KEGG   ENZYME: 3.4.17.21
Entry
EC 3.4.17.21                Enzyme                                 
Name
glutamate carboxypeptidase II;
N-acetylated-gamma-linked-acidic dipeptidase (NAALADase);
folate hydrolase;
prostate-specific membrane antigen;
pteroylpoly-gamma-glutamate carboxypeptidase;
microsomal gamma-glutamyl carboxypeptidase;
pteroylpolyglutamate hydrolase;
folylpolyglutamate hydrolase;
pteroylpoly-gamma-glutamate hydrolase;
pteroylpolygammaglutamyl hydrolase;
pteroylpolyglutamic acid hydrolase;
PSM antigen;
acetylaspartylglutamate dipeptidase;
NAALA dipeptidase;
rat NAAG peptidase;
mGCP;
membrane glutamate carboxypeptidase;
N-acetylated-alpha-linked-amino dipeptidase;
prostrate-specific membrane antigen;
N-Acetylated alpha-linked acidic dipeptidase;
PSMA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates [RN:R10687]
Reaction(KEGG)
R10687;
(other) R10688
Comment
A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa , but also exists in a soluble form. Hydrolyses alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu, and folylpoly-gamma-glutamates. With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate [4]. Does not hydrolyse Ac-beta-Asp-Glu. Known inhibitors: quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (folate gamma-glutamyl hydrolase).
History
EC 3.4.17.21 created 1997, modified 2000 (EC 3.4.13.8 created 1972 and EC 3.4.19.8 created 1992, incorporated 2000)
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K01301  N-acetylated-alpha-linked acidic dipeptidase
K14592  glutamate carboxypeptidase II (folate hydrolase 1)
Genes
HSA10003(NAALAD2) 10004(NAALADL1) 2346(FOLH1) 254827(NAALADL2)
PTR451185 451309(NAALADL1) 451475(FOLH1B) 451478(NAALAD2) 745481(NAALADL2)
PPS100970655(NAALAD2) 100970744(NAALADL1) 100970802 100980316 100991481(NAALADL2)
GGO101124045(NAALAD2) 101133710(NAALADL1) 101136594(NAALADL2) 101147888 101149915
PON100445995(NAALADL1) 100453848(FOLH1B) 100460916(NAALAD2) 103890310(NAALADL2)
NLE100579763(NAALADL1) 100582294(NAALAD2) 100582881(NAALADL2) 100589099(FOLH1B)
MCC694180(NAALAD2) 707714(FOLH1B) 717018(NAALADL1) 721738(NAALADL2)
MCF101866140(FOLH1B) 101926468(NAALAD2) 102124059(NAALADL1) 102146742(NAALADL2)
CSAB103221229(NAALADL2) 103231779(NAALADL1) 103248197(FOLH1B) 103248216(NAALAD2)
CATY105577461(NAALADL1) 105592968(FOLH1B) 105596302(NAALADL2)
PANU100999383(NAALADL1) 101011150(NAALADL2) 101022396
TGE112605634(NAALADL1) 112606075(FOLH1B) 112606266(NAALAD2) 112619668(NAALADL2)
RRO104660791(NAALADL2) 104662834(NAALADL1) 104672807(NAALAD2) 104678909(FOLH1B)
RBB108512432(NAALADL2) 108519803(NAALAD2) 108539153(FOLH1B) 108543140(NAALADL1)
TFN117080629(FOLH1B) 117081211(NAALADL1) 117081227(NAALAD2) 117083747(NAALADL2)
PTEH111521418(NAALADL2) 111522470(NAALADL1) 111540742(NAALAD2) 111540744(FOLH1B)
CJC100393124(NAALADL2) 100396945(FOLH1B) 100406630(NAALAD2) 100413235(NAALADL1)
SBQ101032246(NAALADL1) 101032598(NAALADL2) 101033656(NAALAD2) 101044541(FOLH1B)
CSYR103269512(NAALADL2) 103271403(NAALAD2) 103271409 103275605(NAALADL1)
MMUR105856200(NAALAD2) 105862399(NAALADL2) 105865102 105865103 105878502(NAALADL1)
LCAT123630274(NAALADL2) 123641394(NAALADL1) 123642233(NAALAD2) 123642235(FOLH1B)
OGA100947383(NAALADL1) 100955882(NAALADL2) 100960933(NAALAD2) 100962089(FOLH1B)
MMU381204(Naaladl1) 53320(Folh1) 635702(Naaladl2) 72560(Naalad2)
MCAL110285942(Naaladl1) 110291664(Naaladl2) 110297451(Folh1b) 110301515(Naalad2)
MPAH110320238(Naaladl2) 110325375(Folh1b) 110327617(Naalad2) 110333953(Naaladl1)
RNO300384(Naalad2) 499583(Naaladl2) 83568(Naaladl1) 85309(Folh1)
MCOC116073016(Naalad2) 116095001(Naaladl2) 116100637(Folh1b) 116103437(Naaladl1)
MUN110541628 110549375(Naaladl1) 110562303
CGE100761363(Naaladl2) 100768106(Naaladl1) 100768684 100769032
MAUA101828054(Naalad2) 101836483(Naaladl1) 101841671(Folh1b) 101843922(Naaladl2)
PLEU114682103(Naaladl1) 114682738(Folh1b) 114684212 114697548(Naaladl2) 114706218
MORG121444201(Folh1b) 121451818(Naalad2) 121452859(Naaladl2) 121454289(Naaladl1)
AAMP119802635(Folh1b) 119810111(Naalad2) 119822592(Naaladl1) 119826137(Naaladl2)
NGI103728962(Naaladl2) 103737918(Naalad2) 103738766(Naaladl1) 103750517(Folh1)
HGL101702083(Naaladl1) 101707025(Naaladl2) 101722660(Naalad2) 101725016(Folh1b)
