KEGG   ENZYME: 3.4.19.14Help
Entry
EC 3.4.19.14                Enzyme                                 

Name
leukotriene-C4 hydrolase;
gamma-glutamyl leukotrienase;
GGT5
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
leukotriene C4 + H2O = leukotriene D4 + L-glutamate [RN:R09875]
Reaction(KEGG)
Substrate
leukotriene C4 [CPD:C02166];
H2O [CPD:C00001]
Product
leukotriene D4 [CPD:C05951];
L-glutamate [CPD:C00025]
Comment
The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase) [3-4].
History
EC 3.4.19.14 created 2012
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K18592  gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase
Genes
HSA: 2678(GGT1) 2687(GGT5)
PTR: 458711(GGT5) 470168(GGT1)
PPS: 100967282(GGT5)
GGO: 101125952(GGT1) 101131358 101131705 101135843 101143017 101145096 101149759 101150471 101152175(GGT5) 101152651(GGTLC1) 109023098 109024567 109024570 109025385
PON: 100441042 100441416 100448415(GGT1)
NLE: 100592068(GGT1) 100593662(GGTLC2) 105740088(GGT5)
MCC: 700936(GGT1) 707545(GGT1) 720256 720345(GGT5)
MCF: 101925950 102116394 102127846(GGT1) 102134834
CSAB: 103223055 103223058(GGT1) 103223059(GGT5) 103247573
RRO: 104659185 104660851 104671265 104672519(GGT1) 104672556(GGT5) 104673929 104679570
RBB: 108523107 108524736 108524999(GGTLC2) 108530059(GGT5) 108540615(GGT1)
CJC: 100386116(GGT1) 100386469(GGT5)
SBQ: 101040412(GGT5) 101040942(GGT1)
MMU: 14598(Ggt1) 23887(Ggt5)
RNO: 116568(Ggt1) 29566(Ggt5)
CGE: 100763802(Ggt1) 100764088(Ggt5)
NGI: 103738067(Ggt5) 103738068(Ggt1)
HGL: 101704114 101722156(Ggt1) 101723554(Ggt5)
CCAN: 109690511(Ggt1) 109690512(Ggt5)
OCU: 100340452(GGT1) 100358051(GGT5)
TUP: 102484803(GGT5) 102485218(GGT1)
CFA: 486400(GGT1) 486401(GGT5)
AML: 100477159(GGT5) 100477414(GGT1)
UMR: 103669205(GGT1) 103669206(GGT5)
ORO: 101379030(GGT5) 101379513(GGT1)
FCA: 101081761(GGT1) 101082015(GGT5)
PTG: 102958863(GGT1) 102959431(GGT5)
AJU: 106979664(GGT1) 106979678(GGT5)
BTA: 615582(GGT1) 787326(GGT5)
BOM: 102274785(GGT5) 102275636(GGT1)
BIU: 109571421(GGT5) 109571454(GGT1)
PHD: 102334457(GGT5)
CHX: 102182719(GGT5) 102182996(GGT1)
OAS: 101112423(GGT5) 105603000(GGT1)
SSC: 100157523(GGT5) 397095(GGT1)
CFR: 102519279(GGT5) 102519525(GGT1)
CDK: 105095196(GGT1) 105095198(GGT5)
BACU: 102998230(GGT5) 103005716(GGT1)
LVE: 103074197(GGT5) 103074850(GGT1)
OOR: 101276857(GGT5) 101277450(GGT1)
ECB: 100050188(GGT1) 100050259(GGT5)
EPZ: 103561723(GGT1) 103561729(GGT5)
EAI: 106847124(GGT5) 106847125(GGT1)
MYB: 102249132(GGT5) 102249421(GGT1)
MYD: 102760265 102760559(GGT5)
HAI: 109394901(GGT5) 109394902(GGT1)
PALE: 102884483(GGT5) 102885072(GGT1)
LAV: 100659754(GGT5) 100661760(GGT1)
MDO: 100011908(GGT5) 100022333
SHR: 100926551 100929990(GGT5)
GGA: 416943(GGT5) 416945(GGT1)
MGP: 100539371(GGT5) 100546423(GGT1)
CJO: 107321394(GGT1) 107321395(GGT5)
APLA: 101799004(GGT5) 101799199(GGT1)
ACYG: 106031306(GGT5) 106031309(GGT1)
TGU: 100219009(GGT1) 100228598(GGT5)
GFR: 102039892(GGT5) 102040061(GGT1)
FAB: 101809556(GGT5) 101809751(GGT1)
PHI: 102101463(GGT1) 102101655(GGT5)
