KEGG   ENZYME: 3.4.19.1Help
Entry
EC 3.4.19.1                 Enzyme                                 

Name
acylaminoacyl-peptidase;
acylamino-acid-releasing enzyme;
N-acylpeptide hydrolase;
N-formylmethionine (fMet) aminopeptidase;
alpha-N-acylpeptide hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide
Comment
Active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. Displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. Inhibited by diisopropyl fluorophosphate. In peptidase family S9 (prolyl oligopeptidase family).
History
EC 3.4.19.1 created 1978 as EC 3.4.14.3, transferred 1981 to EC 3.4.19.1
Orthology
K01303  acylaminoacyl-peptidase
Genes
HSA: 327(APEH)
PTR: 460376(APEH)
PPS: 100985786(APEH)
GGO: 101141597(APEH)
PON: 100435231(APEH)
NLE: 100582434(APEH)
MCC: 705948(APEH)
MCF: 102122091(APEH)
CSAB: 103227638(APEH)
RRO: 104667317(APEH)
RBB: 108526983(APEH)
CJC: 100396609(APEH)
SBQ: 101046863(APEH)
MMU: 235606(Apeh)
RNO: 24206(Apeh)
CGE: 100761732(Apeh)
NGI: 103750179(Apeh)
HGL: 101715825(Apeh)
CCAN: 109692697(Apeh)
OCU: 100354109(APEH)
TUP: 102483690(APEH)
CFA: 476622(APEH)
AML: 100475477(APEH)
UMR: 103674818(APEH)
ORO: 101385988(APEH)
FCA: 101085867(APEH)
PTG: 102959601(APEH)
AJU: 106979244(APEH)
BTA: 514666(APEH)
BOM: 102269347(APEH)
BIU: 109575998(APEH)
PHD: 102339268(APEH)
CHX: 102177845(APEH)
OAS: 101103273(APEH)
SSC: 396961(APEH)
CFR: 102505664(APEH)
CDK: 105087692(APEH)
BACU: 103017766(APEH)
LVE: 103078029(APEH)
OOR: 101276478(APEH)
ECB: 100053100(APEH)
EPZ: 103553415(APEH)
EAI: 106830693(APEH)
MYB: 102261178(APEH)
MYD: 102768766(APEH)
HAI: 109376042(APEH)
RSS: 109440308 109443456(APEH)
PALE: 102893074(APEH)
LAV: 100675656(APEH)
TMU: 101358967
MDO: 100027962(APEH)
SHR: 100934071(APEH)
OAA: 100091478(APEH)
GGA: 415926(APEH) 770794(AAREL)
MGP: 100548252(APEH) 104913124
CJO: 107319598 107319599(APEH)
ACYG: 106048758(APEH)
GFR: 102042072(APEH) 102042238
FAB: 101810254 101815864(APEH)
PMAJ: 107210481
CCW: 104683426
FPG: 101919631(APEH) 101919804
FCH: 102059371(APEH) 102059543
CLV: 102097899(APEH)
EGZ: 104132490
AAM: 106492157
ASN: 102378133(APEH)
AMJ: 102565732(APEH)
PSS: 102451421(APEH)
CMY: 102935556(APEH)
CPIC: 101935673(APEH)
ACS: 100567769(apeh) 103277916
PVT: 110076744(APEH)
PBI: 103058104(APEH) 103063154
GJA: 107109058(APEH) 107109059
XLA: 108714585(apeh.L)
XTR: 100491896(apeh)
NPR: 108803244(APEH)
DRE: 100333019(apeh) 678599(zgc:136971)
SRX: 107730641
SANH: 107698444(apeh)
SGH: 107573312(apeh)
CCAR: 109083451(apeh)
IPU: 108265705(apeh) 108265926
AMEX: 103034957(apeh)
TRU: 101067673(apeh) 101069353
LCO: 104928033(apeh) 104931711
NCC: 104955726(apeh)
PRET: 103467450
NFU: 107373674
KMR: 108235266
CSEM: 103384671
LCF: 108877888(apeh)
SDU: 111218987
HCQ: 109528691
BPEC: 110164529
MALB: 109968751
SASA: 106566520(apeh) 106572275
