KEGG   ENZYME: 3.4.21.118Help
Entry
EC 3.4.21.118               Enzyme                                 

Name
kallikrein 8;
KLK8;
PRSS19;
human kallikrein 8;
hK8;
mK8;
ovasin;
tumor-associated differentially expressed gene 14;
TADG-14;
NP;
neuropsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
Comment
The enzyme is activated by removal of an N-terminal prepropeptide [2,4]. The highest amidolytic activity is observed using Boc-Val-Pro-Arg!7-amido-4-methylcoumarin, which is a substrate of alpha-thrombin [2,4]. Substrates lacking basic amino acids in the P1 position are not cleaved [4]. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen [3] and is associated with diseases such as ovarian cancer and Alzheimer's disease [4]. Belongs in peptidase family S1A.
History
EC 3.4.21.118 created 2006
Orthology
K08650  kallikrein 8
Genes
HSA: 11202(KLK8)
PTR: 456239(KLK8)
GGO: 101151682(KLK8)
PON: 100437370(KLK8)
NLE: 100587419(KLK8)
MCC: 719488(KLK8)
MCF: 102143235(KLK8)
CSAB: 103235109(KLK8)
RRO: 104667249(KLK8)
RBB: 108532406(KLK8)
CJC: 100404633(KLK8)
SBQ: 101047321(KLK8)
MMU: 259277(Klk8)
RNO: 308565(Klk8)
CGE: 100752953(Klk8)
NGI: 103743767(Klk8)
HGL: 101715440(Klk8)
CCAN: 109683871(Klk8)
OCU: 100344291(KLK8)
TUP: 102468122
CFA: 484352(KLK8)
AML: 100476177(KLK8)
UMR: 103657288(KLK8)
ORO: 101383132
FCA: 101090308(KLK8)
PTG: 102964756(KLK8)
AJU: 106989678(KLK8)
BTA: 618438(KLK8)
BOM: 102281911(KLK8)
BIU: 109571931(KLK8)
PHD: 102316246(KLK8)
CHX: 102178849(KLK8)
OAS: 101112755(KLK8)
SSC: 110261027(KLK8)
CFR: 102521031(KLK8)
CDK: 105100154(KLK8)
ECB: 100067301(KLK8)
EPZ: 103567751(KLK8)
EAI: 106847546(KLK8)
MYB: 102241466(KLK8)
MYD: 102764579(KLK8)
HAI: 109391034(KLK8)
RSS: 109439361(KLK8)
PALE: 102893463
LAV: 100659511
TMU: 101340570
SHR: 100933656(KLK8)
CJO: 107307352
NCC: 104941648
XMA: 102230174
PRET: 103464362
LCF: 108889075
OTW: 112249655
 » show all
Taxonomy
Reference
1  [PMID:7623137]
  Authors
Chen ZL, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H, et al.
  Title
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.
  Journal
J Neurosci 15:5088-97 (1995)
  Sequence
[mmu:259277]
Reference
2  [PMID:9556608]
  Authors
Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, Shiosaka T, Midorikawa R, Kamachi T, Kawabe A, Shiosaka S.
  Title
Characterization of recombinant and brain neuropsin, a plasticity-related serine protease.
  Journal
J Biol Chem 273:11189-96 (1998)
DOI:10.1074/jbc.273.18.11189
  Sequence
[mmu:259277]
Reference
3  [PMID:16337200]
  Authors
Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T.
  Title
Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.
  Journal
FEBS Lett 579:6879-84 (2005)
DOI:10.1016/j.febslet.2005.11.039
  Sequence
[hsa:11202]
Reference
4  [PMID:16800733]
  Authors
Kishi T, Cloutier SM, Kundig C, Deperthes D, Diamandis EP.
  Title
Activation and enzymatic characterization of recombinant human kallikrein 8.
  Journal
Biol Chem 387:723-31 (2006)
DOI:10.1515/BC.2006.091
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.118
IUBMB Enzyme Nomenclature: 3.4.21.118
ExPASy - ENZYME nomenclature database: 3.4.21.118
BRENDA, the Enzyme Database: 3.4.21.118
CAS: 171715-15-4

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