KEGG   ENZYME: 3.4.21.109Help
Entry
EC 3.4.21.109               Enzyme                                 

Name
matriptase;
serine protease 14;
membrane-type serine protease 1;
MT-SP1;
prostamin;
serine protease TADG-15;
tumor-associated differentially-expressed gene 15 protein;
ST14;
breast cancer 80 kDa protease;
epithin;
serine endopeptidase SNC19
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment
This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Belongs in peptidase family S1A.
History
EC 3.4.21.109 created 2006
Orthology
K08670  suppressor of tumorigenicity protein 14
Genes
HSA: 6768(ST14)
PTR: 100188950(ST14)
PPS: 100969412(ST14)
GGO: 101128044(ST14)
PON: 100448596(ST14)
NLE: 100583520(ST14)
MCC: 718848(ST14)
MCF: 102117178(ST14)
CSAB: 103248837(ST14)
RRO: 104656766(ST14)
RBB: 108529077(ST14)
CJC: 100411816(ST14)
SBQ: 101030484(ST14)
MMU: 19143(St14)
RNO: 114093(St14)
CGE: 100755225(St14)
NGI: 103749253(St14)
HGL: 101697952(St14)
CCAN: 109688547(St14)
OCU: 100101609(ST14)
TUP: 102486454(ST14)
CFA: 489278(ST14)
AML: 100466959(ST14)
UMR: 103660745(ST14)
ORO: 101372817(ST14)
FCA: 101095767(ST14)
PTG: 102953519(ST14)
AJU: 106970577(ST14)
BTA: 767617(ST14)
BOM: 102277353(ST14)
BIU: 109554629(ST14)
PHD: 102328545(ST14)
CHX: 102187300(ST14)
OAS: 101119684(ST14)
SSC: 100517843(ST14)
CFR: 102503998(ST14)
CDK: 105094280(ST14)
BACU: 102997802(ST14)
LVE: 103071841(ST14)
OOR: 101274463(ST14)
ECB: 100072676(ST14)
EAI: 106842158(ST14)
MYB: 102241616(ST14)
MYD: 102771965(ST14)
HAI: 109392376(ST14)
RSS: 109435854(ST14)
PALE: 102887302(ST14)
LAV: 100654624(ST14)
TMU: 101354762
MDO: 100021603(ST14)
SHR: 100930600(ST14)
OAA: 100075025(ST14)
GGA: 419731(ST14)
MGP: 100547194(ST14)
CJO: 107324168(ST14)
APLA: 101797476(ST14)
ACYG: 106040585(ST14)
TGU: 100223474(ST14)
GFR: 102045487(ST14)
FAB: 101807159(ST14)
PHI: 102099462(ST14)
PMAJ: 107214462(ST14)
CCAE: 111939399(ST14)
CCW: 104692158(ST14)
FPG: 101919145(ST14)
FCH: 102052997(ST14)
CLV: 102084734(ST14)
EGZ: 104129611(ST14)
AAM: 106491009(ST14)
ASN: 102369849(ST14) 102385059
AMJ: 102566264(ST14) 102571438
PSS: 102451977(ST14) 102460566
CMY: 102929499(ST14) 102933252
CPIC: 101933655(ST14) 101936040
ACS: 100559139(st14)
PVT: 110078111(ST14)
PBI: 103048713(ST14)
XLA: 394363(st14.L) 494753(st14.S)
XTR: 448647(st14)
NPR: 108800339(ST14)
DRE: 678603(st14a)
LCM: 102354865 102356973(ST14)
SPU: 584950
LAK: 106160037
 » show all
Taxonomy
Reference
1  [PMID:10962009]
  Authors
Lee SL, Dickson RB, Lin CY.
  Title
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.
  Journal
J Biol Chem 275:36720-5 (2000)
DOI:10.1074/jbc.M007802200
Reference
2  [PMID:10373424]
  Authors
Lin CY, Anders J, Johnson M, Sang QA, Dickson RB.
  Title
Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.
  Journal
J Biol Chem 274:18231-6 (1999)
DOI:10.1074/jbc.274.26.18231
  Sequence
[hsa:6768]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.109
IUBMB Enzyme Nomenclature: 3.4.21.109
ExPASy - ENZYME nomenclature database: 3.4.21.109
BRENDA, the Enzyme Database: 3.4.21.109
CAS: 241475-96-7

DBGET integrated database retrieval system