KEGG   ENZYME: 3.4.17.3Help
Entry
EC 3.4.17.3                 Enzyme                                 

Name
lysine carboxypeptidase;
carboxypeptidase N;
arginine carboxypeptidase;
kininase I;
anaphylatoxin inactivator;
plasma carboxypeptidase B;
creatine kinase conversion factor;
bradykinase;
kininase Ia;
hippuryllysine hydrolase;
bradykinin-decomposing enzyme;
protaminase;
CPase N;
creatinine kinase convertase;
peptidyl-L-lysine(-L-arginine) hydrolase;
CPN
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal basic amino acid, preferentially lysine
Comment
A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989
Orthology
K01292  carboxypeptidase N catalytic subunit
Genes
HSA: 1369(CPN1)
PTR: 107966811(CPN1)
PPS: 100994885(CPN1)
GGO: 101136315(CPN1)
PON: 100448102(CPN1)
NLE: 100595544(CPN1)
MCC: 709434(CPN1)
MCF: 102146119(CPN1)
CSAB: 103216379 103216380
RRO: 104656557(CPN1)
RBB: 108535064(CPN1)
CJC: 100412406(CPN1)
SBQ: 101050699(CPN1)
MMU: 93721(Cpn1)
RNO: 365466(Cpn1)
CGE: 100752048(Cpn1)
NGI: 103731905 103733166(Cpn1)
HGL: 101718051(Cpn1)
CCAN: 109681489(Cpn1)
OCU: 100344758(CPN1)
TUP: 102499941(CPN1)
CFA: 477795(CPN1)
AML: 100467677(CPN1)
UMR: 103676448(CPN1)
ORO: 101363324(CPN1)
FCA: 101090390(CPN1)
PTG: 102973010(CPN1)
AJU: 106966861(CPN1)
BTA: 536753(CPN1)
BOM: 102283003(CPN1)
PHD: 102336544(CPN1)
CHX: 102180453(CPN1)
OAS: 101120287(CPN1)
SSC: 100157984(CPN1)
CFR: 102505284(CPN1)
CDK: 105084312(CPN1)
BACU: 103018234(CPN1)
LVE: 103083659(CPN1)
OOR: 101280134(CPN1)
ECB: 100070412(CPN1)
EPZ: 103542363(CPN1)
EAI: 106846702(CPN1)
MYB: 102262371(CPN1)
MYD: 102761933(CPN1)
HAI: 109379588(CPN1)
RSS: 109443938(CPN1)
PALE: 102894046(CPN1)
LAV: 100664930(CPN1)
TMU: 101340515
MDO: 100020383(CPN1)
SHR: 100924516(CPN1)
GGA: 769143(CPN1)
MGP: 100545641(CPN1)
CJO: 107316068(CPN1)
APLA: 101803617(CPN1)
ACYG: 106033451(CPN1)
TGU: 100231475(CPN1)
GFR: 102043170(CPN1)
FAB: 101818188(CPN1)
PHI: 102110254(CPN1)
PMAJ: 107206689(CPN1)
CCW: 104697908(CPN1)
FPG: 101919893(CPN1)
FCH: 102053681(CPN1)
CLV: 102095577(CPN1)
EGZ: 104129072(CPN1)
AAM: 106494714(CPN1)
ASN: 102373779(CPN1)
AMJ: 102567467(CPN1)
PSS: 102453241(CPN1)
CMY: 102944605(CPN1)
CPIC: 101948942(CPN1)
ACS: 100563397(cpn1)
PVT: 110084028(CPN1)
PBI: 103054238(CPN1)
GJA: 107121131(CPN1)
XLA: 108696975 398791(cpn1.S)
XTR: 550020(cpn1)
NPR: 108789679(CPN1)
DRE: 337172(cpn1)
SGH: 107566747 107581572(cpn1)
IPU: 108274305(cpn1)
AMEX: 103037340(cpn1)
TRU: 101063492(cpn1)
LCO: 104927896(cpn1)
NCC: 104953335(cpn1)
MZE: 101471524(cpn1)
OLA: 101156125(cpn1)
XMA: 102227125(cpn1)
PRET: 103481278(cpn1)
NFU: 107387875(cpn1)
CSEM: 103381454(cpn1)
LCF: 108898746(cpn1)
HCQ: 109523878(cpn1)
BPEC: 110154274(cpn1)
SASA: 100196707(cpn1)
ELS: 105026237(cpn1)
SFM: 108940406(cpn1)
LCM: 102367336(CPN1)
CMK: 103186570(cpn1)
 » show all
Taxonomy
Reference
1  [PMID:7341915]
  Authors
Plummer TH Jr, Erdos EG.
  Title
Human plasma carboxypeptidase N.
  Journal
Methods Enzymol 80 Pt C:442-9 (1981)
Reference
2  [PMID:6750606]
  Authors
Levin Y, Skidgel RA, Erdos EG.
  Title
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i).
  Journal
Proc Natl Acad Sci U S A 79:4618-22 (1982)
DOI:10.1073/pnas.79.15.4618
Reference
3  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.3
IUBMB Enzyme Nomenclature: 3.4.17.3
ExPASy - ENZYME nomenclature database: 3.4.17.3
BRENDA, the Enzyme Database: 3.4.17.3
CAS: 9013-89-2

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