KEGG   ENZYME: 3.4.17.14Help
Entry
EC 3.4.17.14                Enzyme                                 

Name
zinc D-Ala-D-Ala carboxypeptidase;
Zn2+ G peptidase, D-alanyl-D-alanine hydrolase;
D-alanyl-D-alanine-cleaving carboxypeptidase;
DD-carboxypeptidase;
G enzyme;
DD-carboxypeptidase-transpeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl!D-alanine
Comment
A zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism. Weakly inhibited by beta-lactams. In peptidase family M15. Distinct from EC 3.4.16.4, serine-type D-Ala-D-Ala carboxypeptidase.
History
EC 3.4.17.14 created 1992
Pathway
ec00550  Peptidoglycan biosynthesis
Orthology
K07260  zinc D-Ala-D-Ala carboxypeptidase
K08640  zinc D-Ala-D-Ala carboxypeptidase
K18866  zinc D-Ala-D-Ala dipeptidase/carboxypeptidase
Genes
RAH: Rahaq_0795
RAQ: Rahaq2_0842
RAA: Q7S_03725
ROX: BV494_20860
XFA: XF_0881
XFT: PD_1799
XFM: Xfasm12_1968
XFN: XfasM23_1902
XFF: XFLM_03420
XFL: P303_10370
XCC: XCC1132
XCB: XC_3111
XCP: XCR_1357
XCV: XCV1265
XAX: XACM_1208
XAC: XAC1233
XCI: XCAW_03120(vanY)
XOO: XOO3523(VanY)
XOM: XOO3329(XOO3329)
XOP: PXO_04455
XOR: XOC_1299
XAL: XALC_0901
XPH: XppCFBP6546_05320(XppCFBP6546P_05320)
SML: Smlt1259
SMT: Smal_1102
SMZ: SMD_1174
PSUW: WQ53_02720
PSD: DSC_06135
LEZ: GLE_1584(dacA)
LEM: LEN_3378
DKO: I596_2231
FTU: FTT_0549(vanY)
FTQ: RO31_0625
FTF: FTF0549(vanY)
FTW: FTW_0992
FTT: FTV_0512(vanY)
FTG: FTU_0596(vanY)
FTL: FTL_1004
FTH: FTH_0981(vanY)
FTA: FTA_1058
FTS: F92_05550
FTI: FTS_0982(vanY)
FTC: DA46_1798
FTV: CH67_1345
FTZ: CH68_1077
FTM: FTM_1136(vanY)
FTN: FTN_0967(vanY)
FTX: AW25_1045
FTD: AS84_1562
FPH: Fphi_1633
FPT: BZ13_357
FPI: BF30_1908
FPM: LA56_532
FPX: KU46_1667
FPZ: LA55_1153
FPJ: LA02_1329
FNA: OOM_1029
HAR: HEAR1716
MMS: mma_1576
MXA: MXAN_3402
STAX: MC45_09455
BSU: BSU19620(yodJ)
BSR: I33_2202
BSL: A7A1_2833
BSH: BSU6051_19620(yodJ)
BSUT: BSUB_02111(yodJ)
BSUL: BSUA_02111(yodJ)
BSUS: Q433_11665
BSS: BSUW23_10485(yodJ)
BST: GYO_2367
BSO: BSNT_08530(yodJ)
BSQ: B657_19620(yodJ)
BSX: C663_2017(yodJ)
BLI: BL01438(yodJ)
BLD: BLi02284(yodJ)
BLH: BaLi_c23670(yodJ)
BAY: RBAM_019410(yodJ)
BAQ: BACAU_1942(yodJ)
BYA: BANAU_2065(yodJ)
BAMP: B938_10060
BAML: BAM5036_1873(yodJ)
BAMA: RBAU_1911(yodJ)
BAMN: BASU_1892(yodJ)
BAMB: BAPNAU_1804(yodJ)
BAMT: AJ82_11025
BAMY: V529_19740(yodJ)
BMP: NG74_02021(vanYB)
BAO: BAMF_2037(yodJ)
BAZ: BAMTA208_07320(yodJ)
BQL: LL3_02140(yodJ)
BXH: BAXH7_01488(yodJ)
BQY: MUS_2319(yodJ)
BAMI: KSO_009640
BAMC: U471_20030