CPOC100712916(Folh1b) 100719214(Naaladl2) 100724644(Naaladl1) 100726280
CCAN109687101(Naaladl1) 109696834 109699708(Naalad2)
DORD105985569(Naaladl2) 105989042(Naaladl1) 105997618(Naalad2) 106000547(Folh1b)
DSP122104895(Naaladl1) 122107294(Naaladl2) 122112455(Naalad2) 122115932(Folh1b)
NCAR124958502 124960251 124960335 124992883
OCU100339446(NAALAD2) 100342215(NAALADL2) 100358060(FOLH1) 103346158(NAALADL1)
OPI101520191(FOLH1B) 101521412(NAALADL2) 101522630(NAALAD2) 101531216(NAALADL1)
TUP102475075(NAALADL1) 102486443 102487205(FOLH1B) 102488479(NAALAD2) 102499204(NAALADL2)
CFA476775(FOLH1) 483751(NAALADL1) 485139(NAALAD2) 488174(NAALADL2)
VVP112915749 112915751(NAALAD2) 112924284(NAALADL1) 112926681(NAALADL2)
VLG121471334(NAALADL1) 121476403 121476478 121477597(NAALADL2) 121491882
AML100469236(NAALAD2) 100470423(NAALADL1) 100472805 100482558(NAALADL2)
UMR103660690(NAALAD2) 103675371(FOLH1B) 103676133(NAALADL2) 103679566(NAALADL1)
UAH113244140(NAALADL1) 113254934(NAALADL2) 113259841(NAALAD2) 113269424(FOLH1B)
UAR123778289(NAALADL1) 123786402(NAALADL2) 123787840(NAALAD2) 123803814
ELK111148153 111149781 111154474 111154494
LLV125078679 125078783 125079178 125100528
MPUF101670699(NAALADL1) 101679271(NAALADL2) 101694251(FOLH1B) 101694539(NAALAD2)
ORO101364747(NAALADL1) 101366533 101375024(NAALADL2)
EJU114199711(FOLH1B) 114200888(NAALAD2) 114207059(NAALADL2) 114220515(NAALADL1)
ZCA113913704(FOLH1B) 113913811(NAALAD2) 113915287(NAALADL1) 113918667(NAALADL2)
MLX117999584(NAALADL2) 118013455(NAALAD2) 118013456(FOLH1B) 118016023(NAALADL1)
FCA101082777(NAALADL1) 101089389(NAALAD2) 101089641(FOLH1B) 101098650(NAALADL2)
PYU121023762(NAALADL1) 121034005(NAALADL2) 121039399(FOLH1B) 121039401(NAALAD2)
PBG122483222(NAALAD2) 122483225(FOLH1B) 122483991(NAALADL1) 122491719(NAALADL2)
PTG102953631(NAALADL1) 102957765(FOLH1B) 102958523(NAALAD2) 102970620(NAALADL2)
PPAD109246699 109267331(FOLH1B) 109267336(NAALAD2) 109275146(NAALADL2)
AJU106971153(NAALADL1) 106973866(NAALADL2) 106983063(FOLH1B) 106983075(NAALAD2)
HHV120240225(NAALADL1) 120246246(FOLH1B) 120246593(NAALAD2) 120248367(NAALADL2)
BTA100337356(NAALADL2) 505865(FOLH1B) 506692(NAALADL1) 536439(NAALAD2)
BOM102265480(NAALAD2) 102272952(FOLH1B) 102284550 102286181(NAALADL1) 106700854
BIU109554530(NAALADL1) 109554596(FOLH1B) 109554645(NAALAD2) 109557961(NAALADL2)
BBUB102403110(NAALAD2) 102406997(FOLH1B) 102410599(NAALADL1) 102413544(NAALADL2)
CHX102170637(NAALADL2) 102177776(NAALAD2) 102186842(NAALADL1) 102190665(FOLH1B)
OAS101105198(NAALADL1) 101111764 101120451(NAALAD2) 101121723
ODA120869819(NAALADL2) 120874639(NAALADL1) 120874814(NAALAD2) 120874817(FOLH1B)
CCAD122431233(NAALADL1) 122431236(NAALAD2) 122431256(FOLH1B) 122444921(NAALADL2)
SSC100515250(NAALADL1) 100522279(NAALADL2) 100524386(NAALAD2) 397677(FOLH1B)
CFR102510657(FOLH1B) 102511847(NAALADL2) 102519706(NAALADL1) 102520257
CBAI105063307(NAALADL2) 105070662(NAALADL1) 105083512(NAALAD2) 105083514(FOLH1B)
CDK105085936(NAALADL2) 105088594(FOLH1B) 105088596(NAALAD2) 105102621(NAALADL1)
VPC102526685(NAALAD2) 102529966(NAALADL2) 102545019(FOLH1B) 102545929(NAALADL1)
BACU103001153 103002601(NAALAD2) 103019730(NAALADL1)
LVE103072597(NAALADL1) 103079394(NAALADL2) 103089873 103090789(NAALAD2)
OOR101273529(NAALADL2) 101281334 101283878(NAALADL1)
DLE111167972(NAALAD2) 111170975 111173893(NAALADL2) 111184088(NAALADL1)
PCAD102977025(NAALAD2) 102979651(FOLH1B) 102980184(NAALADL2) 102996597(NAALADL1)
PSIU116753423(NAALADL2) 116757543(NAALAD2) 116758197 116758414(NAALADL1)
ECB100050187(NAALAD2) 100056368(NAALADL1) 100060132(FOLH1B) 100064889(NAALADL2) 111771951 111772143
EPZ103547857(FOLH1B) 103552273(NAALADL2) 103558584(NAALAD2) 103559154(NAALADL1)
EAI106822677(FOLH1B) 106827519(NAALAD2) 106833668(NAALADL1) 106847520(NAALADL2)
MYB102246530(NAALADL1) 102253215(NAALADL2) 102258767(FOLH1B) 102262061(NAALAD2)
MYD102757107 102761189(FOLH1B) 102761368(NAALAD2) 102774994(NAALADL1)
MMYO118664532(NAALAD2) 118664536(FOLH1B) 118665334 118665512 118676222(NAALADL2)
MLF102419004(NAALADL2) 102419154(NAALADL1) 102420089 102427345(NAALAD2) 102429206
MNA107532373 107532446(NAALAD2) 107533579(NAALADL1) 107541091(NAALADL2)
PKL118712525(NAALAD2) 118712526(FOLH1B) 118714932(NAALADL1) 118722370(NAALADL2)
