Entry
Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5--6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289 cathepsin A (carboxypeptidase C)
Genes
TUP : 102485953(CTSA) 102488508
LAV : 100665041(CTSA) 100676352
ETF : 101652615 101655929(CTSA)
DNM : 101417051 101433099(CTSA)
MDO : 100022069(CTSA) 100024941
GAS : 123234560 123237282(CTSA)
SHR : 100915300 100933780(CTSA)
PCW : 110192388 110193676(CTSA)
TVP : 118842690 118844471(CTSA)
PBRV : 138141846(CTSA) 138160764
TACU : 119931351(CTSA) 119934991
SVG : 106860883(CTSA) 106861627
ASN : 102368270 102373938(CTSA)
AMJ : 102564952(CTSA) 102572879
CPOO : 109310441 109313296(CTSA)
GGN : 109289682 109292477(CTSA)
ACS : 100559820 100561404(ctsa)
SUND : 121926149 121929867(CTSA)
PBI : 103049522(CTSA) 112541987
PGUT : 117669608(CTSA) 117670332
APRI : 131184420 131194703(CTSA)
PMUA : 114599892(CTSA) 114601854
PRAF : 128416728(CTSA) 128419075
ZVI : 118086888 118089308(CTSA)
HCG : 128323893(CTSA) 128342306 128342328
RTEM : 120918572 120918573
BGAR : 122940925 122941848(CTSA)
MUO : 115475938 115475945 115475946
DRE : 321818(ctsa) 792966(si:ch211-122f10.4)
SRX : 107707902 107740260 107744356
SANH : 107666023 107695338 107696438 107702181
SGH : 107560512 107587598 107596457
CAUA : 113051376 113104924(ctsa) 113106308
CGIB : 127959378 127962648 128017744(si:ch211-122f10.4)
PTET : 122347083(ctsa) 122349615(si:ch211-122f10.4)
LROH : 127166817(ctsa) 127167871(si:ch211-122f10.4)
OMC : 131542062(ctsa) 131544898(si:ch211-122f10.4)
PPRM : 120477274(si:ch211-122f10.4) 120494162(ctsa)
RKG : 130091200(si:ch211-122f10.4) 130104148(ctsa)
MAMB : 125264042(si:ch211-122f10.4) 125273350(ctsa)
CIDE : 127514674 127515385(si:ch211-122f10.4)
CERY : 137011182(ctsa) 137030305(si:ch211-122f10.4)
MASI : 127444637 127446017 127449570
TROS : 130556422(ctsa) 130556806(si:ch211-122f10.4)
TDW : 130424275 130424276 130430079(si:ch211-122f10.4)
MANU : 129435451 129448368(si:ch211-122f10.4) 129450137(ctsa)
AMEX : 103027152(si:ch211-122f10.4) 103035030(ctsa)
CMAO : 118808512(ctsa) 118814990(si:ch211-122f10.4)
EEE : 113569846 113571584(ctsa)
CHAR : 105895926(ctsa) 105907212(si:ch211-122f10.4) 105910362 122131063
SPIL : 134069292(si:ch211-122f10.4) 134093028(ctsa) 134093811
TRU : 101066746(ctsa) 101077421
TFS : 130516909(si:ch211-122f10.4) 130523958(ctsa)
LCO : 104927289 104933133(ctsa)
TBEN : 117471429(si:ch211-122f10.4) 117499321(ctsa)
PGEO : 117468269(si:ch211-122f10.4)
GACU : 117533255(si:ch211-122f10.4) 117551906(ctsa)
EMAC : 134863175(si:ch211-122f10.4) 134882935(ctsa)
ELY : 117254112(si:ch211-122f10.4) 117256367(ctsa)
EFO : 125889223(ctsa) 125901626(si:ch211-122f10.4)
PLEP : 121940545 121957060(si:ch211-122f10.4)
SLUC : 116060544(si:ch211-122f10.4) 116062611(ctsa)
ECRA : 117941192 117943103(si:ch211-122f10.4)
PFLV : 114554751(ctsa) 114565953
GAT : 120833441(si:ch211-122f10.4) 120834957(ctsa)
