| Entry |
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| Name |
kallikrein 13;
KLK13;
kallikrein mK13;
mGK-13;
mK13;
mKLK13;
prorenin converting enzyme 1;
PRECE-1;
prorenin-converting enzyme;
PRECE;
proteinase P
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin
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| Comment |
The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.
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| History |
EC 3.4.21.119 created 2006
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| Orthology |
| K09462 | glandular kallikrein 13 |
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| Genes |
» show all
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| Reference |
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| Authors |
Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K. |
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| Title |
Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis. |
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| Journal |
J Biol Chem 265:21027-31 (1990) |
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| Reference |
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| Authors |
Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K. |
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| Title |
A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization. |
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| Journal |
J Biol Chem 265:5930-3 (1990) |
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| Reference |
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| Authors |
Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K. |
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| Title |
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22). |
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| Journal |
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| Reference |
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| Authors |
Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K. |
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| Title |
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. |
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| Journal |
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| Sequence |
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| Other DBs |
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