HAI109373422(NAALADL2) 109374031(NAALAD2) 109374041(FOLH1B) 109384301(NAALADL1)
DRO112300548(NAALAD2) 112307558(NAALADL2) 112315970(FOLH1B) 112317339(NAALADL1)
SHON118984699 118984760 118987388(NAALADL2) 118991701(NAALADL1)
AJM119036539(NAALADL2) 119044483 119050251(NAALADL1) 119061459(NAALAD2)
PDIC114490831(NAALADL2) 114499474(FOLH1B) 114499596(NAALAD2) 114500174(NAALADL1)
PHAS123805466(NAALAD2) 123805618(FOLH1B) 123826997(NAALADL2) 123829575(NAALADL1)
MMF118617297(NAALADL2) 118627580(FOLH1B) 118627944(NAALAD2) 118628176(NAALADL1)
RFQ117030156(NAALADL1) 117031190(FOLH1B) 117031308(NAALAD2) 117036081(NAALADL2)
PALE102888077(NAALADL2) 102893898(NAALADL1) 102895068 102895568
PGIG120590541(FOLH1B) 120590564(NAALAD2) 120600613(NAALADL1) 120604401(NAALADL2)
PVP105294194(FOLH1B) 105294196(NAALAD2) 105297996(NAALADL1) 105306048(NAALADL2)
RAY107497515(NAALADL1) 107514943(FOLH1B) 107514944(NAALAD2) 107516557(NAALADL2)
MJV108390597(FOLH1B) 108393713 108396384(NAALADL1) 108396602(NAALAD2)
TOD119230685 119249999(NAALADL1) 119258054
SARA101552787(NAALADL2) 101556016(NAALADL1) 101559350
LAV100660135(FOLH1B) 100664500(NAALADL1) 100677198(NAALAD2)
TMU101344241 101349859 101357352 101358124
DNM101432712(NAALADL1) 101438576 101441972(NAALADL2) 101445169
MDO100009990(FOLH1B) 100011662(NAALADL2) 100013563(NAALAD2) 100030670(NAALADL1)
GAS123238955(NAALAD2) 123240544(FOLH1B) 123242068(NAALADL2) 123256622(NAALADL1)
SHR100913549(NAALADL1) 100918727(FOLH1B) 100927408(NAALAD2) 100930261(NAALADL2)
PCW110195316(NAALADL1) 110204290(NAALADL2) 110213435(FOLH1B) 110218170(NAALAD2)
OAA100081512 100081595 100681223(NAALADL2)
GGA419010(NAALAD2) 419011(FOLH1) 429156(NAALADL2)
PCOC116241925 116241929 116243425(NAALADL2)
MGP100549526(NAALADL2) 100550377 100550530 100550836
CJO107308460 107308462 107318243(NAALADL2)
NMEL110390755 110390764 110398161(NAALADL2)
APLA101789505 101790444 101798312(NAALADL2)
ACYG106032006(NAALADL2) 106034162 106034164
AFUL116489852 116489875 116492519(NAALADL2)
TGU100219205(NAALADL2) 100223080 100225953
LSR110478412 110478414 110480366(NAALADL2)
SCAN103815300(NAALADL2) 103827252 103827253
PMOA120504427(NAALADL2) 120506649 120506650
OTC121336704(NAALADL2) 121340974 121341016(FOLH1B)
PRUF121353837(NAALADL2) 121362277 121362303
GFR102034713(NAALAD2) 102034877(FOLH1B) 102042454(NAALADL2)
FAB101814982(FOLH1) 101815312(NAALAD2) 101818062(NAALADL2)
PHI102104341(NAALADL2) 102105283(FOLH1B) 102106596(NAALAD2)
PMAJ107205820 107208885(NAALADL2) 107211745
CCAE111924890 111933596(NAALADL2)
CCW104688028(NAALADL2) 104690325(FOLH1B) 104690326
ETL114061783 114063504(FOLH1B) 114063505 114065093
ZAB102063122(NAALADL2) 102066126 102073115
FPG101911476(NAALADL2) 101915194(NAALAD2) 101918547
FCH102051438(NAALADL2) 102054726 102058819
CLV102092293(NAALADL2) 102094196 102095234
EGZ104126200(NAALADL2) 104128837 104128839
NNI104017353(NAALAD2) 104017386(FOLH1B) 104019607 104022073
PLET104613666 104621501
ACUN113476441 113476470 113483425(NAALADL2)
TALA104355464 104365430(NAALADL2) 104367404
PADL103914987 103924984 103926029 103926056
ACHC115347404(NAALADL2) 115353314 115353458
AAM106488115(NAALADL2) 106495495 106495541 106496844
AROW112963570(NAALADL2) 112973711(FOLH1B) 112973713
NPD112949987(NAALAD2) 112949989 112952383(NAALADL2)
DNE112986446(NAALADL2) 112988580 112988591
ASN102373311(NAALADL2) 102373839 102381492(NAALADL1) 102387337 102387587
AMJ102562464(NAALADL1) 102567523(NAALADL2) 102569346(FOLH1B) 106737083
CPOO109306784 109306785 109308447(NAALADL2) 109324415(NAALADL1)
GGN109287997(NAALADL2) 109302532 109302806(FOLH1B)
PSS102454431(NAALADL1) 102454607(NAALADL2) 102455710(FOLH1B) 102456275
CMY102930770(NAALADL2) 102933727 102934118 102942487(NAALADL1)
CPIC101933817 101934265(FOLH1B) 101939871(NAALADL1) 101948732(NAALADL2) 101952117
TST117871228 117871229(FOLH1B) 117880495(NAALADL1) 117882374
CABI116818085 116818087 116820159 116836260(NAALADL1)
MRV120372477(NAALADL2) 120383355 120389099(FOLH1B) 120409276(NAALADL1)
ACS100551729 100551830(naaladl1) 100552710(naaladl2) 100564848(naalad2)
PVT110087592 110090752
SUND121915063(NAALADL1) 121925779 121927293 121927306(NAALADL2)
PBI103052815 103055697 103056313(NAALADL2) 103058647
PMUR107290465 107295568 107295569 107298500(NAALADL1)
TSR106554598
PGUT117660097(FOLH1B) 117660188 117678175(NAALADL2)