PPUG : 119194168(si:ch211-122f10.4) 119230065(ctsa)
AFB : 129099731(si:ch211-122f10.4) 129105724(ctsa)
CLUM : 117730418(ctsa) 117748441(si:ch211-122f10.4)
PSWI : 130192942(si:ch211-122f10.4) 130209063(ctsa)
CANA : 137786689(si:ch211-122f10.4) 137795990(ctsa)
CVE : 137880743(ctsa) 137887449(si:ch211-122f10.4)
MSAM : 119886135(ctsa) 119890104 119890996(si:ch211-122f10.4)
SCHU : 122869308(ctsa) 122874159(si:ch211-122f10.4)
CUD : 121506762(si:ch211-122f10.4) 121507447(ctsa)
SPUL : 138587212 138605649(ctsa)
LMIX : 132977200(ctsa) 132979891(si:ch211-122f10.4)
ALAT : 119017888(si:ch211-122f10.4) 119020547(ctsa)
ASTR : 137595191(ctsa) 137595485(si:ch211-122f10.4)
MZE : 101480742 101482934(ctsa) 112429970
ONL : 100700252(ctsa) 100706635
OAU : 116312697(ctsa) 116334576(si:ch211-122f10.4)
OLA : 101168356 101173697(ctsa)
OML : 112145598 112145599 112160554(si:ch211-122f10.4)
CSAI : 133449587(ctsa) 133462672(si:ch211-122f10.4)
XMA : 102229123 102234395(ctsa)
XCO : 114135284(ctsa) 114142723
PRET : 103460358(ctsa) 103462555
PFOR : 103131224(ctsa) 103136588
PLAI : 106937032(ctsa) 106948990
PMEI : 106904099(ctsa) 106921974
GAF : 122833411(ctsa) 122843268(si:ch211-122f10.4)
PPRL : 129355171 129356294 129364018(si:ch211-122f10.4)
CVG : 107102985 107103547(ctsa) 107105074
CTUL : 119788650(ctsa) 119798977(si:ch211-122f10.4)
GMU : 124856607(ctsa) 124866555(si:ch211-122f10.4)
NFU : 107373363 107381336 107384873(ctsa)
KMR : 108250713(ctsa) 108251491(si:ch211-122f10.4)
ALIM : 106531749(ctsa) 106532157
NWH : 119412669(ctsa) 119428549(si:ch211-122f10.4)
AOCE : 111571413(ctsa) 111587671
EJA : 138212924 138214270(ctsa)
BFRE : 138614470(ctsa) 138618081
MCEP : 125005312 125007094(ctsA)
CSEM : 103378882 103386821(ctsa)
POV : 109636834 109647685(ctsa)
SSEN : 122768165(ctsa) 122772409(si:ch211-122f10.4)
HHIP : 117753376(si:ch211-122f10.4) 117762170(ctsa)
HSP : 118105350(ctsa) 118105939(si:ch211-122f10.4)
PPLT : 128436563(si:ch211-122f10.4) 128450563(ctsa)
SMAU : 118301806(si:ch211-122f10.4) 118309120(ctsa)
LCF : 108877788(si:ch211-122f10.4) 108890718
SDU : 111217614 111219402(ctsa)
SLAL : 111646244 111656535(ctsa)
XGL : 120783358(ctsa) 120804373(si:ch211-122f10.4)
HCQ : 109522647(ctsa) 109525936
SSCV : 125967600(si:ch211-122f10.4) 125977314(ctsa)
SBIA : 133497895(si:ch211-122f10.4) 133507637(ctsa)
PEE : 133396177(si:ch211-122f10.4) 133408806(ctsa)
PTAO : 133474418(si:ch211-122f10.4) 133483792(ctsa)
MALB : 109964585 109966949(ctsa)
BSPL : 114852309(si:ch211-122f10.4) 114855077(ctsa)
SJO : 128355451(ctsa) 128356025(si:ch211-122f10.4)
SSCO : 133978015(ctsa) 133983173(si:ch211-122f10.4)
SASA : 100195153(ctsa) 106562245 106587401
STRU : 115150090(ctsa) 115203138
OTW : 112249206 112255041(ctsa) 112263741
OMY : 110506581(si:ch211-122f10.4) 110528562(ctsa)
OGO : 124026161(ctsa) 124033111 124035690