BAMF: U722_10590
BATR: TD68_07695
BHA: BH1810
BCZ: BCE33L2266 BCE33L4261(dacF) BCE33L4603(vanY)
BCQ: BCQ_4322(dacF) BCQ_4665(vanY)
BAL: BACI_c24940(dacA3) BACI_c45060(dacF) BACI_c48540(vanY1)
BTK: BT9727_2308(dacA) BT9727_4249(dacF) BT9727_4581(vanY)
BTL: BALH_2271 BALH_4098(dacF) BALH_4414(vanY)
BTG: BTB_c33410(vanYB) BTB_c35950(yodJ2) BTB_c46620(yodJ3) BTB_c50080(vanY)
BWW: bwei_0033(vanY) bwei_0383(dacF3) bwei_1528(dacA4) bwei_1775(vanYB) bwei_5334(dacA3)
BCL: ABC0801
BPU: BPUM_1883
BPUS: UP12_09630
BCK: BCO26_1257(yodJ)
BAG: Bcoa_3273
BCOA: BF29_281
BJS: MY9_2147
BMET: BMMGA3_10075(yodJ)
BACW: QR42_09580
BACP: SB24_18985
BACB: OY17_12840
BACO: OXB_0490
BACY: QF06_08940
BACL: BS34A_21750(yodJ)
BALM: BsLM_2085
BGY: BGLY_2535
BBEV: BBEV_3208(yodJ)
OIH: OB0530
GKA: GK1581
GTN: GTNG_1428
GGH: GHH_c15980(yodJ)
GEA: GARCT_01588(vanYB)
AFL: Aflv_1383
ANM: GFC28_594
AAMY: GFC30_1875
AXL: AXY_18480
LSP: Bsph_4320
HHD: HBHAL_2179(yodJ)
VPN: A21D_00712(vanY) A21D_01439(vanYB)
BSE: Bsel_0152
SEP: SE0034
SHA: SH0186
SHH: ShL2_00111(vanY)
SSP: SSP0884
SCA: SCA_1643
SPAS: STP1_1247
MCAK: MCCS_00910(vanY_1) MCCS_21000(vanY_2) MCCS_21010(vanYB)
LMO: lmo1855
LMOE: BN418_2232
LMOB: BN419_2234
LMOD: LMON_1923
LMOW: AX10_03510
LMOQ: LM6179_2625(yodJ)
LMR: LMR479A_1965(yodJ)
LMOM: IJ09_00555
LMOG: BN389_18800(yodJ)
LMP: MUO_09520
LMOX: AX24_07040
LMQ: LMM7_1949(vanY)
LMS: LMLG_2097
LMOK: CQ02_09625
LIN: lin1969
LWE: lwe1874
LSG: lse_1835
LIV: LIV_1831
ESI: Exig_1148
PPM: PPSC2_02955(yodJ)
PPO: PPM_0534(yodJ)
PPOL: X809_02420
PPQ: PPSQR21_005690(vanY)
PPOY: RE92_08980
PMW: B2K_33145
PRI: PRIO_3416(vanY) PRIO_6384
PSWU: SY83_09610
ASOC: CB4_01291(vanYB)
JEO: JMA_07930
KUR: ASO14_286
LLA: L175147(dacB)
LLK: LLKF_0979(dacB)
LLT: CVCAS_0916(dacB)
LLS: lilo_0899(dacB)
LLX: NCDO2118_1015(dacB)
LLC: LACR_1023
LLM: llmg_1578(dacB)
LLR: llh_7875
LLI: uc509_0992(dacB)
LLW: kw2_0945
LLJ: LG36_1374(dacB)
LGR: LCGT_0418
LGV: LCGL_0418
SPY: SPy_1765
SPYA: A20_1551c(dacB)
SPS: SPs0331
SPF: SpyM50343
STG: MGAS15252_1348(vanY)
STX: MGAS1882_1409(vanY)
SPYH: L897_07250
SPN: SP_0629
SPD: SPD_0549
SPR: spr0554
SPW: SPCG_0590
SJJ: SPJ_0581
SPX: SPG_0573
SNT: SPT_0654
SND: MYY_0678
SPNN: T308_02970
SPV: SPH_0722
SPP: SPP_0646
SNP: SPAP_0615
SAG: SAG0093
SAN: gbs0092
SAK: SAK_0143
SGC: A964_0096
SAGM: BSA_1450
SAGI: MSA_1560
SAGR: SAIL_1520
SAGP: V193_01525
SAGC: DN94_01525
SAGE: EN72_00735
SAGG: EN73_00710
SAGN: W903_0150
SMU: SMU_75
SMUA: SMUFR_0063
STC: str0116(dacB)
STL: stu0116(dacB)
