KEGG ENZYME: 3.4.17.3

ENZYME: 3.4.17.3

Entry

EC 3.4.17.3                 Enzyme

Name

lysine carboxypeptidase;
carboxypeptidase N;
arginine carboxypeptidase;
kininase I;
anaphylatoxin inactivator;
plasma carboxypeptidase B;
creatine kinase conversion factor;
bradykinase;
kininase Ia;
hippuryllysine hydrolase;
bradykinin-decomposing enzyme;
protaminase;
CPase N;
creatinine kinase convertase;
peptidyl-L-lysine(-L-arginine) hydrolase;
CPN

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Release of a C-terminal basic amino acid, preferentially lysine

Comment

A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).

History

EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989

Orthology

K01292

carboxypeptidase N catalytic subunit

Genes

HSA:	1369(CPN1)

PTR:	107966811(CPN1)

PPS:	100994885(CPN1)

GGO:	101136315(CPN1)

PON:	100448102(CPN1)

PPYG:

129006789(CPN1)

NLE:	100595544(CPN1)

HMH:	116478644(CPN1)

SSYN:

129467622(CPN1)

MCC:	709434(CPN1)

MCF:	102146119(CPN1)

MTHB:

126963393

MNI:	105478495(CPN1)

CSAB:

103216380

CATY:

105581828(CPN1)

PANU:

100997838(CPN1)

TGE:	112631730(CPN1)

MLEU:

105537743(CPN1)

RRO:	104656557(CPN1)

RBB:	108535064(CPN1)

TFN:	117068618(CPN1)

PTEH:

111538692(CPN1)

CANG:

105507151(CPN1)

CJC:	100412406(CPN1)

SBQ:	101050699(CPN1)

CIMI:

108306275(CPN1)

ANAN:

105708285(CPN1)

CSYR:

103263188(CPN1)

MMUR:

105873449(CPN1)

LCAT:

123650141(CPN1)

PCOQ:

105824346(CPN1)

OGA:	100950512(CPN1)

MMU:	93721(Cpn1)

MCAL:

110285505(Cpn1)

MPAH:

110330628(Cpn1)

RNO:	365466(Cpn1)

MCOC:

116103884(Cpn1)

ANU:	117714194(Cpn1)

MUN:	110552974(Cpn1)

CGE:	100752048(Cpn1)

MAUA:

101837904(Cpn1)

PROB:

127233400(Cpn1)

PLEU:

114706457(Cpn1)

MORG:

121454343(Cpn1)

MFOT:

126504693

AAMP:

119809079(Cpn1)

NGI:

103731905

HGL:	101718051(Cpn1)

CPOC:

100725809(Cpn1)

CCAN:

109681489(Cpn1)

DORD:

105986679(Cpn1)

DSP:	122115859(Cpn1)

PLOP:

125346170(Cpn1)

NCAR:

124985110

MMMA:

107149792(Cpn1)

OCU:

100344758

TUP:	102499941(CPN1)

GVR:	103588795(CPN1)

CFA:	477795(CPN1)

CLUD:

112672187(CPN1)

VVP:	112914786(CPN1)

VLG:	121484114(CPN1)

NPO:	129493865(CPN1)

AML:	100467677(CPN1)

UMR:	103676448(CPN1)

UAH:	113251825(CPN1)

UAR:	123795859(CPN1)

ELK:

111145084

LLV:

125085202

MPUF:

101681991(CPN1)

MNP:	132016694(CPN1)

MLK:	131828554(CPN1)

NVS:	122899284(CPN1)

ORO:	101363324(CPN1)

EJU:	114205443(CPN1)

ZCA:	113923926(CPN1)

MLX:	118024860(CPN1)

NSU:	110589353(CPN1)

LWW:	102728246(CPN1)

FCA:	101090390(CPN1)

PYU:	121037103(CPN1)

PCOO:

112854684(CPN1)

PBG:	122493131(CPN1)

PVIV:

125147799(CPN1)

LRUF:

124506716

PTG:	102973010(CPN1)

PPAD:

109272764(CPN1)

PUC:

125932876

AJU:

106966861

HHV:	120243179(CPN1)

BTA:	536753(CPN1)

BOM:	102283003(CPN1)

BBUB:

102398093(CPN1)

BBIS:

105002723(CPN1)