OTW: 112222360(apeh)
ELS: 105013991
SFM: 108925571
LCM: 102351784(APEH) 102352874
CMK: 103176730(apeh)
CIN: 100176229
APLC: 110984912
AME: 727648
BIM: 100747821
BTER: 100649598
SOC: 105200317
AEC: 105145648
ACEP: 105627926
PBAR: 105428617
HST: 105184645
DQU: 106746095
CFO: 105256026
LHU: 105674837
PGC: 109861327
PCF: 106792095
NVI: 100677815
MDL: 103578939
TCA: 659540
DPA: 109543917
NVL: 108557532
BMOR: 101747101
PMAC: 106718043
PRAP: 111002001
HAW: 110378249
PXY: 105388523
DNX: 107168241
CLEC: 106663725
ZNE: 110830876
FCD: 110855503
TUT: 107362082
CEL: CELE_R11E3.8(dpf-5)
CBR: CBG11649(Cbr-dpf-5)
BMY: Bm1_43100
TSP: Tsp_03275
CRG: 105317255
MYI: 110448837
OBI: 106869032
LAK: 106176014
EGL: EGR_01472
EPA: 110245204
ADF: 107346701
HMG: 100199643
AQU: 100637042
ATH: AT4G14570(AARE)
THJ: 104822254
CPAP: 110825053
CIT: 102610646
TCC: 18603106
GRA: 105800572
GHI: 107929144
DZI: 111306676
EGR: 104456143
CCAJ: 109789595
CAM: 101502347
LJA: Lj0g3v0015409.1(Lj0g3v0015409.1)
PPER: 18791115
ZJU: 107413108
CSV: 101207866
CMO: 103491214
MCHA: 111009690
CMAX: 111499357
CMOS: 111460152
CPEP: 111806948
RCU: 8280187
JCU: 105632075
POP: 7473443
JRE: 108989467
VVI: 100242540
SLY: 101258623
SPEN: 107015056
SOT: 102595350
CANN: 107868464
INI: 109175906
SIND: 105171627
OEU: 111393713
HAN: 110894440
LSV: 111910042
CCAV: 112501670
DCR: 108199676
BVG: 104903937
SOE: 110792382
NNU: 104589648
DOSA: Os10t0415800-01(Os10g0415800)
ATS: 109763464(LOC109763464)
ZMA: 100281428(cl9977_1) 100285393(pco091746)
PDA: 103711615
EGU: 105053423
MUS: 103969438
DCT: 110114561
PEQ: 110032413
ATR: 18429541
PPP: 112278092
DDI: DDB_G0292456(apeh)
DFA: DFA_09138(apeh)
CPV: cgd5_4370
ILO: IL0039
BRA: BRADO3729
BCE: BC0192
BCL: ABC2617
OIH: OB1081
GKA: GK0961
GTN: GTNG_0849
LDB: Ldb1011
LBR: LVIS_2137
ACE: Acel_2009
TTH: TT_C1241
FNU: FN1128
SRU: SRU_2034
SMR: Smar_0411
HBU: Hbut_0515
PAS: Pars_0732
 » show all
Taxonomy
Reference
1  [PMID:1137989]
  Authors
Tsunasawa S, Narita K, Ogata K.
  Title
Purification and properties of acylamino acid-releasing enzyme from rat liver.
  Journal
J Biochem (Tokyo) 77:89-102 (1975)
Reference
2  [PMID:477668]
  Authors
Unger T, Nagelschmidt M, Struck H.
  Title
N-Acetylaminoacyl-p-nitranilidase from human placenta. Purification and some properties.
  Journal
Eur J Biochem 97:205-11 (1979)
DOI:10.1111/j.1432-1033.1979.tb13104.x
Reference
3  [PMID:3305492]
  Authors
Kobayashi K, Smith JA.
  Title
Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction.
  Journal
J Biol Chem 262:11435-45 (1987)
  Sequence
[rno:24206]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.1
IUBMB Enzyme Nomenclature: 3.4.19.1
ExPASy - ENZYME nomenclature database: 3.4.19.1
BRENDA, the Enzyme Database: 3.4.19.1
CAS: 73562-30-8

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