STE: STER_0159
STN: STND_0117
STU: STH8232_0186(dacB)
STW: Y1U_C0106
STHE: T303_01830
SSI: SSU0698
SUP: YYK_03330
SSUY: YB51_4385
SSUT: TL13_1056
SSUI: T15_1263
SEZ: Sez_0398
SEQ: SZO_15820
SEZO: SeseC_00468(vanY)
SEQU: Q426_07305
SEU: SEQ_0470
SUB: SUB1508
SDS: SDEG_1832
SDA: GGS_1649
SDC: SDSE_1913
SGT: SGGB_0312(vanY)
SMB: smi_1571(vanYb)
SOR: SOR_1465
STB: SGPB_0233(vanY)
SSAH: HSISS4_00093(dacB) HSISS4_00381(cbpD3)
SMN: SMA_0279(vanYB)
SIF: Sinf_0266
SIE: SCIM_1344
SLU: KE3_0229
STRN: SNAG_1428(vanYB)
LPL: lp_1010(dacB)
LPJ: JDM1_0836(dacB)
LPT: zj316_1060(dacB)
LPS: LPST_C0811(dacB)
LPZ: Lp16_0817
EFA: EF2297(vanYB)
EFL: EF62_2955(pbp5)
EFI: OG1RF_12161(vanYB)
EFS: EFS1_2266
EFQ: DR75_1552
ENE: ENT_19710
EFM: M7W_1692
EHR: EHR_13010
EDU: LIU_06945
THL: TEH_15410
OOE: OEOE_1065
LME: LEUM_0292
LMM: MI1_01205
LMK: LMES_0235
LCI: LCK_01506(dacB)
LKI: LKI_06970
LGS: LEGAS_0373(dacB)
WKO: WKK_00495
WCE: WS08_1128
WCT: WS74_1196
CRN: CAR_c16530(yodJ)
CML: BN424_840
CARC: NY10_1039
JDA: BW727_100055(vanYB)
CAC: CA_C3297
CAE: SMB_G3334(yodJ)
CAY: CEA_G3299
CPE: CPE1379
CPF: CPF_1631
CPR: CPR_1371
CBK: CLL_A1481
CBE: Cbei_3664
CBZ: Cbs_3664
CBEI: LF65_04130
CLT: CM240_2504(dacF)
CBV: U729_2163
AMT: Amet_3325
CTH: Cthe_1899
CSS: Cst_c10790(vanXY) Cst_c10800(yodJ)
ESR: ES1_00250
CCEL: CCDG5_1882
RUS: RBI_I00503(vanY1) RBI_I00532(vanY2) RBI_I01028(vanY) RBI_II00351(vanY3) RBI_II00378
FPR: FP2_12250
BPB: bpr_I1333(vanY)
BHU: bhn_I1469
RIX: RO1_43140
CCT: CC1_18700
ROB: CK5_34960
CSO: CLS_04650
BPRL: CL2_18730
HSD: SD1D_2332
CPRO: CPRO_11600(vanYB)
ERT: EUR_06540
PDC: CDIF630_01804(vanY1) CDIF630_02753(vanY2) CDIF630_03923(vanY3)
STH: STH1075
AWO: Awo_c10790(dacB2) Awo_c26840
OVA: OBV_09500
TOC: Toce_0645
FMA: FMG_1136
APR: Apre_0495
PMIC: NW74_02100
CAD: Curi_c05070(vanXY)
ERH: ERH_0151
SCO: SCO5467(SC2A11.01)
SGB: WQO_23270
SCB: SCAB_6441
SFA: Sfla_2066
SALB: XNR_1349
SALS: SLNWT_3445
STRP: F750_4755
SFI: SFUL_4879
SPRI: SPRI_2650
SLE: sle_06160(sle_06160)
STRD: NI25_11895
SMAL: SMALA_8140
SLAU: SLA_6541
MTS: MTES_1148
AUW: AURUGA1_00074(vanYB)
ART: Arth_2914
ARR: ARUE_c30530(yodJ1) ARUE_c38230(yodJ2)
ACH: Achl_2623
KRH: KRH_15330(dac)
LMOI: VV02_22535
XCE: Xcel_1721
IDO: I598_2723(vanYB_2)
CFL: Cfla_2914
KFL: Kfla_6273
MMAR: MODMU_1060
KRA: Krad_1388
SEN: SACE_6065
AMD: AMED_3620
AOI: AORI_3718
SESP: BN6_60940
ACTI: UA75_26070
ACAD: UA74_25490
MIL: ML5_1374
ASE: ACPL_278
ACTN: L083_3523
AFS: AFR_15495
ACTS: ACWT_0163
BBI: BBIF_0993
