KEGG   ENZYME: 3.4.17.10Help
Entry
EC 3.4.17.10                Enzyme                                 

Name
carboxypeptidase E;
carboxypeptidase H;
enkephalin convertase;
cobalt-stimulated chromaffin granule carboxypeptidase;
insulin granule-associated carboxypeptidase;
enkephalin convertase;
membrane-bound carboxypeptidase;
carboxypeptidase E;
enkephalin-precursor endopeptidase;
enkephalin precursor carboxypeptidase;
peptidyl-L-lysine(-L-arginine) hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of C-terminal arginine or lysine residues from polypeptides
Comment
A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.10 created 1986, modified 2000
Orthology
K01294  carboxypeptidase E
Genes
HSA: 1363(CPE)
PTR: 461592(CPE)
PPS: 100983801(CPE)
GGO: 101136106(CPE)
PON: 100458397(CPE)
NLE: 100603608(CPE)
MCC: 708881(CPE)
MCF: 101926881(CPE)
CSAB: 103236491(CPE)
RRO: 104663436(CPE)
RBB: 108521930(CPE)
CJC: 100397838(CPE)
SBQ: 101051920(CPE)
MMU: 12876(Cpe)
RNO: 25669(Cpe)
CGE: 100757401(Cpe)
NGI: 103727151(Cpe)
HGL: 101719011(Cpe)
CCAN: 109687903(Cpe)
TUP: 102501876(CPE)
CFA: 475492(CPE)
AML: 100475157(CPE)
UMR: 103658128(CPE)
ORO: 101385133(CPE)
FCA: 101080963(CPE)
PTG: 102969754(CPE)
AJU: 106967484(CPE)
BTA: 280753(CPE)
BOM: 102278899(CPE)
BIU: 109571486(CPE)
PHD: 102326479(CPE)
CHX: 102191726(CPE)
OAS: 443028(CPE)
SSC: 100037304(CPE)
CFR: 102519597(CPE)
CDK: 105089282(CPE)
BACU: 103006962(CPE)
LVE: 103090381(CPE)
OOR: 101288868(CPE)
ECB: 100061513(CPE)
EPZ: 103568033(CPE)
EAI: 106837735(CPE)
MYB: 102263369(CPE)
MYD: 102762285(CPE)
HAI: 109386961(CPE)
RSS: 109454219(CPE)
PALE: 102881821(CPE)
LAV: 100673979(CPE)
TMU: 101342305
MDO: 100021886(CPE)
OAA: 100078274(CPE)
GGA: 422424(CPE)
MGP: 100551301(CPE)
CJO: 107313017(CPE)
APLA: 101791161(CPE)
ACYG: 106032323(CPE)
TGU: 100221584(CPE)
GFR: 102034548(CPE)
FAB: 101815330(CPE)
PHI: 102111561(CPE)
PMAJ: 107203328(CPE)
CCAE: 111927887(CPE)
CCW: 104690531(CPE)
FPG: 101918946(CPE)
FCH: 102052005(CPE)
CLV: 102087027(CPE)
EGZ: 104124050(CPE)
AAM: 106484070(CPE)
ASN: 102374554(CPE)
AMJ: 102570894(CPE)
PSS: 102449554(CPE)
CMY: 102930293(CPE)
CPIC: 101943255(CPE)
ACS: 100552346(cpe)
PVT: 110083481(CPE)
PBI: 103058963(CPE)
GJA: 107110627(CPE) 107125076
XLA: 100158368(cpe.L) 100158417(cpe.S)
XTR: 100127580(cpe)
NPR: 108788888(CPE)
DRE: 407979(cpe)
SANH: 107655967(cpe) 107702282
IPU: 108260799(cpe)
AMEX: 111195201(cpe)
TRU: 101070693(cpe)
LCO: 104933865(cpe)
NCC: 104962900(cpe)
MZE: 101480085(cpe)
OLA: 101160712(cpe)
XMA: 102232385(cpe)
PRET: 103460607(cpe)
NFU: 107374118(cpe)
KMR: 108231654(cpe)
CSEM: 103384084(cpe)
SDU: 111216731(cpe)
HCQ: 109511155(cpe)
BPEC: 110167556(cpe)
MALB: 109972120(cpe)
ELS: 105007587(cpe)
SFM: 108924563(cpe)
CMK: 103177339(cpe)
CIN: 100184198
SPU: 757239
SKO: 100368040
TCA: 661126
DPA: 109538435
NVL: 108563898
BMOR: 101740426
PMAC: 106714818
PRAP: 110998514
HAW: 110378989
DNX: 107171599
CLEC: 106669270
ZNE: 110838058
FCD: 110856293
TUT: 107369460
CEL: CELE_F01D4.4(egl-21)
CBR: CBG08337(Cbr-egl-21)
BMY: Bm1_54515
CRG: 105329096
MYI: 110448592
OBI: 106873361
LAK: 106176829
SHX: MS3_06451
 » show all
Taxonomy
Reference
1  [PMID:10206965]
  Authors
Qian Y, Varlamov O, Fricker LD.
  Title
Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway.
  Journal
J Biol Chem 274:11582-6 (1999)
DOI:10.1074/jbc.274.17.11582
Reference
2
  Authors
Fricker, L.D.
  Title
Carboxypeptidase E/H.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1341-1344.
Reference
3
  Authors
Fricker, L.D.
  Title
Methods for studying carboxypeptidase E.
  Journal
Methods Neurosci 23:237-250 (1995)
Reference
4  [PMID:2334405]
  Authors
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L.
  Title
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
  Journal
Biochem J 267:517-25 (1990)
  Sequence
[hsa:1363] [rno:25669]
Reference
5  [PMID:2897826]
  Authors
Fricker LD.
  Title
Carboxypeptidase E.
  Journal
Annu Rev Physiol 50:309-21 (1988)
DOI:10.1146/annurev.ph.50.030188.001521
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.10
IUBMB Enzyme Nomenclature: 3.4.17.10
ExPASy - ENZYME nomenclature database: 3.4.17.10
BRENDA, the Enzyme Database: 3.4.17.10
CAS: 81876-95-1

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