KEGG   ENZYME: 3.4.16.2Help
Entry
EC 3.4.16.2                 Enzyme                                 

Name
lysosomal Pro-Xaa carboxypeptidase;
angiotensinase C;
lysosomal carboxypeptidase C;
peptidylprolylamino acid carboxypeptidase;
aminoacylproline carboxypeptidase;
prolyl carboxypeptidase;
carboxypeptidase P;
proline-specific carboxypeptidase P;
PCP;
lysosomal Pro-Xaa carboxypeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of a -Pro!Xaa bond to release a C-terminal amino acid
Comment
A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-X carboxypeptidase family).
History
EC 3.4.16.2 created 1972 as EC 3.4.12.4, transferred 1978 to EC 3.4.16.2
Orthology
K01285  lysosomal Pro-X carboxypeptidase
Genes
HSA: 5547(PRCP)
PTR: 451453(PRCP)
PPS: 100994652(PRCP)
GGO: 101151253(PRCP)
PON: 100172335(PRCP)
NLE: 100605917(PRCP)
MCC: 701305(PRCP)
MCF: 102131283(PRCP)
CSAB: 103248123(PRCP)
RRO: 104662004(PRCP)
RBB: 108531646(PRCP)
CJC: 100388965(PRCP)
SBQ: 101028738(PRCP)
MMU: 72461(Prcp)
RNO: 293118(Prcp)
CGE: 100752448(Prcp) 100753648
NGI: 103742987(Prcp) 103743050
HGL: 101719590(Prcp)
CCAN: 109696499(Prcp)
OCU: 100342764(PRCP)
TUP: 102479799(PRCP)
CFA: 476788(PRCP)
AML: 100470381(PRCP)
UMR: 103675337(PRCP)
ORO: 101369847(PRCP)
FCA: 101100665(PRCP)
PTG: 102970112(PRCP)
AJU: 106977068(PRCP)
BTA: 534927(PRCP)
BOM: 102272276(PRCP)
BIU: 109554554(PRCP)
PHD: 102325164(PRCP)
CHX: 102173817(PRCP)
OAS: 101107644(PRCP)
SSC: 100515678(PRCP)
CFR: 102505983(PRCP)
CDK: 105097619(PRCP)
BACU: 103017028(PRCP)
LVE: 103075949(PRCP)
OOR: 101270707(PRCP)
ECB: 100061830(PRCP)
EPZ: 103563552(PRCP)
EAI: 106830586(PRCP)
MYB: 102240105(PRCP)
MYD: 102774392(PRCP)
HAI: 109383279(PRCP)
RSS: 109458686(PRCP)
PALE: 102883802(PRCP)
LAV: 100670746(PRCP)
TMU: 101351178
MDO: 100616919(PRCP)
SHR: 100925337(PRCP)
OAA: 100083398(PRCP)
GGA: 428096(PRCP)
MGP: 100538774(PRCP)
CJO: 107308476(PRCP)
APLA: 101797257(PRCP)
ACYG: 106048041(PRCP)
TGU: 100223016(PRCP)
GFR: 102035555(PRCP)
FAB: 101818751(PRCP)
PHI: 102106218(PRCP)
PMAJ: 107212548(PRCP)
CCW: 104690347(PRCP)
FPG: 101918895(PRCP)
FCH: 102058300(PRCP)
CLV: 102091951(PRCP)
EGZ: 104129393(PRCP)
AAM: 106490815(PRCP)
ASN: 102384313(PRCP)
AMJ: 102562820(PRCP)
PSS: 102456311(PRCP)
CMY: 102934920(PRCP)
CPIC: 101946820(PRCP)
ACS: 100567778(prcp)
PVT: 110086908(PRCP)
PBI: 103052084(PRCP)
GJA: 107108458
XTR: 780095(prcp)
NPR: 108794632(PRCP)
DRE: 436967(prcp)
SGH: 107561745 107593474(prcp)
CCAR: 109051835(prcp) 109102882
IPU: 108277983(prcp)
AMEX: 103038921(prcp)
TRU: 101067785(prcp)
LCO: 104925967(prcp)
NCC: 104956555(prcp) 104967369
MZE: 101465206(prcp)
OLA: 101171930(prcp)
XMA: 102231920(prcp)
PRET: 103475021(prcp)
NFU: 107380188(prcp)
CSEM: 103377843(prcp)
LCF: 108876186(prcp)
HCQ: 109526216(prcp)
BPEC: 110163603(prcp)
ELS: 105006588(prcp)
SFM: 108941085(prcp)
LCM: 102348762(PRCP) 102349161
CMK: 103184608(prcp)
CIN: 100177495
SPU: 578398
APLC: 110975953
SKO: 100375180
DME: Dmel_CG2493(CG2493)
DSI: Dsimw501_GD21700(Dsim_GD21700)
MDE: 101891147
AAG: 5579822
AME: 551273
BIM: 100748772
BTER: 100645620
SOC: 105197999
AEC: 105145493
ACEP: 105626353
PBAR: 105427608
HST: 105191707
CFO: 105254089
LHU: 105668868
PGC: 109858997
DPA: 109533867
NVL: 108564204
BMOR: 101743731
PMAC: 106713385
PRAP: 110994998
ZNE: 110833401
TUT: 107366743
CEL: CELE_ZK112.1(pcp-1) CELE_ZK688.6(pcp-5)
CBR: CBG00035(Cbr-pcp-1.2) CBG00036(Cbr-pcp-1.1) CBG12259(Cbr-tag-282)
BMY: Bm1_07010
TSP: Tsp_06565
CRG: 105336248
MYI: 110455508
OBI: 106875422
SHX: MS3_00452
EGL: EGR_02952
EPA: 110253009
ADF: 107348231
HMG: 100208832
AQU: 100633804
LJA: Lj0g3v0204459.1(Lj0g3v0204459.1) Lj0g3v0204459.2(Lj0g3v0204459.2) Lj0g3v0204459.3(Lj0g3v0204459.3) Lj1g3v4723790.1(Lj1g3v4723790.1) Lj4g3v0696570.1(Lj4g3v0696570.1)
DOSA: Os01t0767100-01(Os01g0767100) Os06t0647400-02(Os06g0647400) Os11t0156200-01(Os11g0156200)
ATS: 109746000(LOC109746000) 109748550(LOC109748550) 109748552(LOC109748552) 109748553(LOC109748553) 109748554(LOC109748554) 109748555(LOC109748555) 109772445(LOC109772445)
PPP: 112284284
APRO: F751_0318
DFA: DFA_07762
SMIN: v1.2.027597.t1(symbB.v1.2.027597.t1)
 » show all
Taxonomy
Reference
1  [PMID:6991912]
  Authors
Walter R, Simmons WH, Yoshimoto T.
  Title
Proline specific endo- and exopeptidases.
  Journal
Mol Cell Biochem 30:111-27 (1980)
Reference
2  [PMID:7341916]
  Authors
Odya CE, Erdos EG.
  Title
Human prolylcarboxypeptidase.
  Journal
Methods Enzymol 80 Pt C:460-6 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.2
IUBMB Enzyme Nomenclature: 3.4.16.2
ExPASy - ENZYME nomenclature database: 3.4.16.2
BRENDA, the Enzyme Database: 3.4.16.2
CAS: 9075-64-3

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