BBP: BBPR_1048(vanYG)
BBF: BBB_0974(vanYB)
BSCA: BBSC_1356
RXY: Rxyl_2970
CWO: Cwoe_4758
AEQ: AEQU_0398
SYN: sll0034
SYY: SYNGTS_2834(sll0034)
SYT: SYNGTI_2833(sll0034)
SYS: SYNPCCN_2832(sll0034)
SYQ: SYNPCCP_2832(sll0034)
SYW: SYNW1098
SYC: syc2418_c(vanY)
SYG: sync_1283
CYA: CYA_0671
CYB: CYB_1058
SYNR: KR49_02785
SYND: KR52_10475
TEL: tll0932
THN: NK55_11230(dacC)
LET: O77CONTIG1_01333(vanYB_1) O77CONTIG1_02974(vanYB_2)
HHG: XM38_005750(yodJ_1) XM38_009000(yodJ_2)
PMA: Pro_0833(vanY)
PMM: PMM0761
PMT: PMT_0576
PMB: A9601_08231(vanY)
PMC: P9515_08221(vanY)
PMF: P9303_16751(vanY)
PMH: P9215_08551(vanY)
PMJ: P9211_10021(vanY)
PRC: EW14_0850
PRM: EW15_0846
AMR: AM1_0151
MAR: MAE_07870
MPK: VL20_198
CYL: AA637_01985(vanY) AA637_03050(vanY-2) AA637_03055
CYT: cce_3005
TER: Tery_4445
GVI: glr2377
GLJ: GKIL_4422
ANA: all3702
AVA: Ava_3580
NAZ: Aazo_3932
NSP: BMF81_01489(vanY)
CTHE: Chro_1346
CEO: ETSB_0314
TRA: Trad_0869
OBG: Verru16b_01762(vanYB)
BBU: BB_0582
BBUR: L144_02850
BGA: BG0594
BGB: KK9_0606
BGN: BgCN_0600
BAFT: P612_02980
BAFE: BAFK78_584
BCHI: OY14_02885
BTU: BT0582
BHR: BH0582
BDU: BDU_585
BRE: BRE_588
BCW: Q7M_590
BMIY: RJ61_02840
BPAK: X966_02945
BANE: N187_02855
TPA: TP_0221
TPW: TPANIC_0221(vanY)
TPU: TPADAL_0221(vanY)
TPO: TPAMA_0221(vanY)
TPC: TPECDC2_0221(vanY)
TPG: TPEGAU_0221(vanY)
TPM: TPESAMD_0221(vanY)
TPB: TPFB_0221(vanY)
TDE: TDE0633
TPL: TPCCA_0221(vanY)
TPED: TPE_0739
FLM: MY04_0758
 » show all
Taxonomy
Reference
1  [PMID:7121588]
  Authors
Dideberg O, Charlier P, Dive G, Joris B, Frere JM, Ghuysen JM.
  Title
Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution.
  Journal
Nature 299:469-70 (1982)
  Sequence
[salb:XNR_1349]
Reference
2  [PMID:6825689]
  Authors
Joris B, Van Beeumen J, Casagrande F, Gerday C, Frere JM, Ghuysen JM.
  Title
The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G.
  Journal
Eur J Biochem 130:53-69 (1983)
DOI:10.1111/j.1432-1033.1983.tb07116.x
  Sequence
[salb:XNR_1349]
Reference
3  [PMID:6597561]
  Authors
Ghuysen JM, Frere JM, Leyh-Bouille M, Nguyen-Disteche M, Coyette J, Dusart J, Joris B, Duez C, Dideberg O, Charlier P, et al.
  Title
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.
  Journal
Scand J Infect Dis Suppl 42:17-37 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.14
IUBMB Enzyme Nomenclature: 3.4.17.14
ExPASy - ENZYME nomenclature database: 3.4.17.14
BRENDA, the Enzyme Database: 3.4.17.14
CAS: 213189-85-6

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