KEGG   ENZYME: 3.4.17.12Help
Entry
EC 3.4.17.12                Enzyme                                 

Name
carboxypeptidase M;
CPM
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of C-terminal arginine or lysine residues from polypeptides
Comment
A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)
History
EC 3.4.17.12 created 1992
Orthology
K01296  carboxypeptidase M
Genes
HSA: 1368(CPM)
PTR: 452067(CPM)
PPS: 100969689(CPM)
GGO: 101130328(CPM)
PON: 100171502(CPM)
NLE: 100602479(CPM)
MCC: 718315(CPM)
MCF: 102138123(CPM)
CSAB: 103238691(CPM)
RRO: 104658666(CPM)
RBB: 108532256(CPM)
CJC: 100410597(CPM)
SBQ: 101040778(CPM)
MMU: 70574(Cpm)
RNO: 314855(Cpm)
CGE: 100770407(Cpm)
NGI: 103745080(Cpm)
HGL: 101724468(Cpm)
CCAN: 109693329(Cpm)
OCU: 100349485(CPM) 108176913
TUP: 102474632(CPM)
CFA: 100685525(CPM)
AML: 100481997(CPM)
UMR: 103656872(CPM)
ORO: 101386105(CPM)
FCA: 101097407(CPM)
PTG: 102967223(CPM)
AJU: 106966349(CPM)
BTA: 513281(CPM)
BOM: 102287201(CPM)
BIU: 109559246(CPM)
PHD: 102338908(CPM)
CHX: 102172872(CPM)
OAS: 101104474(CPM)
SSC: 100628221(CPM)
CFR: 102522173(CPM)
CDK: 105101084(CPM)
BACU: 103017503(CPM)
LVE: 103081156(CPM)
OOR: 101286496(CPM)
ECB: 100059473(CPM)
EPZ: 103558164(CPM)
EAI: 106843580(CPM)
MYB: 102256624(CPM)
MYD: 102770875(CPM)
HAI: 109381649(CPM)
RSS: 109456594(CPM)
PALE: 102884706(CPM)
LAV: 100665759(CPM)
TMU: 101349661
MDO: 100021372(CPM)
SHR: 100921178(CPM)
OAA: 100080749(CPM)
GGA: 417843(CPM)
MGP: 100543962(CPM)
CJO: 107310518(CPM)
APLA: 101789743(CPM)
ACYG: 106045412(CPM)
TGU: 100225708(CPM)
GFR: 102037874(CPM)
FAB: 101813399(CPM)
PHI: 102101701(CPM)
PMAJ: 107204719(CPM)
CCAE: 111937509(CPM)
CCW: 104698374(CPM)
FPG: 101923955(CPM)
FCH: 102048341(CPM)
CLV: 102085565(CPM)
EGZ: 104132947(CPM)
AAM: 106488152(CPM)
ASN: 102385520(CPM)
AMJ: 102562411(CPM)
PSS: 102463630(CPM)
CMY: 102930730(CPM)
CPIC: 101936032(CPM)
ACS: 100556918(cpm)
PVT: 110075131(CPM)
PBI: 103063247(CPM)
GJA: 107105717(CPM)
XLA: 108711091(cpm.L) 108713154(cpm.S)
XTR: 496721(cpm)
NPR: 108804545(CPM)
DRE: 550253(cpm)
SGH: 107579274 107590974(cpm)
IPU: 108279953(cpm)
AMEX: 103028806(cpm)
TRU: 101065920(cpm)
LCO: 104931508(cpm)
NCC: 104965076
MZE: 101469424(cpm)
OLA: 101169896(cpm)
XMA: 102218156(cpm)
PRET: 103459312(cpm)
NFU: 107386863(cpm)
KMR: 108228768
CSEM: 103382529(cpm)
SDU: 111224538(cpm)
HCQ: 109532598(cpm)
BPEC: 110161911(cpm)
MALB: 109952968(cpm)
SASA: 106576655
OTW: 112240098
ELS: 105017802(cpm)
SFM: 108936551(cpm)
LCM: 102355516(CPM)
CMK: 103184619 103185307(cpm)
APLC: 110991093
TCA: 100142054
TUT: 107360791
MYI: 110464022
OBI: 106873734
LAK: 106170216
EGL: EGR_02374
 » show all
Taxonomy
Reference
1  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6
Reference
2  [PMID:2775217]
  Authors
Deddish PA, Skidgel RA, Erdos EG.
  Title
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).
  Journal
Biochem J 261:289-91 (1989)
Reference
3  [PMID:2914904]
  Authors
Skidgel RA, Davis RM, Tan F.
  Title
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.
  Journal
J Biol Chem 264:2236-41 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.12
IUBMB Enzyme Nomenclature: 3.4.17.12
ExPASy - ENZYME nomenclature database: 3.4.17.12
BRENDA, the Enzyme Database: 3.4.17.12
CAS: 120038-28-0

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