Entry
Name
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Leu!, Tyr!, Phe!, Met!, Trp!, Gln!, Asn!
Comment
Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family)
History
EC 3.4.21.2 created 1972
Orthology
Genes
MTHB : 126959451 126959986
CATY : 105587355 105593653(CTRC) 105593656
PANU : 101008888 101027045 116271818
TVP : 118836420 118836421 118838733
LMUT : 125703491 125703494
PMOA : 120498997 120499435
PRUF : 121351341 121351382 121351397
ATRC : 139600665 139600783 139600836
GFR : 102039202 102039374 102039552
ACOE : 138121363 138121410
ZAB : 102065082 102067097 102073038
ZLE : 135456632 135456634 135456635 135456637 135456786
SATI : 136370780 136370782
CCIC : 134052886 134052887
ASN : 102384487 102386144 102386393 102386635
AMJ : 102574442 102574676 102575846
CPOO : 109314379 109314516 109314543
GGN : 109293559 109293560 109293788 109293791
ZVI : 118079002 118079003 118086814 118087165
RTEM : 120916258 120916260
ACAT : 141110335 141111480
CSEM : 103384948 107989142
AALB : 109409749 109417827 109426733 109426788
CQU : CpipJ_CPIJ002139 CpipJ_CPIJ011616
CBRI : 134828639 134838216
TPRE : 106649500 106649502 106651994 106651995 111693485 111693486 111693565 111694337
OSN : 115224509 115224512 115224554 115224560
ATEN : 116297736 116297737 116305518 116305520 116308478
MCAZ : 138037239 138051106 138054252 138054253
MFOO : 137995278 137995279 137996850 137998086
PDAM : 113674894 113674914 113682978
» show all
Taxonomy
Reference
Authors
Peanasky RJ, Gratecos D, Baratti J, Rovery M.
Title
Mode of activation of N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C.
Journal
Reference
2
Authors
Folk JE.
Title
Chymotrypsin C (porcine pancreas).
Journal
Methods Enzymol 19:109-112 (1970)
Reference
3
Authors
Wilcox PE.
Title
Chymotrypsinogens - chymotrypsins.
Journal
Methods Enzymol 19:64-108 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.2
ExPASy - ENZYME nomenclature database: 3.4.21.2