VKO123025665(NAALADL2) 123029294 123029330 123032457(NAALADL1)
PMUA114586997(NAALADL1) 114595614(FOLH1B) 114595615 114597995(NAALADL2)
ZVI118076219(NAALADL1) 118084869 118085476(FOLH1B) 118094088(NAALADL2)
GJA107110076(NAALADL1) 107124069 107124070
STOW125430802 125432152 125437041(NAALADL1) 125437404(NAALADL2)
XLA100036903(naaladl1.L) 100037180 108707586 108709033(naalad2.S) 108717004(naaladl2.L) 734632(naalad2.L)
XTR100485577(folh1) 100487005 100487953(naaladl1) 100498087(naaladl2) 594947(naalad2)
NPR108785259(NAALADL1) 108794765(FOLH1B) 108794950(NAALADL2) 108795527 108802840
RTEM120917348(NAALADL1) 120920234 120928971 120928972 120936236 120936762(NAALADL2)
BBUF120980888(NAALADL1) 120981848 120996447 120996449 120997896(NAALADL2) 120999918
BGAR122920043(NAALADL1) 122922105 122922106 122924214 122932638 122932891(FOLH1B) 122936073(NAALADL2)
DRE100000223(naaladl1) 101885785 393247(naalad2)
SRX107744479(naaladl1) 107753869(naaladl2)
SANH107655960(naaladl2) 107673364(naaladl1) 107674503
SGH107558820 107568636 107595014 107600312
CCAR109078415(naaladl2) 109089106 109094362
CAUA113049412(naaladl1) 113055012 113083243 113110587 113110588
PPRM120468933 120469803(naaladl1) 120470719(naalad2)
MAMB125248580(naalad2) 125256188 125266699(naaladl1)
IPU108255540(naaladl1) 108255541 108271148 108277954(naalad2)
PHYP113526284(naaladl2) 113542655(naaladl1) 113544506(folh1b)
SMEO124380365(naaladl1) 124391299 124394672(naalad2)
TFD113637885(naalad2) 113638893(naaladl1) 113657924
AMEX103021590 103033129(naaladl1) 103041756(folh1b)
EEE113568958(naaladl2) 113578706(folh1b) 113583518(naaladl1)
TRU101065215(folh1b) 101077227(naaladl1) 105418700(naaladl2)
TNGGSTEN00020408G001 GSTEN00020410G001 GSTEN00029640G001
LCO104920121(folh1b) 104928492(naaladl1) 109137913(naaladl2)
NCC104950428(naaladl1)
CGOB115006630(naaladl2) 115013721(naaladl1) 115018252(folh1b)
ELY117252124(naaladl1) 117253790 117259288(naalad2)
PLEP121943610(naalad2) 121944226(naaladl1) 121962737
SLUC116048239(naalad2) 116053952(naaladl1) 116058719
ECRA117942334(naalad2) 117944913(naaladl1) 117950913
PFLV114551146(folh1b) 114556200(naaladl1)
GAT120827157(naalad2) 120830202(naaladl1)
PPUG119211254(naalad2) 119224968(naaladl1)
MSAM119883257(naalad2) 119892302(naaladl1) 119901248
CUD121510251(naaladl1) 121511708 121523818(naalad2)
ALAT119019600(naaladl1) 119028127 119034175(naalad2)
MZE101473097(naaladl1) 101476953 101487368(naaladl2) 112429880
ONL100693290(naaladl1) 100702164(folh1b) 102076038(naaladl2)
OAU116312314(naaladl1) 116314262 116323027(naalad2) 120436365
OLA101166965(naaladl1) 101170696(folh1b) 105353990
OML112148421(naaladl1) 112149875(naalad2) 112150722
XMA102216435(naaladl2) 102229486(naaladl1) 102230464(folh1b)
XCO114151151(naaladl2) 114154039(naaladl1) 114161841(folh1b)
XHE116707671(folh1b) 116726123(naaladl2) 116729221(naaladl1)
PRET103464027(naaladl2) 103469958(naaladl1) 103474484(folh1b)
PFOR103139813(naaladl2) 103142022(naaladl1) 103146267(folh1b)
PLAI106936567 106952238(naaladl2) 106957345(naaladl1) 106958870(folh1b)
PMEI106918016(folh1b) 106919909(naaladl2) 106925861(naaladl1)
GAF122827959(naaladl1) 122832952(naalad2) 122837974
CVG107085313(naaladl1) 107089929(naaladl2) 107091922(folh1b)
CTUL119771829(naalad2) 119797009(naaladl1)
GMU124873382 124878088(naaladl1) 124884603(naalad2)
NFU107380456(folh1b) 107387348(naaladl2) 107394320(naaladl1)
KMR108233753(naaladl1) 108244651(naalad2)
ALIM106517253(folh1b) 106519876(naaladl1)
NWH119411509(naalad2) 119413221(naaladl1)
AOCE111562694(naaladl2) 111564802(naaladl1) 111572656(folh1b)
CSEM103378545(folh1b) 103397950(naaladl1)
POV109625321(naaladl2) 109634582(folh1b) 109637042(naaladl1)
SSEN122769123(naaladl1) 122773343(naalad2) 122780425
HHIP117760528 117768088(naaladl1) 117772811(naalad2)
HSP118106349(naalad2) 124852360(naaladl1)
LCF108878813(naaladl2) 108881008(naaladl1) 108886619(folh1b)
SDU111224120(folh1b) 111237749(naaladl1)
SLAL111644635(naaladl1) 111655274(folh1b) 111671949(naaladl2)
XGL120790382 120792124(naalad2) 120804753(naaladl1)
HCQ109525183(naaladl1) 109525428(folh1b)
BPEC110154161 110154177 110154215 110174445(folh1b)
MALB109959081(naaladl1) 109971604(folh1b)
BSPL114853122 114863261(naaladl1) 114868572(naalad2)
SASA106570846(naaladl1) 106581411 106613925(naaladl2)
