KEGG   ENZYME: 3.4.19.6Help
Entry
EC 3.4.19.6                 Enzyme                                 

Name
pyroglutamyl-peptidase II;
thyroliberinase;
pyroglutamyl aminopeptidase II;
, thyrotropin-releasing factor pyroglutamate aminopeptidase;
pyroglutamate aminopeptidase II;
pyroglutamyl peptidase II;
thyroliberin-hydrolyzing pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading peptidase;
TRH aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of the N-terminal pyroglutamyl group from pGlu!His-Xaa tripeptides and pGlu!His-Xaa-Gly tetrapeptides
Comment
Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.19.6 created 1992
Orthology
K01306  pyroglutamyl-peptidase II
Genes
HSA: 29953(TRHDE)
PTR: 467071(TRHDE)
PPS: 100977009(TRHDE)
GGO: 101146939(TRHDE)
PON: 100460431(TRHDE)
NLE: 100588911(TRHDE)
MCC: 717653(TRHDE)
MCF: 102125346(TRHDE)
CSAB: 103238733(TRHDE)
RRO: 104654596(TRHDE)
RBB: 108528755(TRHDE)
CJC: 100415258(TRHDE)
SBQ: 101052029(TRHDE)
MMU: 237553(Trhde)
RNO: 366894(Trhde)
CGE: 100762211(Trhde)
NGI: 103735329(Trhde)
HGL: 101714026(Trhde)
CCAN: 109699927(Trhde)
OCU: 100352490(TRHDE)
TUP: 102488055(TRHDE)
CFA: 481166(TRHDE)
AML: 100471917(TRHDE)
UMR: 103656979(TRHDE)
ORO: 101370339(TRHDE)
FCA: 101085556(TRHDE)
PTG: 102949202(TRHDE)
BTA: 100336818(TRHDE)
BOM: 102279861(TRHDE)
BIU: 109558307
PHD: 102327954(TRHDE)
CHX: 102175003(TRHDE)
OAS: 100310794(TRHDE)
SSC: 100620702(TRHDE)
CFR: 102512405(TRHDE)
CDK: 105095993(TRHDE)
BACU: 103006364(TRHDE)
LVE: 103087695(TRHDE)
OOR: 101271464(TRHDE)
ECB: 100057250(TRHDE)
EPZ: 103560318(TRHDE) 103564918
EAI: 106822089(TRHDE)
MYB: 102257792(TRHDE)
MYD: 102759450(TRHDE)
HAI: 109387696(TRHDE)
RSS: 109456586(TRHDE)
PALE: 102892053(TRHDE)
LAV: 100670199(TRHDE)
TMU: 101357589
MDO: 100016797(TRHDE)
OAA: 100079276(TRHDE)
GGA: 427868(TRHDE)
MGP: 100550266(TRHDE)
CJO: 107310276(TRHDE)
APLA: 101793030(TRHDE)
ACYG: 106046722(TRHDE)
TGU: 100230387(TRHDE)
GFR: 102039975(TRHDE)
FAB: 101811314(TRHDE)
PHI: 102104144(TRHDE)
PMAJ: 107204601(TRHDE)
CCW: 104698393(TRHDE)
FPG: 101921757(TRHDE)
FCH: 102050378(TRHDE)
CLV: 102089579(TRHDE)
EGZ: 104132924(TRHDE)
AAM: 106488685(TRHDE)
ASN: 102377345(TRHDE)
AMJ: 102572757(TRHDE)
PSS: 102455963(TRHDE)
CMY: 102929819(TRHDE)
CPIC: 101933457(TRHDE)
ACS: 100551808(trhde)
PVT: 110085004(TRHDE)
PBI: 103057029(TRHDE)
GJA: 107115337(TRHDE)
XLA: 108705027(trhde.L) 108713143(trhde.S)
XTR: 100489066(trhde)
NPR: 108788310(TRHDE) 108800741
DRE: 562409(trhde.2)
AMEX: 103029429(trhde)
TRU: 101065693(trhde)
LCO: 104931506(trhde) 109141150
MZE: 101477232(trhde)
OLA: 101170139(trhde)
XMA: 102225911(trhde)
PRET: 103459315(trhde)
NFU: 107386826(trhde)
CSEM: 103382523(trhde)
LCF: 108895871(trhde)
HCQ: 109532578
BPEC: 110161508(trhde)
ELS: 105023119(trhde)
SFM: 108936360(trhde) 108942250
LCM: 102350514 102356972(TRHDE)
CMK: 103185331(trhde)
SKO: 100372228
LHU: 105673248
 » show all
Taxonomy
Reference
1  [PMID:115687]
  Authors
Bauer K, Nowak P.
  Title
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
  Journal
Eur J Biochem 99:239-46 (1979)
DOI:10.1111/j.1432-1033.1979.tb13250.x
Reference
2  [PMID:2862039]
  Authors
O'Connor B, O'Cuinn G.
  Title
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain.
  Journal
Eur J Biochem 150:47-52 (1985)
DOI:10.1111/j.1432-1033.1985.tb08986.x
Reference
3  [PMID:20504468]
  Authors
Wilk S, Wilk EK
  Title
Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme.
  Journal
Neurochem Int 15:81-9 (1989)
DOI:10.1016/0197-0186(89)90079-X
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.6
IUBMB Enzyme Nomenclature: 3.4.19.6
ExPASy - ENZYME nomenclature database: 3.4.19.6
BRENDA, the Enzyme Database: 3.4.19.6
CAS: 60063-88-9

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