KEGG   ENZYME: 3.4.16.5Help
Entry
EC 3.4.16.5                 Enzyme                                 

Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289  cathepsin A (carboxypeptidase C)
Genes
HSA: 5476(CTSA)
PTR: 458290(CTSA)
PPS: 100969338(CTSA)
GGO: 101150972(CTSA)
PON: 100173381(CTSA)
NLE: 100584301(CTSA)
MCC: 708592(CTSA)
MCF: 101866185(CTSA)
CSAB: 103245139(CTSA)
RRO: 104678820(CTSA)
RBB: 108533329(CTSA)
CJC: 100413773(CTSA)
SBQ: 101033824(CTSA)
MMU: 19025(Ctsa)
RNO: 296370(Ctsa)
CGE: 100772055(Ctsa)
NGI: 103737935(Ctsa)
HGL: 101720484(Ctsa)
CCAN: 109689272(Ctsa)
OCU: 100339600(CTSA)
TUP: 102485953(CTSA) 102488508
CFA: 611146(CTSA)
AML: 100474665(CTSA)
UMR: 103669857(CTSA)
ORO: 101379146(CTSA)
FCA: 101085538
PTG: 102958713(CTSA)
AJU: 106969007(CTSA)
BTA: 518169(CTSA)
BOM: 102280027(CTSA)
BIU: 109567503(CTSA)
PHD: 102322563(CTSA)
CHX: 102182324(CTSA)
OAS: 101113615(CTSA)
SSC: 100156798(CTSA)
CFR: 102508708(CTSA)
CDK: 105087842(CTSA)
BACU: 103017862(CTSA)
LVE: 103087262(CTSA)
OOR: 101276848(CTSA)
ECB: 100071127(CTSA)
EPZ: 103551923(CTSA)
EAI: 106843038(CTSA)
MYB: 102259776(CTSA)
MYD: 102766118(CTSA)
HAI: 109379946(CTSA)
RSS: 109457055(CTSA)
PALE: 102888117(CTSA)
LAV: 100665041(CTSA) 100676352
TMU: 101347053
MDO: 100022069(CTSA) 100024941
SHR: 100915300 100933780(CTSA)
OAA: 100076065(CTSA)
GGA: 428163(CTSA)
MGP: 100547907(CTSA)
CJO: 107323140(CTSA)
APLA: 101801880(CTSA)
ACYG: 106047180(CTSA)
TGU: 100220062(CTSA)
GFR: 102038566(CTSA)
FAB: 101812393(CTSA)
PHI: 102113628(CTSA)
PMAJ: 107213227(CTSA)
CCW: 104687726(CTSA)
FPG: 101912460(CTSA)
FCH: 102045880(CTSA)
CLV: 102087924(CTSA)
EGZ: 104127960(CTSA)
AAM: 106497597(CTSA)
ASN: 102368270 102373938(CTSA)
AMJ: 102564952(CTSA) 102572879
PSS: 102460692(CTSA)
CMY: 102942772(CTSA)
CPIC: 101938768(CTSA)
ACS: 100559820 100561404(ctsa)
PVT: 110086236(CTSA)
PBI: 103049522(CTSA)
GJA: 107111356(CTSA)
XLA: 494810(ctsa.L)
XTR: 734066(ctsa)
NPR: 108793373(CTSA)
DRE: 321818(ctsa) 792966(si:ch211-122f10.4)
SRX: 107744356
SANH: 107666023
SGH: 107560512
CCAR: 109052126(ctsa)
IPU: 108271760(ctsa)
AMEX: 103035030(ctsa)
TRU: 101066746(ctsa) 101077421
LCO: 104927289 104933133(ctsa)
NCC: 104945215
MZE: 101480742 101482934(ctsa)
OLA: 101168356 101173697(ctsa)
XMA: 102229123 102234395(ctsa)
PRET: 103460358(ctsa)
NFU: 107384873(ctsa)
CSEM: 103386821(ctsa)
LCF: 108890718(ctsa)
HCQ: 109522647(ctsa)
BPEC: 110175414(ctsa)
ELS: 105016705(ctsa)
SFM: 108936511(ctsa)
LCM: 102354641(CTSA) 102367606
CMK: 103191463(ctsa)
APLC: 110988405
SKO: 100370840
TUT: 107366517
CEL: CELE_F13D12.6(F13D12.6) CELE_F41C3.5(F41C3.5) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-2)
BMY: Bm1_43130
MYI: 110453620
OBI: 106874211
LAK: 106171672
SCE: YBR139W YMR297W(PRC1)
NCS: NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI: NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF: TPHA_0A05520(TPHA0A05520)
TBL: TBLA_0C06920(TBLA0C06920)
TDL: TDEL_0G00500(TDEL0G00500)
KAF: KAFR_0I02520(KAFR0I02520)
SLB: AWJ20_4686(PRC1)
NCR: NCU00477
NTE: NEUTE1DRAFT82484(NEUTE1DRAFT_82484)
MGR: MGG_05663
MAW: MAC_06140
MAJ: MAA_05766
CMT: CCM_05858
BFU: BCIN_10g04320(Bccp4)
MBE: MBM_01234
ANI: AN5442.2
ANG: ANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
SPO: SPAC19G12.10c(cpy1)
LBC: LACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
MGL: MGL_0285
LLO: LLO_1568
 » show all
Taxonomy
Reference
1
  Authors
Breddam, K.
  Title
Serine carboxypeptidases. A review.
  Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
2  [PMID:3028649]
  Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH.
  Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
  Journal
Cell 48:887-97 (1987)
DOI:10.1016/0092-8674(87)90085-7
  Sequence
[sce:YMR297W]
Reference
3  [PMID:1737744]
  Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
  Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
  Journal
J Biol Chem 267:2872-5 (1992)
Reference
4  [PMID:1487525]
  Authors
Miller JJ, Changaris DG, Levy RS.
  Title
Purification, subunit structure and inhibitor profile of cathepsin A.
  Journal
J Chromatogr 627:153-62 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.5
IUBMB Enzyme Nomenclature: 3.4.16.5
ExPASy - ENZYME nomenclature database: 3.4.16.5
BRENDA, the Enzyme Database: 3.4.16.5
CAS: 9046-67-7

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