ONE : 115112317 115112318 115144189(ctsa)
OKI : 109882442 109891427(ctsa)
OKE : 118359927 118393911 118400616(ctsa)
OMM : 135541372(ctsa) 135549695 135558672
SALP : 111969419 111970521(ctsa) 111974269
SNH : 120025180 120056261 120065464(ctsa)
CCLU : 121548264(si:ch211-122f10.4) 121575587 121577970(ctsa)
ELS : 105016109 105016705(ctsa)
SFM : 108936511(ctsa) 108937935
PKI : 111835880(ctsa) 111846630
AANG : 118211793(ctsa) 118226845(si:ch211-122f10.4)
AROT : 135238051(ctsa) 135255779(si:ch211-122f10.4)
CCOG : 133109696(ctsa) 133131667(si:ch211-122f10.4)
LOC : 102691640(ctsa) 102698583 102698789
PSPA : 121298046(ctsa) 121320200 121325949(si:ch211-122f10.4)
ARUT : 117399404 117425024(si:ch211-122f10.4) 117425942 117431553
PSEX : 120515128(ctsa) 120534856 120535305(si:ch211-122f10.4)
LCM : 102354641(CTSA) 102367606
RTP : 109920830 109929856 109938362
CPLA : 122540777(ctsa) 122558590 122558591(si:ch211-122f10.4)
HOC : 132822863(ctsa) 132823806 132824037(si:ch211-122f10.4)
LERI : 129705241 129705242 129707211(ctsa)
PMRN : 116944295(CTSA) 116944296 116952018
LRJ : 133350990 133350991 133354801
BBEL : 109473640 109480593
SCLV : 120326519 120338425
SPU : 588485 589075 594128
LPIC : 129253824 129253985 129254278 129270709 129280110
ARUN : 117288990 117289229 117289495
AJC : 117107562 117113986 117114027
PFLL : 139147438 139147440 139147441 139147442 139147443 139147444 139147920
MRJ : 136832512 136832517 136832564
HAZT : 108665481 108680621 108682879
DSV : 119432355 119432876 119432929 119433908 119434102 119434103 119445287 119445696
RSAN : 119377832 119405002 119405126 119405451 119405538
RMP : 119176385 119180547 119180706 119181713 119181714 119186027
CEL : CELE_F13D12.6(ctsa-1.2) CELE_F41C3.5(ctsa-1.1) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-4.2)
CBR : CBG_03132 CBG_04280 CBG_15195
CRQ : GCK72_003823 GCK72_005565 GCK72_025641
LGI : LOTGIDRAFT_159616 LOTGIDRAFT_206131
PVUL : 126812113 126812114
LSAX : 138973067 138973069 138973070 138973073 138973081
HRF : 124131380 124131632 124131700
HRJ : 124254268 124254318 124254319
HASI : 137257720 137257774 137258081 137258082 137258083
AIRR : 138315375 138315377 138315378
SMM : Smp_163970 Smp_172590
TDC : 119297522 119304092 119323407
SCE : YBR139W(ATG42) YMR297W(PRC1)
SEUB : DI49_1168 DI49_4384
SPAO : SPAR_B02380 SPAR_M04120
AGO : AGOS_AER022W AGOS_AGL328C
KLA : KLLA0_A09977g KLLA0_C17490g KLLA0_E17821g
KMX : KLMA_10499(PRC1) KLMA_60138
LTH : KLTH0B09328g KLTH0G15950g
VPO : Kpol_1028p72 Kpol_1036p14
ZRO : ZYRO0B05720g ZYRO0D07260g
CGR : 2891228(GVI51_M13629)
NCS : NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI : NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF : TPHA_0A05520(TPHA0A05520)
TBL : TBLA_0C06920(TBLA0C06920)
TDL : TDEL_0G00500(TDEL0G00500)
KAF : KAFR_0I02520(KAFR0I02520)
KNG : KNAG_0E01520(KNAG0E01520) KNAG_0K01950(KNAG0K01950)