OTW112247991(naalad2) 112251038 112262525(naaladl1)
OMY110508008(naalad2) 110524461 110536434(naaladl1)
OGO123992549(naalad2) 123996922 124036636(naaladl1)
ONE115108450(naaladl2) 115119638(naaladl1)
SALP111975853(naaladl2) 112068932 112075199
SNH120036056(naalad2) 120063437(naaladl1)
ELS105021665(naaladl1) 105024062(folh1b) 105025892(naaladl2)
SFM108932227(folh1b) 108937262(naaladl2) 108939004(naaladl1)
PKI111833907(folh1b) 111850298(naaladl1) 111860531(naaladl2)
AANG118209276(naalad2) 118225400 118237422(naaladl1)
LOC102687412(folh1b) 102692081 102696163(naaladl1) 107079092(naaladl2)
PSPA121306591 121312646 121320350(naalad2) 121322539
ARUT117403488 117403805 117405436 117407325 117422025 117423232
LCM102346345(NAALADL1) 102361235 102366958(FOLH1B)
CMK103175760 103184309(naalad2)
RTP109917164 109921784 109922262(naaladl1) 109936345
BFO118408501 118409486 118409920 118412012 118415839 118415859 118416363 118418284 118419543 118425457 118431078
BBEL109463098 109464534 109469829 109471333 109472171 109473230 109474109 109484217 109485521 109486674 109487964 109487965 109488041
CIN100178697 100180761 494355
SCLV120326131 120326256 120335294 120335296 120335297 120336250 120336251 120341502 120341851
SPU100890803 576362 579656 583418 587160 756696 762877
APLC110979031 110979231 110979296 110979297 110983245
SKO100367154 100369295(NAALAD2)
BTAB109031844
DCI103513527
PHUPhum_PHUM452380
ZNE110836776
FCD110846916
DPXDAPPUDRAFT_315157 DAPPUDRAFT_315645 DAPPUDRAFT_315646
DMK116924614 116932392 116932393 116933055
PVM113803382 113803463 113805763 113808167 113828883
PJA122244884 122249167 122250623 122252066 122259034 122265485 122268192
PCHN125029877 125034303 125037494 125037978 125040378 125044036 125044660
HAME121853878 121854318 121854874 121866512 121867322 121869308 121870175
PCLA123752097 123765218 123769093 123771156 123771157 123774175
PTRU123498753 123499710 123505365 123506840 123508856 123510286 123512401
HAZT108667057 108670508 108676930 108677117
EAF111699976
LSM121125128 121125171 121125179 121126588
PPOI119097391 119099211 119103388
ISCIscW_ISCW005069 IscW_ISCW007773 IscW_ISCW014273 IscW_ISCW022413 IscW_ISCW022417 IscW_ISCW022420
DSV119431668 119431669 119432039 119445595 119446373 119455645 119457813 119458315 119459000 119464386
RSAN119373768 119374961 119389585 119390527 119401305 119402538 119403212 119404460
RMP119163973 119166833 119167403 119181141 119185195
VDE111251449 111253475 111254558
VJA111258992 111262566
TUT107366146
DPTE113794584 113799260
DFR124491053 124493102
CSCU111620947 111623650 111627457 111634107 111635827 111641185
PTEP107446485
SDM118203160
CELCELE_R57.1(gcp-2.1)
CBRCBG_00524 CBG_08178
BMYBM_BM2613(Bma-gcp-2.1)
LOALOAG_08413 LOAG_18605
NAINECAME_06124 NECAME_11666
HROHELRODRAFT_185132
LGILOTGIDRAFT_185795
PCAN112553655 112554364 112555054 112556705 112558664 112570360
BGT106066523 106071981 106072574 106079826
GAE121372287 121383708 121384191 121384810 121390370
HRF124113933 124113955 124119036 124121394 124121395 124121402 124121403 124129179 124130421 124140940 124140941 124140945 124140946 124140948 124140950 124142882 124143186 124143187 124144027 124152873
HRJ124253314 124261738 124262084 124267078 124267079 124275188 124276111 124276112 124277261 124278667
CRG105319337 105328683 105330787 105344131 105344132 105349101 117689395 117689399
MYI110442040 110442043 110448113 110448114 110448484 110449416 110457058
PMAX117322613 117323358 117324237 117327025 117336142 117342788 117345143
MMER123527538 123541008 123541017 123543841 123544868 123555773
OBI106867954 106868354
OSN115216731 115218023 115219722
LAK106155561 106156683 106156715 106163514 106165532 106166243 106169968 106171407 106171410
SMMSmp_135510
SHXMS3_0012459
OVIT265_00834
EGLEGR_00432
NVE5498904 5505695 5509032 5512449 5513501 5514520 5514909 5515632 5518380 5521144 5521258
EPA110231479 110233909 110235355 110239216 110241207 110241662 110243253 110246355 110246372 110248135
ATEN116287417 116289455 116292985 116296541 116296550 116296559 116296705 116297040 116299244 116299245 116299362 116300231 116303464 116303584 116304238 116305801 116309041
ADF107328731 107332396 107338868 107338872 107338896 107347938 107356895 107357177 107357379
AMIL114948098 114956455 114956456 114964731 114964748 114964762 114976576
