KEGG   ENZYME: 3.4.21.110Help
Entry
EC 3.4.21.110               Enzyme                                 

Name
C5a peptidase;
streptococcal C5a peptidase;
ScpA;
ScpB;
SCPA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The primary cleavage site is at His67!Lys68 in human C5a with a minor secondary cleavage site at Ala58!Ser59
Comment
This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate specificity. Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties [1,4]. Belongs in peptidase family S8A.
History
EC 3.4.21.110 created 2006
Orthology
K08652  C5a peptidase
Genes
SPY: SPy_2010(scpA)
SPZ: M5005_Spy1715(scpA)
SPYM: M1GAS476_1768(scpA)
SPYA: A20_1761c(scpA)
SPM: spyM18_2074(scpA)
SPG: SpyM3_1726(scpA)
SPS: SPs1724
SPH: MGAS10270_Spy1782(scpA)
SPI: MGAS10750_Spy1807(scpA)
SPJ: MGAS2096_Spy1744(scpA)
SPK: MGAS9429_Spy1720(scpA)
SPF: SpyM51681(scpA)
SPB: M28_Spy1700(scpA)
STG: MGAS15252_1558(scpA)
STX: MGAS1882_1619(scpA)
SOZ: Spy49_1669c(scpA)
SPYH: L897_08565
SAG: SAG0416
SAK: SAK_1320(scpB)
SAGI: MSA_4990
SAGR: SAIL_5100
SAGP: V193_02285
SAGC: DN94_02285
SAGN: W903_0519(scpA)
SEZ: Sez_0946(scpZ)
SEQ: SZO_10150
SEZO: SeseC_01242(vpr)
SEQU: Q426_04435
SUB: SUB1154(scpA)
SDS: SDEG_0933(scpB)
SDA: GGS_0906(scpB)
SDC: SDSE_0972(scpA)
SIK: K710_0995
 » show all
Taxonomy
Reference
1  [PMID:3906656]
  Authors
Wexler DE, Chenoweth DE, Cleary PP.
  Title
Mechanism of action of the group A streptococcal C5a inactivator.
  Journal
Proc Natl Acad Sci U S A 82:8144-8 (1985)
DOI:10.1073/pnas.82.23.8144
Reference
2  [PMID:1996961]
  Authors
Bohnsack JF, Mollison KW, Buko AM, Ashworth JC, Hill HR.
  Title
Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.
  Journal
Biochem J 273 ( Pt 3):635-40 (1991)
Reference
3  [PMID:1452354]
  Authors
Cleary PP, Prahbu U, Dale JB, Wexler DE, Handley J.
  Title
Streptococcal C5a peptidase is a highly specific endopeptidase.
  Journal
Infect Immun 60:5219-23 (1992)
Reference
4  [PMID:12354115]
  Authors
Anderson ET, Wetherell MG, Winter LA, Olmsted SB, Cleary PP, Matsuka YV.
  Title
Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes.
  Journal
Eur J Biochem 269:4839-51 (2002)
DOI:10.1046/j.1432-1033.2002.03183.x
Reference
5  [PMID:10809707]
  Authors
Stafslien DK, Cleary PP.
  Title
Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate.
  Journal
J Bacteriol 182:3254-8 (2000)
DOI:10.1128/JB.182.11.3254-3258.2000
Reference
6  [PMID:16565520]
  Authors
Terao Y, Yamaguchi M, Hamada S, Kawabata S.
  Title
Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils.
  Journal
J Biol Chem 281:14215-23 (2006)
DOI:10.1074/jbc.M513408200
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.110
IUBMB Enzyme Nomenclature: 3.4.21.110
ExPASy - ENZYME nomenclature database: 3.4.21.110
BRENDA, the Enzyme Database: 3.4.21.110
CAS: 100179-39-3

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