ZMK : HG535_0C03120 HG535_0E00490
SLUD : SCDLUD_002512 SCDLUD_004850
DHA : DEHA2C13112g DEHA2D02244g
PIC : PICST_31676 PICST_36810 PICST_38351(CPY2)
PGU : PGUG_05015 PGUG_05150
SPAA : SPAPADRAFT_48326 SPAPADRAFT_63508
LEL : PVL30_004203 PVL30_004204 PVL30_005295(CPY1)
LBG : 92207896(LODBEIA_P27000) 92210323(LODBEIA_P51270) 92210324(LODBEIA_P51280) 92211276(LODBEIA_P60800)
CAL : CAALFM_C105770CA(PRC3) CAALFM_C501450WA(PRC2) CAALFM_C703360WA(CPY1)
CTP : CTRG_00505 CTRG_04821 CTRG_05137
COT : CORT_0B08710 CORT_0E03430 CORT_0G03840
CDU : CD36_05440(CPY2) CD36_50900 CD36_73010
CTEN : 18246576(CPY1) 18250813(PSN45_000499)
CLU : CLUG_00466 CLUG_02976
CLUS : A9F13_08g02750 A9F13_18g00847
CAUR : CJI96_0002324 CJI96_0004578
PKZ : C5L36_0A05800 C5L36_0B00410
OPA : HPODL_02015 HPODL_04650
YLI : 2906337(YALI2_A00287g) 2907325(YALI2_C00662g) 2907575(YALI2_B00627g) 2908637(YALI2_F00231g) 2909165(YALI2_C00018g) 2909590(YALI2_B00313g) 2909825(YALI2_B00396g) 2910686(YALI2_D00929g) 2910952(YALI2_D00952g)
NTE : NEUTE1DRAFT82484(NEUTE1DRAFT_82484)
SMP : 10806348(SMAC4_01911)
FGR : FGSG_03769 FGSG_06895
FPU : FPSE_03477 FPSE_11764
FPOA : FPOAC1_005860 FPOAC1_006180 FPOAC1_010645
FVN : FVRRES_06468 FVRRES_06783 FVRRES_11642
FVR : FVEG_12878 FVEG_14045
NHE : NECHADRAFT_100110 NECHADRAFT_44892
FFC : NCS54_00023600 NCS54_00023700 NCS54_00566300 NCS54_00914800 NCS54_01301400
FKR : NCS57_00484700 NCS57_00604200 NCS57_00932300 NCS57_01287500 NCS57_01287600
FMU : J7337_002660 J7337_012354 J7337_013644
TATV : 25776741(TrAtP1_008493) 25782052(TrAtP1_004144)
TASP : 36607222(TrAFT101_003621) 36619255(TrAFT101_002909)
MAW : 19247277(CPY1_8) 19248591(CPY1_1) 19250451(J3458_004746)
MAJ : MAA_02797 MAA_05766 MAA_07696
MBRN : 26238666(CPYA_0) 26241703(CPYA_2) 26242491(CPYA_1)
PCHM : VFPPC_02945 VFPPC_07015 VFPPC_07181 VFPPC_12520 VFPPC_18483
CMT : CCM_02146 CCM_05858 CCM_06411
AMUS : LMH87_001042 LMH87_002027 LMH87_003224 LMH87_008253
PLJ : 28887545(PLICBS_002788) 28892527(PLICBS_006446)
PTKZ : JDV02_001062 JDV02_006067(CPY1) JDV02_008131
CLUP : CLUP02_03399 CLUP02_09266
CHIG : CH63R_02503 CH63R_07060 CH63R_14020 CH63R_14024
CDET : 87937237(CDEST_00734) 87944236(CDEST_07733) 87947587(CDEST_11087) 87947589(CDEST_11089) 87947590(CDEST_11090)
BFU : BCIN_10g04320(Bccp4)
AFM : AFUA_3G12210 AFUA_5G14610 AFUA_6G13540
ACT : ACLA_040070 ACLA_086840 ACLA_098670
NFI : NFIA_059500 NFIA_065090 NFIA_072360
ANG : An05g01870 An08g08750(cpy) An11g06350
ALUC : AKAW2_11962A AKAW2_51701A AKAW2_81337S
ACHE : ACHE_10104S ACHE_20311S
CIM : CIMG_02815 CIMG_09968
CPW : 9696555(D8B26_000643) 9697464(D8B26_007065)
URE : UREG_03020 UREG_06044
PNO : SNOG_02053 SNOG_08837
PTRR : 6341350(PtrM4_067280) 6348766(PtrM4_078620)
BZE : COCCADRAFT_104639 COCCADRAFT_33067
BSC : COCSADRAFT_106369 COCSADRAFT_41809
BOR : COCMIDRAFT_38160 COCMIDRAFT_5305