PDAM113665800 113672961 113677028 113677034 113677813 113677822 113679020 113681369 113681657 113683120 113683786 113683790
SPIS111321324 111321344 111321359 111322624 111322765 111327581 111334480 111344828 111344829
DGT114520003 114530886 114530924 114530997
XEN124438437 124438439 124439058 124441709
HMG100200379 100207461 100209148 101234710 101240094
TADTRIADDRAFT_32203
AQU100631758 100639227
ATHAT3G54720(AMP1) AT4G07670 AT5G19740
ALY9307973 9312335
CRB17881914 17887087
CSAT104706311 104712075 104770346 104781339 104791744
EUSEUTSA_v10010161mg EUTSA_v10012881mg
BRP103841374 103846201 103863211
BNA106371788 106380741 106393988 106411714 106411900 106439461 106445485 106447965
BOE106307233 106317964 106326952 106337399 106338639
RSZ108817269 108830228 108863472
THJ104811076 104825265
CPAP110806397
CIT102618820 102631235
CICCICLE_v10007621mg CICLE_v10011190mg
PVY116130554 116130555 116142297 116142329
MINC123193824 123194271 123215482 123227166
TCC18588497 18599214
GRA105773579 105790252
GHI107901163 107934001 107954024 107962711
GAB108454028 108486145
DZI111286018 111296428 111299129 111311620
EGR104425550 104438213
GMX100797366 100798131 100817485 100818733
GSJ114369862 114399342 114407301 114407598
PVUPHAVU_001G199600g PHAVU_007G264800g
VRA106757990 106772721 106775461
VAR108324403 108329250 108346074
VUN114180371 114190050 114194501
CCAJ109796575 109804515 109818669
APRC113862887 113867562 113871390
MTRMTR_6g088825 MTR_7g107100
CAM101489280 101510982
LJALj1g3v4763600.1(Lj1g3v4763600.1) Lj1g3v4763600.2(Lj1g3v4763600.2) Lj2g3v0878750.2(Lj2g3v0878750.2) Lj2g3v0878930.1(Lj2g3v0878930.1) Lj2g3v0878930.2(Lj2g3v0878930.2) Lj2g3v0889190.1(Lj2g3v0889190.1) Lj2g3v0889190.2(Lj2g3v0889190.2)
ADU107490330 107492714
AIP107605532 107644444
AHF112695913 112735054 112751285 112755955 112802066
LANG109334865
FVE101292331 101298823 101310819
RCN112189968 112193091
PPER18769803 18769849
PMUM103339585 103340806
PAVI110748827 110751062
PDUL117634408 117634614
MDM103406790 103423230 103426730 103453796
PXB103942845 103965097 103968071
ZJU107405394 107432285 107432783 107432834
MNT21395638
CSV101221361
CMO103486721
BHJ120091571
MCHA111014512 111019318
CMAX111498787
CMOS111446753
CPEP111800317
RCU8259811 8265138
JCU105637832 105648976
HBR110638843 110647801
MESC110611888 110621717
POP7469920 7497629
PEU105112997 105138189
PALZ118047981 118049890
JRE108979117 109011903 109013488
QSU112002758 112019155 112032671 112039273
QLO115951385 115975622
TWL119997129 119998468
VVI100247495 100247933 100255555 100852933
VRI117920965 117925170
SLY101258817 101265621
SPEN107004743 107007633
SOT102599956 102606327
CANN107847784
NTA107776443 107776458 107790202 107811097
NSY104216513 104226176
NTO104088669 104114872
NAU109228816 109242961
INI109150451 109171149 109182261
ITR116006293 116020095 116030293
SIND105161797 105173559
OEU111367224 111399423
EGT105956832 105969297
SSPL121749520 121765291 121787202 121796307
HAN110868484 110928516
ECAD122600341 122600342 122600871 122603777
LSV111883847 111899797
CCAV112500216 112506081
DCR108213004 108213006 108218457
CSIN114287881 114314584
BVG104889147
SOE110776101
CQI110685988 110720488
NNU104590457 104592036
MING122057841 122076126
TSS122651850 122655798
PSOM113310840 113317114 113322521 113340047
NCOL116246689 116247364
OSA4326550 4327207 4327208 4334380
DOSAOs01t0740500-00(Os01g0740500) Os01t0740650-00(Os01g0740650) Os01t0743300-01(Os01g0743300) Os03t0790600-01(Os03g0790600)
OBR102704688 102706905 102707181 102708289 102710921
BDI100822748 100823266 100823514 100825924
ATS109757082 109765341 109767415 109775216 109775219
TDC119268881 119268896 119268897 119276838 119276852 119276853 119303470 119312126
TAES123061944 123061959 123061961 123070639 123070654 123070655 123079053 123079055 123079069 123079070 123105338 123113604 123123128
TUA125510894 125527384 125544636 125544649 125544650
SBI8062167 8075557 8084129
ZMA100147738 100280068 100280279 100280900
SITA101756601 101758809 101785000 101785670
SVS117838278 117854435 117858029 117859106
PVIR120649508 120672124 120673641 120674238 120691907 120707988 120708004
PHAI112875293 112893646 112895064 112895291
PDA103696664 103697123 103717453
EGU105034543 105040273
MUS103983316 103997061