CHX:	102180453(CPN1)

OAS:	101120287(CPN1)

BTAX:

128067968(CPN1)

CSUM:

138070254(CPN1)

ODA:	120873526(CPN1)

CCAD:

122446057(CPN1)

MREE:

136158278(CPN1)

MBEZ:

129555965(CPN1)

SSC:	100157984(CPN1)

CFR:	102505284(CPN1)

CBAI:

105081749(CPN1)

CDK:	105084312(CPN1)

VPC:	102535178(CPN1)

BACU:

103018234(CPN1)

BMUS:

118882928(CPN1)

LVE:	103083659(CPN1)

OOR:	101280134(CPN1)

DLE:	111172400(CPN1)

PCAD:

102983536(CPN1)

PSIU:

116741651(CPN1)

NASI:

112393013(CPN1)

ECB:	100070412(CPN1)

EPZ:	103542363(CPN1)

EAI:	106846702(CPN1)

MYB:	102262371(CPN1)

MYD:	102761933(CPN1)

MMYO:

118669863(CPN1)

MLF:	102424554(CPN1)

MDT:	132214226(CPN1)

PKL:	118719387(CPN1)

EFUS:

103288470(CPN1)

MNA:	107542522(CPN1)

DRO:	112300350(CPN1)

SHON:

118999526(CPN1)

AJM:	119064550(CPN1)

PDIC:

114497546(CPN1)

PHAS:

123828910(CPN1)

MMF:	118632434(CPN1)

PPAM:

129077284(CPN1)

HAI:	109379588(CPN1)

RFQ:	117035766(CPN1)

PALE:

102894046(CPN1)

PGIG:

120609211(CPN1)

PVP:	105304666(CPN1)

RAY:	107499779(CPN1)

MJV:	108409592(CPN1)

TOD:	119233594(CPN1)

SARA:

101538658(CPN1)

SETR:

125994867(CPN1)

LAV:	100664930(CPN1)

TMU:

101340515

ETF:	101650835(CPN1)

DNM:	101432402(CPN1)

MDO:	100020383(CPN1)

GAS:	123238256(CPN1)

SHR:	100924516(CPN1)

AFZ:

127551782

PCW:	110215500(CPN1)

TVP:	118830142(CPN1)

PBRV:

138145563(CPN1)

OAA:	100087406(CPN1)

GGA:	769143(CPN1)

PCOC:

116231739(CPN1)

MGP:	100545641(CPN1)

CJO:	107316068(CPN1)

TPAI:

128078032(CPN1)

LMUT:

125693320(CPN1)

NMEL:

110399891(CPN1)

APLA:

101803617(CPN1)

ACYG:

106033451(CPN1)

CATA:

118245196(CPN1)

AFUL:

116491494(CPN1)

TGU:	100231475(CPN1)

LSR:	110473605(CPN1)

SCAN:

103813898(CPN1)

PMOA:

120502201(CPN1)

OTC:	121341719(CPN1)

PRUF:

121350359(CPN1)

GFR:	102043170(CPN1)

FAB:	101818188(CPN1)

OMA:	130254981(CPN1)

PHI:	102110254(CPN1)

PMAJ:

107206689(CPN1)

CCAE:

111930929(CPN1)

CCW:	104697908(CPN1)

CBRC:

103624529(CPN1)

ETL:	114071122(CPN1)

ZAB:	102065024(CPN1)

ZLE:	135449607(CPN1)

ACHL:

103808932(CPN1)

SVG:	106858994(CPN1)

MMEA:

130582283(CPN1)

HRT:	120755755(CPN1)

SATI:

136364136(CPN1)

FPG:	101919893(CPN1)

FCH:	102053681(CPN1)

CCRI:

104161967(CPN1)

NNT:	104400444(CPN1)

SHAB:

115608702(CPN1)

ACUN:

113481538(CPN1)

TALA:

104357431(CPN1)

ACHC:

115348470(CPN1)

HALD:

104322467(CPN1)

HLE:	104830148(CPN1)

AGEN:

126043220

GCL:

127017924

CSTI:

104561412

LDI:	104340587(CPN1)

MNB:	103777043(CPN1)

DPUB:

104307067(CPN1)

PPUS:

135176473(CPN1)

AVIT:

104273245(CPN1)

BRHI:

104493026(CPN1)

