KEGG   ENZYME: 3.4.21.117Help
Entry
EC 3.4.21.117               Enzyme                                 

Name
stratum corneum chymotryptic enzyme;
kallikrein 7;
SCCE;
KLK7;
PRSS6;
hK7
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of proteins with aromatic side chains in the P1 position
Comment
This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6!Cya7, Tyr16!Leu17, Phe25!Tyr26 and Tyr26!Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.
History
EC 3.4.21.117 created 2006
Orthology
K08668  kallikrein 7
Genes
HSA: 5650(KLK7)
PTR: 468973(KLK7)
PPS: 100970185(KLK8)
GGO: 101148068(KLK7)
PON: 100173841(KLK7)
MCC: 722683(KLK7)
MCF: 102134711(KLK7)
CSAB: 103235545(KLK7)
RRO: 104667248(KLK7)
RBB: 108532427(KLK7)
CJC: 103790022(KLK7)
SBQ: 101047010(KLK7)
MMU: 23993(Klk7)
RNO: 292852(Klk7)
CGE: 100753553(Klk7)
NGI: 103743766(Klk7)
HGL: 101705516(Klk7)
CCAN: 109683887(Klk7)
OCU: 100343784(KLK7)
TUP: 102467699(KLK7)
CFA: 611780(KLK7)
AML: 100476432(KLK7)
UMR: 103657286(KLK7)
ORO: 101382840(KLK7)
FCA: 101088894(KLK7)
PTG: 102964470(KLK7)
AJU: 106989674(KLK7)
BTA: 506380(KLK7)
BOM: 102282184(KLK7)
BIU: 109571922(KLK7)
PHD: 102315895(KLK7)
CHX: 102178562(KLK7)
OAS: 101115562(KLK7)
SSC: 100359349(KLK7)
CDK: 105100155(KLK7)
BACU: 102998157(KLK7)
LVE: 103070574(KLK7)
OOR: 101276423(KLK7)
ECB: 100146194(KLK7)
EPZ: 103567752(KLK7)
EAI: 106847578(KLK7)
HAI: 109391010(KLK7)
PALE: 102897729
LAV: 100666907
TMU: 101345301
MDO: 100012470(KLK7)
CCAR: 109059652
AMEX: 111197071
 » show all
Taxonomy
Reference
1  [PMID:7794273]
  Authors
Skytt A, Stromqvist M, Egelrud T.
  Title
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.
  Journal
Biochem Biophys Res Commun 211:586-9 (1995)
DOI:10.1006/bbrc.1995.1853
  Sequence
[hsa:5650]
Reference
2  [PMID:8393902]
  Authors
Egelrud T.
  Title
Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation.
  Journal
J Invest Dermatol 101:200-4 (1993)
DOI:10.1111/1523-1747.ep12363804
Reference
3  [PMID:8034709]
  Authors
Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T.
  Title
Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.
  Journal
J Biol Chem 269:19420-6 (1994)
  Sequence
[hsa:5650]
Reference
4  [PMID:10974542]
  Authors
Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP.
  Title
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation.
  Journal
Gene 254:119-28 (2000)
DOI:10.1016/S0378-1119(00)00280-8
  Sequence
[hsa:5650]
Reference
5  [PMID:15191543]
  Authors
Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R.
  Title
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
  Journal
J Invest Dermatol 123:62-6 (2004)
DOI:10.1111/j.0022-202X.2004.22708.x
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.117
IUBMB Enzyme Nomenclature: 3.4.21.117
ExPASy - ENZYME nomenclature database: 3.4.21.117
BRENDA, the Enzyme Database: 3.4.21.117
CAS: 155215-90-0

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