DCT110100600 110100789 110111389 110112357
PEQ110019951 110024265
AOF109829816 109832903
ATR18421580 18443473 18443474
SMOSELMODRAFT_119241(AMP1C-2) SELMODRAFT_134963(AMP1A-2) SELMODRAFT_402884(AMP1D2-1) SELMODRAFT_408011 SELMODRAFT_421595(AMP1A-1) SELMODRAFT_61588(AMP1D3-1) SELMODRAFT_61589(AMP1D1-1) SELMODRAFT_73556(AMP1C-1) SELMODRAFT_81471(AMP1B-1) SELMODRAFT_86742(AMP1D1-2) SELMODRAFT_87649(AMP1D2-2) SELMODRAFT_88219(AMP1B-2)
PPP112276812 112285880
CMECYME_CMT078C
SCEYJR126C(VPS70)
SEUBDI49_3135
SPAOSPAR_J03030
AGOAGOS_AER157C
ERCEcym_1131 Ecym_2370
KLAKLLA0_B04543g KLLA0_C09735g KLLA0_D16588g
KMXKLMA_30460(TRE2) KLMA_40518(VPS70) KLMA_50496(VPS70)
LTHKLTH0D18128g KLTH0G12122g
VPOKpol_1023p102 Kpol_1036p74 Kpol_1072p2
ZROZYRO0B14828g ZYRO0F11814g
CGRCAGL0F03575g CAGL0M00616g
NCSNCAS_0B01170(NCAS0B01170) NCAS_0C01180(NCAS0C01180) NCAS_0J02130(NCAS0J02130)
NDINDAI_0J02840(NDAI0J02840) NDAI_0K01190(NDAI0K01190) NDAI_0K01450(NDAI0K01450)
TPFTPHA_0C00760(TPHA0C00760) TPHA_0D01410(TPHA0D01410) TPHA_0K00560(TPHA0K00560)
TBLTBLA_0A04020(TBLA0A04020) TBLA_0B06200(TBLA0B06200) TBLA_0D01260(TBLA0D01260)
TDLTDEL_0D00700(TDEL0D00700)
TGBHG536_0C06100
KAFKAFR_0B03110(KAFR0B03110) KAFR_0E04260(KAFR0E04260)
KNGKNAG_0B06840(KNAG0B06840)
ZMKHG535_0A06360 HG535_0E01610
PPAPAS_FragB_0020 PAS_chr2-1_0825 PAS_chr3_0815
DHADEHA2F05918g DEHA2F13684g
PICPICST_33956(VPS70) PICST_72031(GCP1)
PGUPGUG_00953 PGUG_01372
SPAASPAPADRAFT_144416 SPAPADRAFT_51890
LELLELG_02618 LELG_04284
CALCAALFM_C400070CA(CaO19.374) CAALFM_C700170WA(VPS70)
CTPCTRG_00114
COTCORT_0E02330 CORT_0H00250
CDUCD36_40130 CD36_70380
CTENCANTEDRAFT_108527 CANTEDRAFT_131148
YLIYALI0A20416g YALI0B05258g
CLUCLUG_00264 CLUG_01780 CLUG_05581 CLUG_05583
CLUSA9F13_08g00715 A9F13_25g00154 A9F13_30g00231
CAURCJI97_002119 CJI97_003594
SLBAWJ20_1786(TRE1) AWJ20_4763(VPS70)
PKZC5L36_0A10430 C5L36_0B02930 C5L36_0E02590
BNNFOA43_000164 FOA43_000425 FOA43_002181
BBRXBRETT_000931 BRETT_003036 BRETT_003809
OPAHPODL_00640 HPODL_01427 HPODL_01642
NCRNCU03108
NTENEUTE1DRAFT126170(NEUTE1DRAFT_126170) NEUTE1DRAFT128695(NEUTE1DRAFT_128695)
SMPSMAC_02840
PANPODANSg1583 PODANSg5808 PODANSg7712
TTTTHITE_2113532
MTMMYCTH_2296221 MYCTH_97974
CTHRCTHT_0060400
MGRMGG_01370 MGG_10330 MGG_15288
PPEIPpBr36_00881 PpBr36_05618 PpBr36_09661 PpBr36_11470
TMNUCRPA7_3623
SSCKSPSK_03979
FGRFGSG_00925 FGSG_03114 FGSG_08141
FPUFPSE_02110 FPSE_05463 FPSE_12042
FVRFVEG_00695 FVEG_01656 FVEG_10836
FOXFOXG_00899 FOXG_02825 FOXG_12287
NHENECHADRAFT_30822 NECHADRAFT_72738
TRETRIREDRAFT_64193
TRRM419DRAFT_82006
MAWMAC_07416
MAJMAA_00651
CMTCCM_05496 CCM_07921
PLJVFPFJ_09041
VALVDBG_03787 VDBG_05714
VDAVDAG_01015 VDAG_07650
CFJCFIO01_01015 CFIO01_05000 CFIO01_09339 CFIO01_12790
CHIGCH63R_05974 CH63R_10563
SAPOSAPIO_CDS6122 SAPIO_CDS6521
ELAUCREL1_10332 UCREL1_6365 UCREL1_6954
PFYPFICI_00360 PFICI_06814 PFICI_13673 PFICI_14110 PFICI_14225
SSLSS1G_12100
BFUBCIN_05g07840
MBEMBM_02019 MBM_03473
PSCOLY89DRAFT_605107 LY89DRAFT_709623
GLZGLAREA_05007 GLAREA_08605
ANIAN4018.2
AFMAFUA_1G03740
ACTACLA_030870
NFINFIA_020930
AORAO090003000972 AO090005000053 AO090012000157 AO090023000534
ANGANI_1_512164(An18g03980)
AFVAFLA_000700 AFLA_001868 AFLA_002831 AFLA_006880
ALUCAKAW2_31200A
ACHEACHE_11549A ACHE_60356S
APUUAPUU_40333A
PCSPc16g07930
PDPPDIP_21460
TMFPMAA_055210
TRGTRUGW13939_00576
CIMCIMG_01443 CIMG_04607
CPWCPC735_049960 CPC735_071930
UREUREG_01358 UREG_01813
PBLPAAG_05758
PBNPADG_07630
ABEARB_01296 ARB_02390
TVETRV_00002 TRV_02192
AJEHCAG_04594 HCAG_05749
BGHBDBG_02060 BDBG_04612
PNOSNOG_00541 SNOG_08356 SNOG_15558
PTEPTT_00283 PTT_07770 PTT_15837 PTT_19605
BZECOCCADRAFT_23192 COCCADRAFT_57482 COCCADRAFT_6467 COCCADRAFT_88509 COCCADRAFT_9633
BSCCOCSADRAFT_151036 COCSADRAFT_170206 COCSADRAFT_181258 COCSADRAFT_90417
BORCOCMIDRAFT_25775 COCMIDRAFT_87995 COCMIDRAFT_96373 COCMIDRAFT_98877
AALTCC77DRAFT_1016735 CC77DRAFT_1022736 CC77DRAFT_1069392 CC77DRAFT_1094060 CC77DRAFT_308235
ZTRMYCGRDRAFT_65087 MYCGRDRAFT_95621
PFJMYCFIDRAFT_215389 MYCFIDRAFT_51270
FFUCLAFUR5_04238 CLAFUR5_09465
BCOMBAUCODRAFT_30252
NPAUCRNP2_9074 UCRNP2_9553
TMLGSTUM_00011706001
CNECNA02920
CNBCNBA2810
CNGCNAG_00309
CGICGB_B3400W
TMSTREMEDRAFT_29057
TASAA1Q1_05886
TVSTRAVEDRAFT_115468 TRAVEDRAFT_63345 TRAVEDRAFT_69990