EGZ:	104129072(CPN1)

NNI:	104012843(CPN1)

PCRI:

104024885(CPN1)

PCAO:

104041609(CPN1)

PADL:

103916348(CPN1)

AFOR:

103897680(CPN1)

FGA:	104076696(CPN1)

GSTE:

104263987(CPN1)

CLV:	102095577(CPN1)

MUI:	104546281(CPN1)

PGUU:

104465332(CPN1)

PLET:

104620630(CPN1)

EHS:	104516536(CPN1)

CMAC:

104473885(CPN1)

CUCA:

104063161(CPN1)

TEO:	104372632(CPN1)

BREG:

104638005(CPN1)

OHA:	104338201(CPN1)

ACAR:

104523769

CPEA:

104390920(CPN1)

CVF:	104282386(CPN1)

RTD:	128911919(CPN1)

AAM:	106494714(CPN1)

AROW:

112964190(CPN1)

NPD:	112957193(CPN1)

DNE:	112989784(CPN1)

SCAM:

104145962(CPN1)

ASN:	102373779(CPN1)

AMJ:	102567467(CPN1)

PSS:	102453241(CPN1)

CMY:	102944605(CPN1)

CCAY:

125640271(CPN1)

DCC:	119858202(CPN1)

CPIC:

101948942(CPN1)

TST:	117880168(CPN1)

CABI:

116817684(CPN1)

MRV:	120369441(CPN1)

ACS:	100563397(cpn1)

ASAO:

132770833(CPN1)

PVT:	110084028(CPN1)

SUND:

121925729(CPN1)

PBI:	103054238(CPN1)

PMUR:

107287742(CPN1)

CTIG:

120314190(CPN1)

TSR:	106537857(CPN1)

PGUT:

117678571(CPN1)

APRI:

131200783(CPN1)

PTEX:

113436613(CPN1)

NSS:	113419461(CPN1)

VKO:	123026486(CPN1)

PMUA:

114597618(CPN1)

PRAF:

128414375(CPN1)

ZVI:	118094020(CPN1)

HCG:	128350917(CPN1)

GJA:	107121131(CPN1)

STOW:

125438023(CPN1)

EMC:	129332332(CPN1)

XLA:	108696975(cpn1.L) 398791(cpn1.S)

XTR:	550020(cpn1)

NPR:	108789679(CPN1)

RTEM:

120946767(CPN1)

BBUF:

121003335(CPN1)

BGAR:

122941567(CPN1)

MUO:	115470053(CPN1)

GSH:	117359933(CPN1)

DRE:	337172(cpn1)

SRX:	107722209 107755523

SANH:

107684044 107702463

SGH:	107566747 107581572(cpn1)

CCAR:

109094710 109100080(cpn1)

CAUA:

113069504 113073777 113111602

CGIB:

127969430 128025382

PTET:

122355688(cpn1)

LROH:

127174456(cpn1)

OMC:	131550597(cpn1)

PPRM:

120474619(cpn1)

RKG:	130102807(cpn1)

MAMB:

125255437(cpn1)

CIDE:

127523531

CERY:

137008114(cpn1)

MASI:

127423381 127426890

TROS:

130569087(cpn1)

TDW:	130439129(cpn1)

MANU:

129421153(cpn1)

IPU:

108274305

IFU:	128617148(cpn1)

PHYP:

113527392(cpn1)

SMEO:

124389254(cpn1)

TFD:	113639001(cpn1)

TVC:	132837955(cpn1)

TRN:	134321337(cpn1)

AMEX:

103037340(cpn1)

CMAO:

118809402(cpn1)

EEE:	113587528(cpn1)

CHAR:

105888912(cpn1)

TRU:	101063492(cpn1)

TFS:	130522987(cpn1)

LCO:	104927896(cpn1)

NCC:	104953335(cpn1)

TBEN:

117473968(cpn1)

CGOB:

115024261(cpn1)

PGEO:

117464810(cpn1)

GACU:

117544912(cpn1)

EMAC:

134871054(cpn1)

ELY:	117247647(cpn1)

EFO:	125880433(cpn1)

PLEP:

121959210(cpn1)

SLUC:

116061352(cpn1)

ECRA:

117936820(cpn1)

ESP:	116670730(cpn1)

PFLV:

114548707(cpn1)