PMAJ: 107211682(GGT1) 107211684(GGT5)
CCW: 104688577(GGT1) 104688578(GGT5)
FPG: 101910629(GGT1) 101910798(GGT5)
FCH: 102051506(GGT5) 102051670(GGT1)
CLV: 102093198(GGT5) 102093381(GGT1)
EGZ: 104130094(GGT1) 104130095(GGT5)
AAM: 106486250(GGT1) 106486335(GGT5)
ASN: 102380809(GGT1) 102381220(GGT5)
AMJ: 102559791(GGT5) 102560017(GGT1)
PSS: 102446859 102460884(GGT1)
CMY: 102943869 102944084(GGT1)
CPIC: 101940263(GGT5) 101940612(GGT1)
ACS: 100554005(ggt1) 100555377(ggt5)
PVT: 110081928(GGT1) 110081999(GGT5)
PBI: 103052856(GGT5) 103053083(GGT1)
GJA: 107115096(GGT1) 107115098(GGT5)
XLA: 108707119(ggt5.S) 108716030(ggt5.L) 444291(ggt1.S) 734898(ggt1.L)
XTR: 100497518(ggt5) 448376(ggt1)
DRE: 100333757(ggt5b) 393387(ggt1a) 566746(ggt1l2.2) 569014(ggt1b) 569734(ggt5a)
OLA: 100820714(ggt1a) 100820715(ggt1b) 100820716(ggtl1a) 100820728(ggtl1b) 101161114 105357674
LCM: 102346851(GGT5) 102347571
CIN: 100182976
DME: Dmel_CG1492(CG1492) Dmel_CG17636(CG17636) Dmel_CG4829(CG4829) Dmel_CG6461(Ggt-1)
DSI: Dsimw501_GD15947(Dsim_GD15947) Dsimw501_GD16490(Dsim_GD16490) Dsimw501_GD17313(Dsim_GD17313) Dsimw501_GD24475(Dsim_GD24475)
TUT: 107369183
CEL: CELE_C53D5.5(C53D5.5) CELE_H14N18.4(H14N18.4) CELE_T03D8.6(T03D8.6)
BMY: Bm1_25455
TSP: Tsp_01479
EGL: EGR_00079
ATH: AT1G69820(GGT3) AT4G29210(GGT4) AT4G39640(GGT1) AT4G39650(GGT2)
LJA: Lj0g3v0143209.1(Lj0g3v0143209.1) Lj0g3v0143209.2(Lj0g3v0143209.2) Lj2g3v0894400.1(Lj2g3v0894400.1)
RCU: 8265116
JCU: 105637810
VVI: 100247429
BVG: 104902346
SOE: 110779252
OSA: 4324525
DOSA: Os01t0151400-01(Os01g0151400) Os04t0457500-01(Os04g0457500)
ATS: 109776875(LOC109776875) 109778729(LOC109778729)
PPP: 112282076
CRE: CHLREDRAFT_170508(GTP1)
SPO: SPAC56E4.06c(ggt2) SPAC664.09(ggt1)
CNE: CND01560
CNB: CNBD4760
ABP: AGABI1DRAFT71574(AGABI1DRAFT_71574)
ABV: AGABI2DRAFT239353(GGT1)
FCY: FRACYDRAFT_229350(GGT_1)
 » show all
Taxonomy
Reference
1  [PMID:9139674]
  Authors
Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW
  Title
Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice.
  Journal
J Biol Chem 272:12305-10 (1997)
DOI:10.1074/jbc.272.19.12305
Reference
2  [PMID:11463821]
  Authors
Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW
  Title
Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.
  Journal
Mol Cell Biol 21:5389-95 (2001)
DOI:10.1128/MCB.21.16.5389-5395.2001
  Sequence
[mmu:23887]
Reference
3  [PMID:12163373]
  Authors
Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW
  Title
Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
  Journal
Am J Pathol 161:481-90 (2002)
DOI:10.1016/S0002-9440(10)64204-6
  Sequence
[mmu:23887]
Reference
4  [PMID:21447318]
  Authors
Wickham S, West MB, Cook PF, Hanigan MH
  Title
Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase  enzymes.
  Journal
Anal Biochem 414:208-14 (2011)
DOI:10.1016/j.ab.2011.03.026
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.14
IUBMB Enzyme Nomenclature: 3.4.19.14
ExPASy - ENZYME nomenclature database: 3.4.19.14
BRENDA, the Enzyme Database: 3.4.19.14

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