: FLA_0079
SMIZ: 4412673_00118(dcp) 4412673_01271(prlC)
LBY: Lbys_3578
FLM: MY04_1913 MY04_2340(dcp)
GFO: GFO_1952(dcp)
FJG: BB050_01005(dcp) BB050_02088(prlC)
FPS: FP1364(dcp1) FP1883(dcp2)
FIN: KQS_02665(dcp1)
MARM: YQ22_11495
DOK: MED134_12176(dcp)
DDO: I597_1217(prlC)
ZGA: ZOBELLIA_2473(prlC)
MLT: VC82_804
NDO: DDD_2476
ELB: VO54_02110(prlC) VO54_03230(dcp)
CTAK: 4412677_01224(dcp) 4412677_02052(prlC)
WIN: WPG_0584
TMAR: MARIT_0785(dcp) MARIT_2225(dcp)
SPON: HME9304_00841(prlC)
MARF: CJ739_829
IAL: IALB_0980(dcp)
MRO: MROS_0606
 » show all
Taxonomy
Reference
1  [PMID:13271]
  Authors
Yaron A.
  Title
Dipeptidyl carboxypeptidase from Escherichia coli.
  Journal
Methods Enzymol 45:599-610 (1976)
DOI:10.1016/S0076-6879(76)45053-X
Reference
2  [PMID:8226676]
  Authors
Henrich B, Becker S, Schroeder U, Plapp R.
  Title
dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product.
  Journal
J Bacteriol 175:7290-300 (1993)
DOI:10.1128/JB.175.22.7290-7300.1993
  Sequence
[eco:b1538]
Reference
3  [PMID:7674945]
  Authors
Conlin CA, Miller CG.
  Title
Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium.
  Journal
Methods Enzymol 248:567-79 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.15.5
IUBMB Enzyme Nomenclature: 3.4.15.5
ExPASy - ENZYME nomenclature database: 3.4.15.5
BRENDA, the Enzyme Database: 3.4.15.5
CAS: 395642-28-1

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