GAT:	120818892(cpn1)

PPUG:

119213106(cpn1)

AFB:	129091149(cpn1)

CLUM:

117748695(cpn1)

PSWI:

130203861(cpn1)

CANA:

137789421(cpn1)

MSAM:

119916412(cpn1)

SCHU:

122867201(cpn1)

CUD:	121528292(cpn1)

ALAT:

119009416(cpn1)

ASTR:

137588321(cpn1)

MZE:	101471524(cpn1)

ONL:	100709588(cpn1)

OAU:	116329798(cpn1)

OLA:	101156125(cpn1)

OML:	112154450(cpn1)

CSAI:

133419683(cpn1)

XMA:	102227125(cpn1)

XCO:	114151892(cpn1)

XHE:	116726731(cpn1)

PRET:

103481278(cpn1)

PFOR:

103153384(cpn1)

PLAI:

106948317(cpn1)

PMEI:

106907600(cpn1)

GAF:	122823006(cpn1)

PPRL:

129368166(cpn1)

CVG:	107094718(cpn1)

CTUL:

119792205

GMU:	124875638(cpn1)

NFU:	107387875(cpn1)

KMR:	108248818(cpn1)

ALIM:

106536196(cpn1)

NWH:	119423498 119429703

AOCE:

111567296(cpn1)

EJA:	138201936(cpn1)

MCEP:

125022728(cpn1)

CSEM:

103381454(cpn1)

POV:	109627019(cpn1)

SSEN:

122759021(cpn1)

HHIP:

117752373(cpn1)

HSP:	118100721(cpn1)

PPLT:

128426353(cpn1)

SMAU:

118287039(cpn1)

LCF:

108898746

SDU:	111220291(cpn1)

SLAL:

111657127(cpn1)

XGL:	120794083(cpn1)

HCQ:	109523878(cpn1)

SSCV:

125991791(cpn1)

SBIA:

133495649(cpn1)

PEE:	133417756(cpn1)

PTAO:

133469418(cpn1)

BPEC:

110154274(cpn1)

MALB:

109963082(cpn1)

BSPL:

114846334(cpn1)

SJO:	128380870(cpn1)

SASA:

100196707(cpn1)

STRU:

115162743(cpn1)

OTW:	121840653(cpn1)

OMY:	110491814(cpn1)

OGO:	124020313(cpn1)

ONE:	115106756(cpn1)

OKI:	109865570(cpn1)

OKE:	118363536(cpn1)

SALP:

111977708

SNH:	120046428(cpn1)

CCLU:

121572070(cpn1)

ELS:	105026237(cpn1)

SFM:	108940406(cpn1)

PKI:	111836044(cpn1)

AANG:

118221373(cpn1)

LOC:	102688364(cpn1)

PSPA:

121322021 121325968

ARUT:

117415124 117417952

PSEX:

120543182(cpn1)

LCM:	102367336(CPN1)

RTP:	109924839(cpn1)

CPLA:

122561289(cpn1)

HOC:	132826344(cpn1)

LERI:

129704140(cpn1)

PMRN:

116941424

LRJ:	133345431 133345438

BFO:	118414428 118419334

BBEL:

109466903 109478523 109484003

LPIC:

129277818

ARUN:

117303185

AFRA:

136037325

EAF:

111712708

VDE:

111248153

VJA:

111272575

SMM:	Smp_142190

» show all

Reference

1 [PMID:7341915]

Authors

Plummer TH Jr, Erdos EG.

Title

Human plasma carboxypeptidase N.

Journal

Methods Enzymol 80 Pt C:442-9 (1981)
DOI:10.1016/s0076-6879(81)80038-9

Reference

2 [PMID:6750606]

Authors

Levin Y, Skidgel RA, Erdos EG.

Title

Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i).

Journal

Proc Natl Acad Sci U S A 79:4618-22 (1982)
DOI:10.1073/pnas.79.15.4618

Reference

3 [PMID:3074547]

Authors

Skidgel RA.

Title

Basic carboxypeptidases: regulators of peptide hormone activity.

Journal

Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.3

IUBMB Enzyme Nomenclature:

3.4.17.3

ExPASy - ENZYME nomenclature database:

3.4.17.3

BRENDA, the Enzyme Database:

3.4.17.3

CAS:

9013-89-2

DBGET integrated database retrieval system