DSQDICSQDRAFT_169462 DICSQDRAFT_183749
PCOPHACADRAFT_136862 PHACADRAFT_249741 PHACADRAFT_257507
SHSSTEHIDRAFT_166121 STEHIDRAFT_166122 STEHIDRAFT_167860
HIRHETIRDRAFT_170646
PSQPUNSTDRAFT_112379 PUNSTDRAFT_142528
FMEFOMMEDRAFT_125440 FOMMEDRAFT_141695
GTRGLOTRDRAFT_70286 GLOTRDRAFT_98267
LBCLACBIDRAFT_245820
MPRMPER_11864 MPER_12788
MRRMoror_12536 Moror_15307 Moror_4736
MOREE1B28_006035 E1B28_010976 E1B28_012661
CCICC1G_00193
SCMSCHCODRAFT_255134
ABPAGABI1DRAFT106593(AGABI1DRAFT_106593) AGABI1DRAFT72743(AGABI1DRAFT_72743)
ABVAGABI2DRAFT146446(AGABI2DRAFT_146446) AGABI2DRAFT219485(AGABI2DRAFT_219485)
PCUBJR316_0004886 JR316_0004887
CPUTCONPUDRAFT_103296 CONPUDRAFT_89530
SLASERLADRAFT_360310 SERLADRAFT_461557
UMAUMAG_02217
PFPPFL1_04880
MGLMGL_4102
MRTMRET_3725
MSYMMSY001_1187
MLRMELLADRAFT_88704
ACANACA1_108270
FCYFRACYDRAFT_240831
PIFPITG_00273 PITG_00289 PITG_12818 PITG_12824
PSOJPHYSODRAFT_263158 PHYSODRAFT_351795 PHYSODRAFT_505788 PHYSODRAFT_511364 PHYSODRAFT_513922 PHYSODRAFT_561807 PHYSODRAFT_561809
SPARSPRG_00397
EHXEMIHUDRAFT_443039
GTTGUITHDRAFT_159725
XACXAC3611
XCIXCAW_04314
XCTJ151_03797
XCJJ158_03773
XCUJ159_03769
XCNJ169_03794
XCWJ162_03774
XCRJ163_03769
XCMJ164_03770
XCFJ172_03787
XFUXFF4834R_chr35050
XAOXAC29_18390
XHRXJ27_12145
XGABI317_04015
XARXB05_12885
XHYFZ025_05655
XEUXSP_003440
XHDLMG31886_37010
XBCELE36_03315
RHDR2APBS1_2448
RTHLRK53_12905
DJICH75_13475
DJAHY57_16725
DTLH8F01_02795
LRZBJI69_14735
LPYFIV34_07350
WOCBA177_02740
NIYFQ775_07950
NGLRG1141_PA06890 RG1141_PA09800
NGGRG540_PA06740 RG540_PA08630
MOCBB934_32525
MIVC4E04_14725
CMBCSW64_13525
DAAAKL17_1621
NTND5366_08625
SVCSTVA_11980
BFDNCTC4823_00618
NMKCHR53_04330
BCHSJNE38_08745
KYRCVV65_06025
LACYA4V08_23485
CBOLCGC65_04620
CADCuri_c05180
LPILLIP_2160
SACGFDZ84_37015
SVISvir_18700
SESPBN6_52180
GLJGKIL_2068
STISthe_2347 Sthe_2595 Sthe_2748
DDRDeide_1p01240
DPDDeipe_4056
DEINDAAJ005_04755
FGIOP10G_3000
PLHVT85_04685
SACISinac_6856
PBORBSF38_01517
AGVOJF2_26260
BHCJFL75_20740
ABAAcid345_2466 Acid345_2819 Acid345_2823
ACAACP_0923
ACMAciX9_1255
GMAAciX8_1890
GRWFTO74_15000
TSAAciPR4_1765
TRSTerro_1701
TALBFTW19_12465
ABASACPOL_3614 ACPOL_6695
EDAGWR55_01360
SUSAcid_4582
PFERIRI77_35750
CTMCabther_A1283
CVLJ8C06_05345
CHLOJ8C02_06225
ABACLuPra_00453
GAUGAU_0163
GBAJ421_1389 J421_4758
RBCBN938_0794
RMRRmar_2092
RMGRhom172_0780
RBARAWN76_014145
CPICpin_4009
CHIHGWR21_03430
FGGFSB75_08780
ARACE0W69_006330
FLNFLA_5821
PGINFRZ67_03280
SHGSph21_2671
MUPA0256_23570
MUCMuYL_0306
MGKFSB76_03320
MGIKGO620_016425
OLIFKG96_10760
CMRCycma_4791
CAMUCA2015_4599
BBDBelba_2615
ALMAO498_10040
SLISlin_0518
SRDSD10_06045
SMONAWR27_00220
SPIRCWM47_12125
SPIKEXU85_23625
SPIBG8759_26200
DFEDfer_1367
RSIRunsl_1076
RUNDR864_14445
RUPDTQ70_19910
EOLEmtol_3082
HYGAUC43_04755
HYPA0257_12695
HYZAXW84_20830
HNVDDQ68_15175
CHKD4L85_26555
RBIRB2501_12577 RB2501_14204
MARTBTR34_02900
MARBCJ263_14795
MRSMurru_3206
MUTGVT53_05405
MAQILDL77_18255
PTQP700755_000290
SYISB49_06915
MUREQY75_03830
HAHHalar_2490 Halar_3520
 » show all
Reference
1  [PMID:9123729]
  Authors
Heston WD.
  Title
Characterization and glutamyl preferring carboxypeptidase function of prostate specific membrane antigen: a novel folate hydrolase.
  Journal
Urology 49:104-12 (1997)
DOI:10.1016/S0090-4295(97)00177-5
Reference
2  [PMID:9187245]
  Authors
Rawlings ND, Barrett AJ.
  Title
Structure of membrane glutamate carboxypeptidase.
  Journal
Biochim Biophys Acta 1339:247-52 (1997)
DOI:10.1016/S0167-4838(97)00008-3
  Sequence
[hsa:2346]
Reference
3  [PMID:9685395]
  Authors
Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT
  Title
Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.
  Journal
J Biol Chem 273:20417-24 (1998)
DOI:10.1074/jbc.273.32.20417
  Sequence
[ssc:397677]
Reference
4  [PMID:9501243]
  Authors
Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT.
  Title
Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II.
  Journal
Proc Natl Acad Sci U S A 95:3215-20 (1998)
DOI:10.1073/pnas.95.6.3215
  Sequence
[rno:85309]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.21
IUBMB Enzyme Nomenclature: 3.4.17.21
ExPASy - ENZYME nomenclature database: 3.4.17.21
BRENDA, the Enzyme Database: 3.4.17.21
CAS: 9074-87-7

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