AALT : CC77DRAFT_1037795 CC77DRAFT_936276
ADAC : 96080913(ACET3X_000591) 96083179(ACET3X_002857)
ARAB : EKO05_0007010 EKO05_0008993
NPA : UCRNP2_8337 UCRNP2_9391
CNG : CNAG_01879 CNAG_06640
CGI : CGB_F1460W CGB_K1610W
CDEU : CNBG_1925 CNBG_3062
CDEP : 91086729(L203_102517) 91090579(L203_106371)
KMG : 30160990(I203_105360) 30164500(I203_106213)
KNE : 92179261(IAR55_002002) 92183429(IAR55_006171) 92183617(IAR55_006359) 92183634(IAR55_006376) 92184375(IAR55_007117)
TMS : TREMEDRAFT_33109 TREMEDRAFT_45442
CCAC : CcaHIS019_0600800(CcaverHIS019_0600800)
TVS : TRAVEDRAFT_60064 TRAVEDRAFT_66190
DSQ : DICSQDRAFT_180596 DICSQDRAFT_89934
PCO : PHACADRAFT_248586 PHACADRAFT_261985
SHS : STEHIDRAFT_116990 STEHIDRAFT_63455
HIR : HETIRDRAFT_30479 HETIRDRAFT_68367
PSQ : PUNSTDRAFT_123335 PUNSTDRAFT_49136
ADL : AURDEDRAFT_179551 AURDEDRAFT_74128
FME : FOMMEDRAFT_118650 FOMMEDRAFT_164247
GTR : GLOTRDRAFT_108844 GLOTRDRAFT_60042
RSX : RhiXN_09955 RhiXN_09962 RhiXN_12145
LBC : LACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
CCI : CC1G_09180 CC1G_12159
ABP : AGABI1DRAFT111650(AGABI1DRAFT_111650) AGABI1DRAFT115480(AGABI1DRAFT_115480)
ABV : AGABI2DRAFT139843(AGABI2DRAFT_139843) AGABI2DRAFT190884(AGABI2DRAFT_190884)
PCUB : JR316_0001407 JR316_0001409 JR316_0001463 JR316_0003113
MRR : Moror_1683 Moror_4726
MORE : E1B28_002378 E1B28_009549
SCM : SCHCO_02485498(SCHCODRAFT_02485498) SCHCO_02521311(SCHCODRAFT_02521311)
CPUT : CONPUDRAFT_109529 CONPUDRAFT_85714
SLA : SERLADRAFT_453678 SERLADRAFT_457076
UMA : UMAG_01886 UMAG_04641
SGRA : EX895_001410 EX895_002209 EX895_003973
RIE : OCT59_010901 OCT59_012036
TET : TTHERM_00249550 TTHERM_00249560 TTHERM_00249570 TTHERM_00249680 TTHERM_00249710 TTHERM_00249800 TTHERM_00346900 TTHERM_00448920 TTHERM_00448930 TTHERM_00448980 TTHERM_00927190 TTHERM_00927200 TTHERM_00927210 TTHERM_00927220 TTHERM_01141610
PTI : PHATRDRAFT_11204 PHATR_18551
PIF : PITG_01447 PITG_11525
TBR : Tb10.70.7080 Tb10.70.7090 Tb10.70.7100
TBG : TbgDal_X1360 TbgDal_X1380 TbgDal_X1400 TbgDal_X1410
TCR : 508671.20 509695.210 509695.220 509695.230
LMAT : 92516612(LSCM1_06690)
LOI : 92362886(LSCM4_07047)
LEIS : 94182327(GH5_07059)
LENR : 94174165(CUR178_07006)
LEIN : 94189463(JIQ42_05843)
PHET : 94292555(JKF63_06529) 94292570(JKF63_06544)
» show all
Taxonomy
Reference
1
Authors
Breddam K.
Title
Serine carboxypeptidases. A review.
Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH
Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
Journal
Sequence
Reference
Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
Journal
J Biol Chem 267:2872-5 (1992)
Reference
Authors
Miller JJ, Changaris DG, Levy RS.
Title
Purification, subunit structure and inhibitor profile of cathepsin A.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.5
ExPASy - ENZYME nomenclature database: 3.4.16.5